Veronique M Lefebvre, PhD
Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Contact information
Translational Program in Pediatric Orthopaedics
Department of Surgery/Division of Orthopaedic Surgery
Children's Hospital of Philadelphia
3615 Civic Center Blvd
Abramson Research Building, 907a
Philadelphia, PA 19104
Department of Surgery/Division of Orthopaedic Surgery
Children's Hospital of Philadelphia
3615 Civic Center Blvd
Abramson Research Building, 907a
Philadelphia, PA 19104
Office: 215-590-0146
Email:
LEFEBVREV1@EMAIL.CHOP.EDU
LEFEBVREV1@EMAIL.CHOP.EDU
Education:
B.S. (Zoology, Molecular Genetics)
Université Catholique de Louvain, Belgium, 1982.
Ph.D. (Cell Biology, Biochemistry)
Université Catholique de Louvain, Belgium, 1990.
Permanent linkB.S. (Zoology, Molecular Genetics)
Université Catholique de Louvain, Belgium, 1982.
Ph.D. (Cell Biology, Biochemistry)
Université Catholique de Louvain, Belgium, 1990.
Selected Publications
Lefebvre Véronique, Angelozzi Marco, Haseeb Abdul: SOX9 in cartilage development and disease. Current opinion in cell biology 61: 39-47, Aug 2019.Angelozzi Marco, Lefebvre Véronique: SOXopathies: Growing Family of Developmental Disorders Due to SOX Mutations. Trends in genetics : TIG Jul 2019.
Haseeb Abdul, Lefebvre Véronique: The SOXE transcription factors-SOX8, SOX9 and SOX10-share a bi-partite transactivation mechanism. Nucleic acids research 47(13): 6917-6931, Jul 2019.
Zawerton Ash, Yao Baojin, Yeager J Paige, Pippucci Tommaso, Haseeb Abdul, Smith Joshua D, Wischmann Lisa, Kühl Susanne J, Dean John C S, Pilz Daniela T, Holder Susan E, McNeill Alisdair, Graziano Claudio, Lefebvre Véronique: De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism. American journal of human genetics 104(4): 777, Apr 2019.
Lefebvre Véronique: Roles and regulation of SOX transcription factors in skeletogenesis. Current topics in developmental biology 133: 171-193, 2019.
Tanaka Shigeru, Suto Akira, Iwamoto Taro, Kageyama Takahiro, Tamachi Tomohiro, Takatori Hiroaki, Suzuki Kotaro, Hirose Koichi, Ohara Osamu, Lefebvre Véronique, Nakajima Hiroshi: Sox12 promotes T reg differentiation in the periphery during colitis. The Journal of experimental medicine 215(10): 2509-2519, Oct 2018.
Sarvestani Samaneh K, Signs Steven A, Lefebvre Veronique, Mack Stephen, Ni Ying, Morton Andrew, Chan Ernest R, Li Xiaoxia, Fox Paul, Ting Angela, Kalady Matthew F, Cruise Michael, Ashburn Jean, Stiene Jennifer, Lai Wei, Liska David, Xiang Shao, Huang Emina H: Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids. Oncotarget 9(47): 28717-28730, Jun 2018.
Bhattaram P, Muschler G, Wixler V, Lefebvre V. : Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast-like synoviocytes in arthritic disease. Arthritis Rheumatology 70: 371-382, March 2018.
Neirijnck Y, Reginensi A, Renkema KY, Massa F, Kozlov VM, Dhib H, Bongers EM, Feitz WF, van Eerde AM, Lefebvre V, Knoers NV, Tabatabaei M, Schulz H, McNeill H, Schaefer F, Wegner M, Sock E, Schedl A.: Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT). Kidney International [Epub ahead of print]: [Epub ahead of print] February 2018 Notes: Epub ahead of print.
Ferguson J, Devarajan M, DiNuoscio G, Saiakhova A, Liu CF, Lefebvre V, Scacheri P, Atit RP. : PRC2 is dispensable in vivo for beta-catenin-mediated repression of chondrogenesis in mouse embryonic cranial mesenchyme. G3 8: 491-503, February 2018.