Akhilesh Basi Reddy, MA MB BChir PhD
Associate Professor of Pharmacology
Member, Penn Institute of Diabetes and Metabolism (IDOM)
Member, Institute for Translational Medicine and Therapeutics (ITMAT)
Member, Diabetes Research Center
Member, Penn Center for Research on Coronavirus and Other Emerging Pathogens
Member, Circadian rhythms and Sleep Institute (CSI)
Member, Penn Institute of RNA Innovation
Member, Institute of Structural Biology
Department: Systems Pharmacology and Translational Therapeutics
Graduate Group Affiliations
Contact information
10-125 Smilow Center for Translational Research
Philadelphia, PA 19104
Philadelphia, PA 19104
Education:
BA (Medical Sciences Tripos)
University of Cambridge, UK, 1998.
PhD
MRC Laboratory of Molecular Biology, Cambridge, UK, 2003.
MB BChir
University of Cambridge, UK, 2003.
MA
University of Cambridge, UK, 2012.
Permanent linkBA (Medical Sciences Tripos)
University of Cambridge, UK, 1998.
PhD
MRC Laboratory of Molecular Biology, Cambridge, UK, 2003.
MB BChir
University of Cambridge, UK, 2003.
MA
University of Cambridge, UK, 2012.
Description of Clinical Expertise
General NeurologyDescription of Research Expertise
Circadian clocks, Sleep, Metabolism, Neural circuits, Deep LearningSelected Publications
O'Neill, J. S. and A. B. Reddy*: Circadian clocks in human red blood cells. Nature 469(7331): 498-503, 2011.O'Neill, J. S., G. van Ooijen, L. E. Dixon, C. Troein, F. Corellou, F. Y. Bouget, A. B. Reddy* and A. J. Millar*: Circadian rhythms persist without transcription in a eukaryote. Nature 469(7331): 554-558, 2011.
Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, Reddy AB*.: Peroxiredoxins are conserved markers of circadian rhythms. Nature 485(7399): 459-64, 2012.
Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O'Neill JS, Reddy AB.: Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci U S A. 113(36): 10085-90, 2016.
Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB*.: The pentose phosphate pathway regulates the circadian clock. Cell Metabolism 24(3): 462-73, 2016.
Henslee EA, Crosby P, Kitcatt SJ, Parry JSW, Bernardini A, Abdallat RG, Braun G, Fatoyinbo HO, Harrison EJ, Edgar RS, Hoettges KF, Reddy AB, Jabr RI, von Schantz M, O'Neill JS, Labeed FH.: Rhythmic potassium transport regulates the circadian clock in human red blood cells. Nat Communications 8(1): 1978, 2017.
Sandipan Ray*, Utham K. Valekunja*, Alessandra Stangherlin, Steven A. Howell, Ambrosius P. Snijders, Gopinath Damodaran, Akhilesh B. Reddy: Circadian rhythms in the absence of the clock gene Bmal1. Science 367(6479): 800-806, 2020.
Ratnasekhar Ch, Guillaume Rey, Sandipan Ray, Pawan K. Jha, Paul C. Driscoll, Mariana Silva Dos Santos, Dania M. Malik, Radoslaw Lach, Aalim M. Weljie, James I. MacRae, Utham K. Valekunja, and Akhilesh B. Reddy: Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells Nature Communications 12(1), 2021.
Pawan K Jha, Utham K Valekunja, Sandipan Ray, Mathieu Nollet, Akhilesh B Reddy : Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep. Nat Commun Biol 5(1): 846, 2022.