Yi-Wei Chang, Ph.D.

faculty photo
Assistant Professor of Biochemistry and Biophysics
Associate Director, Institute of Structural Biology
Department: Biochemistry and Biophysics

Contact information
Department of Biochemistry and Biophysics
Perelman School of Medicine
University of Pennsylvania
913B Stellar-Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104-6059
Office: (215) 898-7789
Lab: (215) 898-1191
B.S. (Mechanical Engineering )
Chung Hua University, Taiwan, 2004.
Ph.D. (Structural Biology )
Academia Sinica & National Tsing Hua University, Taiwan, 2010.
Cert. (Research Mentor Training: Effective Communication and Aligning Expectations)
Perelman School of Medicine, University of Pennsylvania, 2022.
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Description of Research Expertise

Structural biology;
Cryo-electron microscopy;
Cryo-electron tomography;
Correlative light and electron microscopy;
Cellular imaging;
Host-pathogen interaction

Selected Publications

Matthew Martinez†, Shrawan Kumar Mageswaran†, Amandine Guérin, William David Chen, Cameron Thompson, Sarbin Chavin, Dominique Soldati-Favre, Boris Striepen, Yi-Wei Chang: Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed by cryo-electron tomography. Nature Communications 14: 4800, August 2023.

Xiangrui Zeng, Anson Kahng, Liang Xue, Julia Mahamid, Yi-Wei Chang, Min Xu: High-throughput cryo-ET structural pattern mining by unsupervised deep iterative subtomogram clustering. Proceedings of the National Academy of Sciences 120: e2213149120, April 2023.

Longsheng Lai, Yee-Wai Cheung, Matthew Martinez, Kathryn Kixmoeller, Leon Palao III, Stefan Steimle, Meng-Chiao Ho, Ben E Black, Erh-Min Lai, and Yi-Wei Chang: In situ structure determination of bacterial surface nanomachines using cryo-electron tomography. Methods in Molecular Biology. Humana Press, New York, NY, February 2023.

Jose J. Gorbea Colón†, Leon Palao III†, Shin-Fu Chen, Hee Jong Kim, Laura Snyder, Yi-Wei Chang*, Kuang-Lei Tsai*, Kenji Murakami*: Structural basis of a transcription pre-initiation complex on a divergent promoter. Molecular Cell February 2023.

Matthew Martinez, William David Chen, Marta Cova, Petra Andrea Molnár, Shrawan Kumar Mageswaran, Amandine Guérin, Audrey Ragan Odom John, Maryse Lebrun, Yi-Wei Chang: Rhoptry secretion system structure and priming in Plasmodium falciparum revealed using in situ cryo-electron tomography. Nature Microbiology 7: 1230-1238, August 2022.

Daniela Sparvoli†, Jason Delabre†, Diana Marcela Penarete-Vargas§, Shrawan Kumar Mageswaran§, Lev M. Tsypin, Justine Heckendorn, Liam Theveny, Marjorie Maynadier, Marta Mendonça Cova, Laurence Berry-Sterkers, Amandine Guérin, Jean-François Dubremetz, Serge Urbach, Boris Striepen, Aaron P. Turkewitz, Yi-Wei Chang, Maryse Lebrun: An apical membrane complex controls rhoptry exocytosis and invasion in Toxoplasma. EMBO Journal 41: e111158, October 2022.

Liam Theveny†, Shrawan Kumar Mageswaran†, William David Chen, Matthew Martinez, Amandine Guérin, Yi-Wei Chang: Parasitology meets cryo-electron tomography - exciting prospects await. Trends in Parasitology 38(5): 365-378, May 2022.

Shrawan Kumar Mageswaran, Amandine Guérin†, Liam M. Theveny†, William David Chen†, Matthew Martinez, Maryse Lebrun, Boris Striepen, Yi-Wei Chang: In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems. Nature Communications 12: 4983, August 2021.

Eleonora Aquilini†, Marta Mendonça Cova†, Shrawan Kumar Mageswaran, Nicolas Dos Santos Pacheco, Daniela Sparvoli, Diana Marcela Penarete-Vargas, Rania Najm, Arnault Graindorge, Catherine Suarez, Marjorie Maynadier, Laurence Berry-Sterkers, Serge Urbach, Pilar Ruga Fahy, Amandine Guérin, Boris Striepen, Jean-François Dubremetz, Yi-Wei Chang, Aaron Turkewitz, Maryse Lebrun: An Alveolata secretory machinery adapted to parasite host cell invasion. Nature Microbiology 6: 425–434, January 2021.

Yi-Wei Chang, Songye Chen, Elitza I Tocheva, Anke Treuner-Lange, Stephanie Löbach, Lotte Søgaard-Andersen, Grant J Jensen: Correlated cryogenic photoactivated localization microscopy and cryo-electron tomography. Nature methods 11(7): 737, July 2014.

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Last updated: 01/13/2024
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