Selected Publications

Anurag Verma*, Jennifer E Huffman*, Alex Rodriguez*, Mitchell Conery*, Molei Liu*, Yuk-Lam Ho, Youngdae Kim, David A Heise, Lindsay Guare, Vidul Ayakulangara Panickan, Helene Garcon, Franciel Linares, Lauren Costa, Ian Goethert, Ryan Tipton, Jacqueline Honerlaw, Laura Davies, Stacey Whitbourne, Jeremy Cohen, Daniel C Posner, Rahul Sangar, Michael Murray, Xuan Wang, Daniel R Dochtermann, Poornima Devineni, Yunling Shi, Tarak Nath Nandi, Themistocles L Assimes, Charles A Brunette, Robert J Carroll, Royce Clifford, Scott Duvall, Joel Gelernter, Adriana Hung, Sudha K Iyengar, Jacob Joseph, Rachel Kember, Henry Kranzler, Colleen M Kripke, Daniel Levey, Shiuh-Wen Luoh, Victoria C Merritt, Cassie Overstreet, Joseph D Deak, Struan FA Grant, Renato Polimanti, Panos Roussos, Gabrielle Shakt, Yan V Sun, Noah Tsao, Sanan Venkatesh, Georgios Voloudakis, Amy Justice, Edmon Begoli, Rachel Ramoni, Georgia Tourassi, Saiju Pyarajan, Philip Tsao, Christopher J O'Donnell, Sumitra Muralidhar, Jennifer Moser, Juan P Casas, Alexander G Bick, Wei Zhou, Tianxi Cai+, Benjamin F Voight+, Kelly Cho+, J Michael Gaziano+, Ravi K Madduri+, Scott Damrauer*+, Katherine P Liao+: Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Science. https://www.science.org/doi/10.1126/science.adj1182, 385: eadj1182, Jul 2024.

Verma, Anurag, Minnier, Jessica, Huffman, Jennifer E, Wan, Emily S, Gao, Lina, Joseph, Jacob, Ho, Yuk-Lam, Wu, Wen-Chih, Cho, Kelly, Gorman, Bryan R, Rajeevan, Nallakkandi, Pyarajan, Saiju, Garcon, Helene, Meigs, James B, Sun, Yan V, Reaven, Peter D, McGeary, John E, Suzuki, Ayako, Gelernter, Joel, Lynch, Julie A, Petersen, Jeffrey M, Zekavat, Seyedeh Maryam, Natarajan, Pradeep, Madison, Cecelia J, Dalal, Sharvari, Jhala, Darshana N, Arjomandi, Mehrdad, Gatsby, Elise, Lynch, Kristine E, Bonomo, Robert A, Freiberg, Mat, Pathak, Gita A, Zhou, Jin J, Donskey, Curtis J, Madduri, Ravi K, Wells, Quinn S, Huang, Rose DL, Polimanti, Renato, Chang, Kyong-Mi, Liao, Katherine P, Tsao, Philip S, Wilson, Peter W.F., Hung, Adriana, O’Donnell, Christopher J, Gaziano, John M, Hauger, Richard L, Iyengar, Sudha K., Luoh, Shiuh-Wen, Million Veteran Program COVID-19 Science Initiative: A MUC5B Gene Polymorphism, rs35705950-T Confers Protective Effects Against COVID-19 Hospitalization but not Severe Disease or Mortality. Am J Respir Crit Care Med. Jun 2022 Notes: Online ahead of print.

Verma A, Damrauer SM, Naseer N, Weaver J, Kripke CM, Guare L, Sirugo G, Kember RL, Drivas TG, Dudek SM, Bradford Y, Lucas A, Judy R, Verma SS, Meagher E, Nathanson KL, Feldman M, Ritchie MD, Rader DJ, For The Penn Medicine BioBank. : The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population. Journal of Precision Medicine Nov 2022.

Verma A, Huffman JE, Gao L, Minnier J, Wu WC, Cho K, Ho YL, Gorman BR, Pyarajan S, Rajeevan N, Garcon H, Joseph J, McGeary JE, Suzuki A, Reaven PD, Wan ES, Lynch JA, Petersen JM, Meigs JB, Freiberg MS, Gatsby E, Lynch KE, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Bonomo RA, Thompson TK, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Gelernter J, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Sun YV, Wilson PWF, O'Donnell CJ, Hung AM, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW; VA Million Veteran Program COVID-19 Science Initiative.: Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait. JAMA Intern Med 182(8): 796-804, Aug 2022.

Huffman JE, Butler-Laporte G, Khan A, Pairo-Castineira E, Drivas TG, Peloso GM, Nakanishi T, Ganna A, Verma A, Baillie JK, Kiryluk K, Richards JB, Zeberg H.: Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19. Nat Genet. 54(2): 125-127, Feb 2022.

Verma, A.*, Tsao, N. L.*, Thomann, L., Ho, Y. L., Iyengar, S. K., Luoh, S. W., Carr, R., Crawford, D., Efird, J. T., Huffman, J., Hung, A., Ivey, K. L., Levin, M., Lynch, J., Natarajan, P., Pyarajan, S., Bick, A., Costa, L., Genovese, G., Hauger, R., Madduri, R., Pathak, G. A., Polimanti, R., Voight, B., Vujkovic, M., Zekavat, M., Zhao, H., Ritchie, M. D., Chang, K. M., Cho, K., Casas, J. P., Tsao, P. S., Gaziano, J. M., O'Donnell, C., Damrauer, S. M., Liao, K. P.: A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. PLoS Genet. 18(4): :e1010113, Apr 2022.

Zhang C, Verma A, Feng Y, Melo MCR, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel MA, Campbell MC, Beggs W, Hirbo J, Wata Mpoloka S, George Mokone G; Regeneron Genetic Center, Nyambo T, Wolde Meskel D, Belay G, Fokunang C, Njamnshi AK, Omar SA, Williams SM, Rader DJ, Ritchie MD, de la Fuente-Nunez C, Sirugo G, Tishkoff SA.: Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection. Proc Natl Acad Sci USA 119(21): e2123000119, May 2022.

Wang L, Desai H, Verma SS, Le A, Hausler R, Verma A, Judy R, Doucette A, Gabriel PE, Nathanson KL, Damrauer SM, Mowery DL, Ritchie MD, Kember RL, Maxwell KN: Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank. Genet Med. 24(3): 601-609, Mar 2021 Notes: doi: 10.1016/j.gim.2021.10.015.

Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB, Marcketta A, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Sun D, Baltzell A, Kury FSP, Backman JD, Girshick AR, O'Dushlaine C, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Li AH, Zhang M, Mbatchou J, Watanabe K, Gurski L, McCarthy SE, Kang HM, Dobbyn L, Stahl E, Verma A, Sirugo G; Regeneron Genetics Center, Ritchie MD, Jones M, Balasubramanian S, Siminovitch K, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Locke AE, Marchini J, Overton JD, Carey DJ, Habegger L, Cantor MN, Rand KA, Hong EL, Reid JG, Ball CA, Baras A, Abecasis GR, Ferreira MAR: Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease. Nat Genet. 54(4): 382-392, Apr 2022.

Anderson, E. M.*, Goodwin, E. C.*, Verma, A.*, Arevalo, C. P., Bolton, M. J., Weirick, M. E., Gouma, S., McAllister, C. M., Christensen, S. R., Weaver, J., Hicks, P., Manzoni, T. B., Oniyide, O., Ramage, H., Mathew, D., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., D'Andrea, K., Kuthuru, O., Dougherty, J., Pattekar, A., Kim, J., Han, N., Apostolidis, S. A., Huang, A. C., Vella, L. A., Kuri-Cervantes, L., Pampena, M. B., Betts, M. R., Wherry, E. J., Meyer, N. J., Cherry, S., Bates, P., Rader, D. J., Hensley, S. E.: Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection. Cell 184(7): 1858-1864.e10, Apr 2021.

Verma, A., Lucas, A., Verma, S. S., Zhang, Y., Josyula, N., Khan, A., Hartzel, D. N., Lavage, D. R., Leader, J., Ritchie, M. D., Pendergrass, S. A.: PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger. Am J Hum Genet 102(4): 592-608, Apr 2018.

Kember, R. L., Merikangas, A. K., Verma, S. S., Verma, A., Judy, R., Damrauer, S. M., Ritchie, M. D., Rader, D. J., Bućan, M.: Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals. Biol Psychiatry 89(3): 236-245, Apr 2021.

Liu, X.*, Verma, A.*, Garcia, G., Jr., Ramage, H., Lucas, A., Myers, R. L., Michaelson, J. J., Coryell, W., Kumar, A., Charney, A. W., Kazanietz, M. G., Rader, D. J., Ritchie, M. D., Berrettini, W. H., Schultz, D. C., Cherry, S., Damoiseaux, R., Arumugaswami, V., Klein, P. S.: Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Proc Natl Acad Sci U S A 118(42), 2021.

Veturi, Y., Lucas, A., Bradford, Y., Hui, D., Dudek, S., Theusch, E., Verma, A., Miller, J. E., Kullo, I., Hakonarson, H., Sleiman, P., Schaid, D., Stein, C. M., Edwards, D. R. V., Feng, Q., Wei, W. Q., Medina, M. W., Krauss, R. M., Hoffmann, T. J., Risch, N., Voight, B. F., Rader, D. J., Ritchie, M. D.: A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts. Nat Genet 53(7): 972-981, Jul 2021.