Peter B. Noël, M.S., Ph.D.

Associate Professor of Radiology
Director of CT Research, Department of Radiology
Co-Director, Center for Imaging Research with Radiation in Radiology (CIR³)
Co-Director, Center for Advanced Computed Tomography Imaging Services (CACTIS)
Department: Radiology
Contact information
Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, One Silverstein
Philadelphia, PA 19104
Department of Radiology
3400 Spruce Street, One Silverstein
Philadelphia, PA 19104
Office: +1 (215) 898-8212
Publications
Links
Search PubMed for articles
Laboratory for Advanced Computed Tomography Imaging
Google Scholar
PixelPrint - lifelike computed tomography (CT) phantoms
Search PubMed for articles
Laboratory for Advanced Computed Tomography Imaging
Google Scholar
PixelPrint - lifelike computed tomography (CT) phantoms
Education:
B. Eng. (Biomedical Engineering)
Technische Hochschule Mittelhessen, Gießen, Germany, 2003.
M. Eng. (Biomedical Engineering)
Technische Hochschule Mittelhessen, Gießen, Germany, 2004.
M.S. (Computer Science and Engineering)
University at Buffalo, The State University of New York, Buffalo, NY, United States, 2007.
Ph.D. (Computer Science and Engineering)
University at Buffalo, The State University of New York, Buffalo, NY, United States, 2009.
Permanent linkB. Eng. (Biomedical Engineering)
Technische Hochschule Mittelhessen, Gießen, Germany, 2003.
M. Eng. (Biomedical Engineering)
Technische Hochschule Mittelhessen, Gießen, Germany, 2004.
M.S. (Computer Science and Engineering)
University at Buffalo, The State University of New York, Buffalo, NY, United States, 2007.
Ph.D. (Computer Science and Engineering)
University at Buffalo, The State University of New York, Buffalo, NY, United States, 2009.
Description of Research Expertise
For over a decade Dr. Noël directs a research program with a broad focus on developing x-ray and Computed Tomography (CT) technology. A central component of his research is the harmonization between hardware and software, reconstruction, and post-processing to achieve integrated clinical solutions. He has built an extensive foundation for facilitating the clinical translation of novel diagnostic imaging technology; one example is the introduction of photon-counting CT. A parallel effort is the development of novel 3D printed CT phantoms, which serve as a central ingredient for clinical and research tasks around evaluation and standardization. Recently he and his team introduced patient-specific lung phantoms, which are available to the larger research community. On the other end of the spectrum, his research program contributes to basic x-ray physics questions focusing on phase-contrast and dark-field imaging. His publication record not only includes more than 190 peer-reviewed publications in international journals, but also a patent portfolio in the areas of x-ray and CT imaging.Selected Publications
Rosario-Berríos DN, Pang A, Liu LP, Maidment PSN, Kim J, Yoon S, Nieves LM, Mossburg KJ, Adezio A, Noël PB, Lennon EM, Cormode DP: The Effect of the Size of Gold Nanoparticle Contrast Agents on CT Imaging of the Gastrointestinal Tract and Inflammatory Bowel Disease. Bioconjug Chem 36(2): 233-244, Feb 2025 Notes: doi: 10.1021/acs.bioconjchem.4c00507. Epub 2025 Jan 9.Liu, L. P., Pasyar, P., Liu, F., Cao, Q., Sandvold, O. F., Sahbaee, Shinohara, T., P., Litt, H. I., & Noël, P. B. : Assessing the Stability of Photon-Counting CT: Insights from a Two-Year Longitudinal Study. European Radiology Dec 2024 Notes: doi: 10.1007/s00330-024-11244-y. Epub ahead of print.
Liu, L. P., Pua, R., Dieckmeyer, M., Shapira, N., Sahbaee, P., Gang, G. J., Litt, H., & Noël, P. B.: Impact of patient habitus and acquisition protocol on iodine quantification in dual source photon-counting CT. Journal of Medical Imaging (Bellingham) 11(Suppl 1): S12806, Dec 2024 Notes: doi: 10.1117/1.JMI.11.S1.S12806. Epub 2024 Jul 26.
Salazar, E., Liu, L. P., Perkins, A. E., Halliburton, S. S., Shapira, N., Litt, H. I., & Noël, P. B.: Impact of scatter radiation on spectral quantification performance of first- and second-generation dual-layer spectral computed tomography. Journal of Applied Clinical Medical Physics 25(7): e14383, Jul 2024 Notes: doi: 10.1002/acm2.14383. Epub 2024 May 27.
Im, J. Y., Halliburton, S., Mei, K., Perkins, A. E., Wong, E., Roshkovan, L., Sandvold, O. F., Liu, L. P., Gang. G. J., & Noël, P. B. : Patient-derived PixelPrint phantoms for evaluating clinical imaging performance of a deep learning CT reconstruction algorithm. Physics in Medicine and Biology 69(11): 115009, May 2024 Notes: doi: 10.1088/1361-6560/ad3dba
Shunhavanich, P., Mei, K., Shapira, N., Stayman, J. W., McCollough, C. H., Gang, G., Noël, P. B., & Hsieh, S. S. : 3D printed phantom with 12 000 submillimeter lesions to improve efficiency in CT detectability assessment. Medical physics 51(5): 3265-3274, May 2024 Notes: doi: 10.1002/mp.17064. Epub 2024 Apr 8.
Liu, L. P., Shapira, N., Halliburton, S. S., Meyer, S., Perkins, A., Litt, H. I., Kauczor, H.U., Leiner, T., Stiller, W., & Noël, P. B. : Spectral performance evaluation of a second-generation spectral detector CT. Journal of Applied Clinical Medical Physics 25(4): e14300, Apr 2024 Notes: doi: 10.1002/acm2.14300. Epub 2024 Feb 22.
Liu, L. P., Pua, R., Rosario-Berrios, D. N., Sandvold, O. F., Perkins, A. E., Cormode, D. P., Shapira, N., Soulen, M., & Noël, P. B.: Reproducible spectral CT thermometry with liver-mimicking phantoms for image-guided thermal ablation. Physics in Medicine & Biology 69(4): 045009, Feb 2024 Notes: doi: 10.1088/1361-6560/ad2124.
Donuru, A., Araki, T., Dako, F., Dave, J. K., Perez, R. P., Xu, D., Nachiapan, A., Barbosa, E. M., Noël, P. B., Litt, H., & Knollman, F. : Photon-counting detector CT allows significant reduction in radiation dose while maintaining image quality and noise on non-contrast chest CT. European Journal of Radiology Open 11: 100538, Nov 2023 Notes: doi: 10.1016/j.ejro.2023.100538.
Sauter, A. P., Proksa, R., Knipfer, A., Reischl, S., Braren, R. F., Nadjiri, J., Kopp, K., Noël, P. B., Makowski, M., Rummeny, E. J., & Fingerle, A. A.: CT-Guided Liver Biopsy: Evaluation of Spectral Data From Dual-Layer Detector CT for Improved Lesion Detection. Cardiovascular and Interventional Radiology 46(11): 1621-1631, Nov 2023 Notes: doi: 10.1007/s00270-023-03550-7. Epub 2023 Sep 27.