Benedicte Lefebvre, MD
Assistant Professor of Clinical Medicine (Cardiovascular Medicine)
Adult Scientific Assistant Director, Cardiovascular Phenotyping Unit, Center for Human Phenomic Science, University of Pennsylvania, Perelman School of Medicine
Fellowship Director, Thalheimer Center for Cardio-Oncology, University of Pennsylvania, Perelman School of Medicine
Department: Medicine
Contact information
11-134 South Pavilion
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
Education:
Pre-Univ (Health Sciences)
Collège Laflèche, Canada, 2007.
Pre-Med (Preparatory Medicine)
McGill University, Canada, 2008.
MD (Doctor of Medicine)
McGill University, Canada, 2012.
Permanent linkPre-Univ (Health Sciences)
Collège Laflèche, Canada, 2007.
Pre-Med (Preparatory Medicine)
McGill University, Canada, 2008.
MD (Doctor of Medicine)
McGill University, Canada, 2012.
Selected Publications
Abhinav Kandala, Amar Rai, Rahul Penumaka, Nicholas S. Wilcox, Benedicte Lefebvre, Michael G. Fradley: Radiomics for the Detection and Prediction of Cardiotoxicity in Patients with Cancer: A Structured Narrative Review. Journal of the American College of Cardiology March 2026 Notes: Abstract accepted at the American College of Cardiology Scientific Session, 2026, New Orleans, LA, USA.Lefebvre, Scherrer-Crosbie: Hematology: Basic Principles and Practice Chapter: Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments. Textbook 2026.
Lefebvre, Carver: European Society of Cardiology, Textbook of Cardiovascular Medicine, 4th Edition. Textbook. Oxford University Press, 2026 Notes: Fluoropyrimidine Chemotherapy, Chapter submitted.
Congying Xia, Amanda M Smith, Bénédicte Lefebvre, Faizi A Jamal, Saro H Armenian, Daniel Koropeckyj-Cox, Liyong Zhang, Peter P Liu, Daniel Landsburg, Amy S Clark, Payal D Shah, Rebecca A Hubbard, Anran Huang, Sophia Golec, Maureen Hewitt, Nicholas S Wilcox, Zhen Chen, Leah Rethy, Wonyoung Jung, Kyunga Ko, Vivek Narayan, Yehoda M Martei, Ninian N Lang, James L Januzzi, G Michael Felker, Bonnie Ky: Biomarker-Guided Cardioprotection for Patients Treated With Anthracyclines: A Randomized Clinical Trial. JAMA Network Open 8(12), December 2025.
Eva Berlin, Kyunga Ko, Lin Ma, Ian Messing, Casey Hollawell, Amanda M Smith, Neil K Taunk, Vivek Narayan, Jenica N Upshaw, Amy S Clark, Payal D Shah, Hayley Knollman, Saveri Bhattacharya, Daniel Koropeckyj-Cox, Jessica Wang, Nikhil Yegya-Raman, Ivy S Han, Benedicte Lefebvre, Tang Li, Nicholas S Wilcox, Wonyoung Jung, Jinbo Chen, Gary M Freedman, Bonnie Ky : Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy. JACC CardioOncology 7(3): 219-230, April 2025.
Matthew A Barrett, Biniyam G Demissei, Ray Hu, Amanda M Smith, Gary Freedman, John Plastaras, Steven Feigenberg, Eva Berlin, Hari K Narayan, Benedicte Lefebvre, Marielle Scherrer Crosbie, Michael Fradley, Joseph Carver, Jinbo Chen, Bonnie Ky: 3D Echocardiographic Phenotyping of Left Ventricular Mechanics and Function With Contemporary Radiation Therapy. Advances in Radiation Oncolology 10(7), April 2025.
Azin Vakilpour, Yulei Cao, Benedicte Lefebvre, Srinivas Denduluri, Amanda M Smith, Marielle Scherrer-Crosbie: CARDIOVASCULAR ADVERSE EVENTS AFTER BORTEZOMIB THERAPY IN PATIENTS WITH MULTIPLE MYELOMA: A LARGE REAL-WORLD DATA ANALYSIS. Journal of the American College of Cardiology April 2025.
Takeshi Onoue, Andrew H Matthews, Azin Vakilpour, Yu Kang, Bénédicte Lefebvre, Amanda M Smith, Shannon R McCurdy, Michael G Fradley, Joseph Carver, Jesse Chittams, Marielle Scherrer-Crosbie: Cardiotoxicity of venetoclax in patients with acute myeloid leukemia: comparison with anthracyclines. Cardio-Oncology 10(75), November 2024.
Yu Kang, Benedicte Lefebvre, Ingrid Marti Pamies, Saar I Gill, Abigail G Doucette, Srinivas Denduluri, Amanda M Smith, Shannon McCurdy, Selina Luger, Joseph Carver, Marielle Scherrer-Crosbie: Symptomatic Heart Failure and Clonal Hematopoiesis-Related Mutations in Patients With Acute Myeloid Leukemia. The American Journal of Cardiology September 2024.
Andy Y Wang, Peter M Rothwell, Jason Nelson, Jeffrey L Saver, Scott E Kasner, John Carroll, Jean-Louis Mas, Geneviève Derumeaux, Gilles Chatellier, Anthony J Furlan, Howard C Herrmann, Peter Jüni, Jong S Kim, Benjamin Koethe, Pil H Lee, Benedicte Lefebvre, Heinrich P Mattle, Bernhard Meier, Mark Reisman, Richard W Smalling, Lars Sondergaard, Jae-Kwan Song, Emanuele Di Angelantonio, Marco DiTullio, Mitchell S V Elkind, Shunichi Homma, Cheryl Jaigobin, Patrik Michel, Marie-Luise Mono, Krassen Nedeltchev, Federica Papetti, Joaquin Serena, Christian Weimar, Linxin Li, Sara Mazzucco, Louise E Silver, David van Klaveren, David E Thaler, David M Kent: Patent Foramen Ovale Closure in Older Patients With Stroke: Patient Selection for Trial Feasibility. Neurology 102(10), May 2024.