Aladdin A Riad, PhD
Department: Radiology
Contact information
3620 Hamilton Walk
John Morgan Building Room 174
Philadelphia, PA 19104
John Morgan Building Room 174
Philadelphia, PA 19104
Office: 4073530905
Publications
Education:
BS (Microbiology and Molecular Biology)
University of Central Florida, 2011.
MS (Biomedical Sciences)
University of Central Florida, 2013.
PhD (Biomedical Sciences)
University of Central Florida, 2018.
Permanent linkBS (Microbiology and Molecular Biology)
University of Central Florida, 2011.
MS (Biomedical Sciences)
University of Central Florida, 2013.
PhD (Biomedical Sciences)
University of Central Florida, 2018.
Description of Research Expertise
Research Interests. My Research is focused on development of Sigma 2 Receptor/TMEM97 PET imaging probes, characterizing the function of the Sigma 2 Receptor/TMEM97 through functional cell assays to identify its role in lipid uptake such as LDL and ApoE, and the role that it plays in breast cancer and neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease.Keywords: Sigma 2 Receptor, TMEM97, alpha synuclein, breast cancer, neurodegeneration, Alzheimer's disease, Parkinson's disease, lipids, PET radio tracer development
Selected Publications
Hsieh, C. J., Riad, A., Lee, J. Y., Sahlholm, K., Xu, K., Luedtke, R. R., Mach, R. H.: Interaction of Ligands for PET with the Dopamine D3 Receptor: In Silico and In Vitro Methods. Biomolecules 11(4), 2021.Xie, X. Y., Li, Y. Y., Ma, W. H., Chen, A. F., Sun, Y. T., Lee, J. Y., Riad, A., Xu, D. H., Mach, R. H., Huang, Y. S.: Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σ(2)R/TMEM97 ligands. Eur J Med Chem 209: 112906, 2021.
Izzo, N. J., Colom-Cadena, M., Riad, A. A., Xu, J., Singh, M., Abate, C., Cahill, M. A., Spires-Jones, T. L., Bowen, W. D., Mach, R. H., Catalano, S. M.: Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease. eNeuro 7(6), 2020.
Zeng, C., Riad, A., Mach, R. H.: The Biological Function of Sigma-2 Receptor/TMEM97 and Its Utility in PET Imaging Studies in Cancer. Cancers (Basel) 12(7), 2020.
Riad, A., Lengyel-Zhand, Z., Zeng, C., Weng, C. C., Lee, V. M., Trojanowski, J. Q., Mach, R. H.: The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates. Mol Neurobiol 57(9): 3803-3813, 2020.
Riad, A., Gitto, S. B., Lee, H., Winters, H. D., Martorano, P. M., Hsieh, C. J., Xu, K., Omran, D. K., Powell, D. J., Jr., Mach, R. H., Makvandi, M.: PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response. Molecules 25(24), 2020.
Lee, H., Riad, A., Martorano, P., Mansfield, A., Samanta, M., Batra, V., Mach, R. H., Maris, J. M., Pryma, D. A., Makvandi, M.: PARP-1-Targeted Auger Emitters Display High-LET Cytotoxic Properties In Vitro but Show Limited Therapeutic Utility in Solid Tumor Models of Human Neuroblastoma. J Nucl Med 61(6): 850-856, 2020.
Reilly, S. W., Puentes, L. N., Schmitz, A., Hsieh, C. J., Weng, C. C., Hou, C., Li, S., Kuo, Y. M., Padakanti, P., Lee, H., Riad, A. A., Makvandi, M., Mach, R. H.: Synthesis and evaluation of an AZD2461 [(18)F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant. Bioorg Chem 83: 242-249, 2019.
Zeng, C., Weng, C. C., Schneider, M. E., Jr., Puentes, L., Riad, A., Xu, K., Makvandi, M., Jin, L., Hawkins, W. G., Mach, R. H.: TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death. Cell Death Discov 5: 58, 2019.
Reilly, S. W., Riad, A. A., Hsieh, C. J., Sahlholm, K., Jacome, D. A., Griffin, S., Taylor, M., Weng, C. C., Xu, K., Kirschner, N., Luedtke, R. R., Parry, C., Malhotra, S., Karanicolas, J., Mach, R. H.: Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D(3) Receptor (D(3)R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs). J Med Chem 62(10): 5132-5147, 2019.