L. Charles Bailey, MD, PhD

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Associate Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Attending Physician, Department of Pediatrics, Children's Hospital of Philadelphia
Member, Center for Biomedical and Health Informatics, Children's Hospital of Philadelphia
Attending Physician, Department of Pediatrics, Hospital of the University of Pennsylvania & Pennsylvania Hospital
Department: Pediatrics

Contact information
Children's Hospital of Philadelphia
11360 Roberts Center for Pediatric Research
2716 South Street
Philadelphia, PA 19146-2305
Office: (267) 426-1389
Fax: (215) 590-4183
A.B. (Classics & Biochemistry)
Washington University in St. Louis, 1986.
M.D. (Medicine)
University of Pennsylvania School of Medicine, 1998.
Ph.D. (Cellular & Molecular Biology)
University of Pennsylvania School of Medicine, 1998.
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Description of Research Expertise

Our research is based on the proposition that the quality of pediatric health care, and the overall health of children, can be improved by intelligent use of clinical and research information. Large and rapidly growing pools of information about current clinical practice already exist in electronic form; their use is limited by differences in data models, and the lack of pathways to securely retrieve and analyze data. Increasing use of the electronic health record in clinical settings provides both a richer variety of accessible data, and an opportunity to provide intelligent decision support to clinicians at the point of care.

We are developing new ways to translate information into better care at several levels:
- Building accurate and complete sets of clinical data for large pediatric populations. This includes work on constructing a comprehensive data trust within the CHOP network, to serve as infrastructure for many decision support projects, and the establishment of a multicenter collaborative for exchange of pediatric health data.

- Developing tools to improve utility of information and decision support at the point of care. Work here includes development of a clinical episode grouper, with initial deployment to primary care practices in a trial of decision support for treatment of otitis media. We are also developing an electronic system to track chemotherapy planning and delivery for oncology patients, in order to improve safety in this practice.

- Analyzing the impact of clinical decision support on practice. Both the otitis media and chemotherapy tracking projects include an assessment of changes in practice patterns and error rates after the decision support intervention becomes available.

Description of Clinical Expertise

Dr. Bailey is a member of the Divisions of Oncology and Hematology at CHOP.

As part of the general oncology group, he cares for patients with a variety of tumors. His focus is on leukemia and lymphoma, and particularly on acute lymphoblastic leukemia, the most common type of childhood cancer. In addition to caring for patients on the inpatient service and in clinic, Dr. Bailey serves as part of the steering committee for the division's Leukemia/Lymphoma Group.

Dr. Bailey's practice in hematology includes patients with sickle cell disease, bleeding or clotting disorders, bone marrow failure, and general hematologic problems. His special interests are in sickle cell disease and bone marrow failure. He attends on both the inpatient service and in clinic.

Description of Other Expertise

Clinical information systems, especially the electronic health record, provide an unparalleled opportunity to improve care through decision support. However, taking advantage of this opportunity requires a carefully designed information technology infrastructure. In order to help realize this, Dr. Bailey is involved in the building of the Epicare electronic health record for acute care at CHOP, and particularly in its implementation for Oncology patients, including the Beacon chemotherapy management module.

Dr. Bailey also sits on the hospital's Clinical Decision Support committee, and the Division of Oncology's chemotherapy safety and quality improvement committees.

Selected Publications

Chou ST, Khandros E, Bailey LC, Nichols KE, Vakoc CR, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ: Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood 114(5): 983-94, Jul 2009.

Bailey, LC, Reilly, AF, Rheingold, SR: Infections in Pediatric Patients with Hematologic Malignancies. Seminars in Hematology 46(3): 313-24, July 2009.

Bailey L Charles, Lange Beverly J, Rheingold Susan R, Bunin Nancy J: Bone-marrow relapse in paediatric acute lymphoblastic leukaemia. The lancet oncology 9(9): 873-83, Sep 2008.

Master Stephen R, Stoddard Alexander J, Bailey L Charles, Pan Tien-Chi, Dugan Katherine D, Chodosh Lewis A: Genomic analysis of early murine mammary gland development using novel probe-level algorithms. Genome biology 6(2): R20, Feb 2005.

Bailey L C, Searls D B, Overton G C: Analysis of EST-driven gene annotation in human genomic sequence. Genome research 8(4): 362-76, Apr 1998.

Bailey L C, Fischer S, Schug J, Crabtree J, Gibson M, Overton G C: GAIA: framework annotation of genomic sequence. Genome research 8(3): 234-50, Mar 1998.

Bedian V, Adams T, Geiger E A, Bailey L C, Gasser D L: A gene belonging to the Sm family of snRNP core proteins maps within the mouse MHC. Immunogenetics 46(5): 427-30, 1997.

Budarf M L, Collins J, Gong W, Roe B, Wang Z, Bailey L C, Sellinger B, Michaud D, Driscoll D A, Emanuel B S: Cloning a balanced translocation associated with DiGeorge syndrome and identification of a disrupted candidate gene. Nature genetics 10(3): 269-78, Jul 1995.

Feldman G J, Robin N H, Brueton L A, Robertson E, Thompson E M, Siegel-Bartelt J, Gasser D L, Bailey L C, Zackai E H, Muenke M: A gene for cleidocranial dysplasia maps to the short arm of chromosome 6. American journal of human genetics 56(4): 938-43, Apr 1995.

Attree O, Olivos I M, Okabe I, Bailey L C, Nelson D L, Lewis R A, McInnes R R, Nussbaum R L: The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase. Nature 358(6383): 239-42, Jul 1992.

Schnur R E, Wick P A, Bailey C, Rebbeck T, Weleber R G, Wagstaff J, Grix A W, Pagon R A, Hockey A, Edwards M J: Phenotypic variability in X-linked ocular albinism: relationship to linkage genotypes. American journal of human genetics 55(3): 484-96, Sep 1994.

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Last updated: 06/11/2023
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