Selected Publications

Samareh P, Agudelo-Garcia P, Zhang Z, Gilbert M, Mendoza M, Huang H, Wu JE, Baxter AE, Chen Z, Alexander K, Wherry EJ, Good CR, Berger SL: Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion. The Journal of Immunology 214(11): 2987-3002, Aug 2025.

Aznar MA, Good CR, Barber-Rotenberg JS, Agarwal S, Wilson W, Watts A, Zhang Z, Gonzales D, Donahue G, Hwang WT, Rennels AK, Rech AJ, Kuramitsu S, Huang H, Glastad KM, Alexander KA, Plesa G, Dowd E, Brennan A, Siegel DL, Tanyi J, Haas A, Torigian DA, Nadolski G, Gonzalez VE, Hexner EO, Fraietta JA, Jadlowsky JK, Young RM, Berger SL, June CH, O'Hara MH: Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer. Cell Reports Medicine 6(9): 102301, Aug 2025.

Huang H, Baxter AE, Zhang Z, Good CR*, Alexander KA*, Chen Z, Garcia PAA, Samareh P, Collins SM, Glastad KM, Wang L, Donahue G, Manne S, Giles JR, Shi J, Berger SL, Wherry EJ: Deciphering the role of histone modifications in memory and exhausted CD8 T cells. Scientific Reports 15(1): 17359, May 2025.

Xu DC, Sas-Nowosielska H, Donahue G, Huang H, Pourshafie N, Good CR, Berger SL: Histone acetylation in an Alzheimer's disease cell model promotes homeostatic amyloidreducing pathways. Acta Neuropathologica Communications 12(1): 3, Jan 2024.

Agarwal S, Aznar MA, Rech AJ, Good CR, Kuramitsu S, Da T, Gohil M, Chen L, Hong SA, Ravikumar P, Rennels AK, Salas-Mckee J, Kong W, Ruella M, Davis MM, Plesa G, Fraietta JA, Porter DL, Young RM, June CH.: Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells. Immunity 56(10): 2388- 2407, Oct 2023.

Collins SM, Alexander KA, Lundh S, Dimitri AJ, Zhang Z, Good CR, Fraietta JA, Berger SL: TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells. Science Advances(29), Jul 2023.

Rajurkar M, Parikh AR, Solovyov A, You E, Kulkarni AS, Chu C, Xu KH, Jaicks C, Taylor MS, Wu C, Alexander KA, Good CR, Szabolcs A, Gerstberger S, Tran AV, Xu N, Ebright RY, Van Seventer EE, Vo KD, Tai EC, Lu C, Joseph-Chazan J, Raabe MJ, Nieman LT, Desai N, Arora KS, Ligorio M, Thapar V, Cohen L, Garden PM, Senussi Y, Zheng H, Allen JN, Blaszkowsky LS, Clark JW, Goyal L, Wo JY, Ryan DP, Corcoran RB, Deshpande V, Rivera MN, Aryee MJ, Hong TS, Berger SL, Walt DR, Burns KH, Park PJ, Greenbaum BD, Ting DT.: Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer. Cancer Discovery 12(6): 1462-1481, Jun 2022.

Good CR, Aznar MA, Kuramitsu S, Samareh P, Agarwal S, Donahue G, Ishiyama K, Wellhausen N, Rennels AK, Ma Y, Tian L, Guedan S, Alexander KA, Zhang Z, Rommel PC, Singh N, Glastad KM, Richardson MW, Watanabe K, Tanyi JL, O'Hara MH, Ruella M, Lacey SF, Moon EK, Schuster SJ, Albelda SM, Lanier LL, Young RM, Berger SL, June CH: An NK-like CAR T cell transition in CAR T cell dysfunction. Cell 184(25): 081-6100, Dec 2021.

Alexander KA, Coté A, Nguyen SC, Zhang L, Gholamalamdari O, Agudelo-Garcia P, Lin-Shiao E, Tanim KMA, Lim J, Biddle N, Dunagin MC, Good CR, Mendoza MR, Little SC, Belmont A, Joyce EF, Raj A, Berger SL: p53 mediates target gene association with nuclear speckles for amplified RNA expression. Molecular Cell 81(8): 1666-1681, Apr 2021.

Singh N, Lee YG, Shestova O, Ravikumar P, Hayer KE, Hong SJ, Lu XM, Pajarillo R, Agarwal S, Kuramitsu S, Orlando EJ, Mueller KT, Good CR, Berger SL, Shalem O, Weitzman MD, Frey NV, Maude SL, Grupp SA, June CH, Gill S, Ruella M.: Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction. Cancer Discovery 10(4): 552-567, Apr 2020.