Benedicte Lefebvre, MD
Assistant Professor of Clinical Medicine (Cardiovascular Medicine)
Adult Scientific Assistant Director, Cardiovascular Phenotyping Unit, Center for Human Phenomic Science, University of Pennsylvania, Perelman School of Medicine
Fellowship Director, Thalheimer Center for Cardio-Oncology, University of Pennsylvania, Perelman School of Medicine
Department: Medicine
Contact information
11-134 South Pavilion
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
Education:
Pre-Univ (Health Sciences)
Collège Laflèche, Canada, 2007.
Pre-Med (Preparatory Medicine)
McGill University, Canada, 2008.
MD (Doctor of Medicine)
McGill University, Canada, 2012.
Permanent linkPre-Univ (Health Sciences)
Collège Laflèche, Canada, 2007.
Pre-Med (Preparatory Medicine)
McGill University, Canada, 2008.
MD (Doctor of Medicine)
McGill University, Canada, 2012.
Selected Publications
Abhinav Kandala, Amar Rai, Rahul Penumaka, Nicholas S. Wilcox, Benedicte Lefebvre, Michael G. Fradley: Radiomics for the Detection and Prediction of Cardiotoxicity in Patients with Cancer: A Structured Narrative Review. Journal of the American College of Cardiology March 2026 Notes: Abstract accepted at the American College of Cardiology Scientific Session, 2026, New Orleans, LA, USA.Jeffrey L Saver, David M Kent, Scott E Kasner, Benjamin Koethe, John D Carroll, Gilles Chatellier, Anthony J Furlan, Howard C Herrmann, Peter Jüni, Jong S Kim, Pil Hyung Lee, Benedicte Lefebvre, Jason Nelson, Jean-Louis Mas, Heinrich P Mattle, Bernhard Meier, Mark Reisman, Richard W Smalling, Lars Sondergaard, Jae-Kwan Song, David E Thaler : Patent Foramen Ovale Closure in Stroke and the PASCAL Classification System. JAMA Neurology January 2026 Notes: doi: 10.1001/jamaneurol.2025.5446.
Wonyoung Jung, Kyunga Ko, Amanda M Smith, Anran Huang, Congying Xia, Yehoda M Martei, Vivek K Narayan, Amy S Clark, Benedicte Lefebvre, Kellie McDermott, Daniel Koropeckyj-Cox, Omotayo Fasan, Alexander Hutsell, Amber Daniels, Virginia Englefield, Kasey J Leger, Kelly D Getz, Hari K Narayan, Julian D Marshall, Tiffany M Powell-Wiley, Clyde W Yancy, Bonnie Ky : Air Pollution and Cardiac Remodeling and Function in Patients With Breast Cancer. JAMA Netw Open 9(1), January 2026 Notes: DOI: 10.1001/jamanetworkopen.2025.52323.
Ivy S Han, Kyunga Ko, Jennifer Wei Zou, Amanda M Smith, Nikhil Yegya-Raman, Amber Daniels, Carla Triolo, Congying Xia, Raymond H Mak, Christian Guthier, Gerard Walls, Clifford Robinson, Michael Soike, Adam J Kole, Nitin Ohri, Salma K Jabbour, Marcelo F Di Carli, Paco Bravo, Joshua D Mitchell, Benedicte Lefebvre, Nicholas S Wilcox, Kai Yi Wu, Jeffrey D Bradley, Steven J Feigenberg, Bonnie Ky : Changes in Cardiac Function in Patients Receiving Radiation Therapy for Lung Cancer. Journal of Thoracic Oncology January 2026 Notes: DOI: 10.1016/j.jtho.2026.01.002.
Yu Kang, Benedicte Lefebvre, Amanda Smith, Daniel Koropeckyj-Cox, Priya Brahmbhatt, Bonnie Ky, Joseph Carver, Shannon McCurdy, Selina Luger, Marielle Scherrer-Crosbie: Major Adverse Cardiovascular Events and Cardiac Dysfunction in Patients With Acute Leukemia: A Prospective Study. JACC CardioOncology January 2026 Notes: DOI: 10.1016/j.jaccao.2025.11.004.
Lefebvre, Scherrer-Crosbie: Hematology: Basic Principles and Practice Chapter: Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments. Textbook 2026.
Lefebvre, Carver: European Society of Cardiology, Textbook of Cardiovascular Medicine, 4th Edition. Textbook. Oxford University Press, 2026 Notes: Fluoropyrimidine Chemotherapy, Chapter submitted.
Congying Xia, Amanda M Smith, Bénédicte Lefebvre, Faizi A Jamal, Saro H Armenian, Daniel Koropeckyj-Cox, Liyong Zhang, Peter P Liu, Daniel Landsburg, Amy S Clark, Payal D Shah, Rebecca A Hubbard, Anran Huang, Sophia Golec, Maureen Hewitt, Nicholas S Wilcox, Zhen Chen, Leah Rethy, Wonyoung Jung, Kyunga Ko, Vivek Narayan, Yehoda M Martei, Ninian N Lang, James L Januzzi, G Michael Felker, Bonnie Ky: Biomarker-Guided Cardioprotection for Patients Treated With Anthracyclines: A Randomized Clinical Trial. JAMA Network Open 8(12), December 2025 Notes: DOI: 10.1001/jamanetworkopen.2025.46201.
Eva Berlin, Kyunga Ko, Lin Ma, Ian Messing, Casey Hollawell, Amanda M Smith, Neil K Taunk, Vivek Narayan, Jenica N Upshaw, Amy S Clark, Payal D Shah, Hayley Knollman, Saveri Bhattacharya, Daniel Koropeckyj-Cox, Jessica Wang, Nikhil Yegya-Raman, Ivy S Han, Benedicte Lefebvre, Tang Li, Nicholas S Wilcox, Wonyoung Jung, Jinbo Chen, Gary M Freedman, Bonnie Ky : Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy. JACC CardioOncology 7(3): 219-230, April 2025 Notes: DOI: 10.1016/j.jaccao.2025.01.012.
Azin Vakilpour, Yulei Cao, Benedicte Lefebvre, Srinivas Denduluri, Amanda M Smith, Marielle Scherrer-Crosbie: CARDIOVASCULAR ADVERSE EVENTS AFTER BORTEZOMIB THERAPY IN PATIENTS WITH MULTIPLE MYELOMA: A LARGE REAL-WORLD DATA ANALYSIS. Journal of the American College of Cardiology April 2025.