Yi-Wei Chang, Ph.D.

faculty photo
Assistant Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics

Contact information
Department of Biochemistry and Biophysics
Perelman School of Medicine
University of Pennsylvania
913B Stellar-Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104-6059
Office: (215) 898-7789
Lab: (215) 898-1191
Education:
B.S. (Mechanical Engineering )
Chung Hua University, Taiwan, 2004.
Ph.D. (Structural Biology )
Academia Sinica & National Tsing Hua University, Taiwan, 2010.
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Description of Research Expertise

structural biology;
cryo-EM;
electron cryotomography (cryo-electron tomography);
correlative light and electron microscopy;
microbiology;
host-pathogen interaction;
pathogen/pathogenesis

Selected Publications

Min Xu, Jitin Singla, Elitza I. Tocheva, Yi-Wei Chang, Raymond C. Stevens, Grant J. Jensen, Frank Alber : De Novo Structural Pattern Mining in Cellular Electron Cryotomograms. Structure April 2019.

Lam Thanh Nguyen, Catherine M Oikonomou, H Jane Ding, Mohammed Kaplan, Qing Yao, Yi-Wei Chang, Morgan Beeby, Grant J Jensen: Simulations suggest a constrictive force is required for Gram-negative bacterial cell division. Nature Communications 10: 1259, March 2019.

Debnath Ghosal, Mohammed Kaplan, Yi-Wei Chang, Grant J. Jensen: In Situ Imaging and Structure Determination of Bacterial Toxin Delivery Systems Using Electron Cryotomography. Methods in Molecular Biology Humana Press, New York, NY, 1921: 249-265, January 2019.

Debnath Ghosal, Kwang Cheol Jeong, Yi-Wei Chang, Jacob Gyore, Lin Teng, Adam Gardner, Joseph P Vogel, Grant Jensen: Molecular architecture of the Legionella Dot/Icm type IV secretion system. Nature Microbiology 2019.

Yi-Wei Chang*, Carrie L Shaffer*, Lee A Rettberg, Debnath Ghosal, Grant J Jensen: In vivo structures of the Helicobacter pylori cag type IV secretion system Cell Reports. Cell Press, 23(3): 673-681, April 2018.

Poorna Subramanian, Sahand Pirbadian, Mohamed Y. El-Naggar, and Grant J. Jensen: Ultrastructure of Shewanella oneidensis MR-1 nanowires revealed by electron cryotomography. Proceedings of the National Academy of Sciences. National Acad Sciences, 115(14): E3246-E3255, April 2018.

Megan J Dobro, Catherine M Oikonomou, Aidan Piper, John Cohen, Kylie Guo, Taylor Jensen, Jahan Tadayon, Joseph Donermeyer, Yeram Park, Benjamin A Solis, Andreas Kjær, Andrew I Jewett, Alasdair W McDowall, Songye Chen, Yi-Wei Chang, Jian Shi, Poorna Subramanian, Cristina V Iancu, Zhuo Li, Ariane Briegel, Elitza I Tocheva, Martin Pilhofer, Grant J Jensen: Uncharacterized bacterial structures revealed by electron cryotomography. Journal of Bacteriology. American Society for Microbiology, 199(17): e00100-17, September 2017.

Ariane Briegel, Catherine M Oikonomou, Yi-Wei Chang, Andreas Kjær, Audrey N Huang, Ki Woo Kim, Debnath Ghosal, Hong H Nguyen, Dorothy Kenny, Rachel R Ogorzalek Loo, Robert P Gunsalus, Grant J Jensen: Morphology of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis. EMBO reports. EMBO Press, 18(9): 1660-1670, September 2017.

Kwangcheol C Jeong, Debnath Ghosal, Yi-Wei Chang, Grant J Jensen, Joseph P Vogel: Polar delivery of Legionella type IV secretion system substrates is essential for virulence. Proceedings of the National Academy of Sciences 114(30): 8077-8082, July 2017.

Yi-Wei Chang, Lee A Rettberg, Davi R Ortega, Grant J Jensen: In vivo structures of an intact type VI secretion system revealed by electron cryotomography. EMBO reports. EMBO Press, Page: e201744072, May 2017.

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Last updated: 04/16/2019
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