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Stefan Gysler, MD, MHS, FACOG
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Assistant Professor of Clinical Obstetrics and Gynecology
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Attending Physician, Gynecologic Oncology, Pennsylvania Hospital, Philadelphia, PA
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Attending Physician, Gynecologic Oncology, PENN Presbyterian Medical Center, Philadelphia, PA
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Attending Physician, Gynecologic Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
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Department: Obstetrics and Gynecology
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Contact information
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Division of Gynecologic Oncology
2d Perelman Center for Advanced Medicine
23 3400 Civic Center Boulevard
39 10th Floor South Tower
Philadelphia, PA 19104
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2d Perelman Center for Advanced Medicine
23 3400 Civic Center Boulevard
39 10th Floor South Tower
Philadelphia, PA 19104
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Education:
21 9 BMSc c
3e University of Western Ontario, Canada, 2010.
21 8 MHS c
4a Yale University School of Medicine, New Haven, CT, 2015.
21 7 MD c
4a Yale University School of Medicine, New Haven, CT, 2015.
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Permanent link21 9 BMSc c
3e University of Western Ontario, Canada, 2010.
21 8 MHS c
4a Yale University School of Medicine, New Haven, CT, 2015.
21 7 MD c
4a Yale University School of Medicine, New Haven, CT, 2015.
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17d Nasioudis D, Gysler S, Ko EM, Haggerty AF, Cory L, Giuntoli II RL, Kim SH, Morgan MA, Latif NA: Do patients with FIGO stage II endometrioid endometrial carcinoma benefit from the addition of chemotherapy to adjuvant radiation therapy? Poster, Society of Gynecologic Oncology Annual meeting Mar 2021 *virtual.
169 Nasioudis D, Gysler S, Latif NA, Haggerty AF, Cory L, Giuntoli II RL, Kim SH, Morgan MA, Ko EM: Prevalence of lymph node metastasis and role of lymphadenectomy for apparent early stage ovarian clear cell carcinoma. Poster. Society of Gynecologic Oncology Annual meeting Mar 2021 *virtual.
136 Nasioudis D, Heyward Q, Gysler S, Giuntoli RL, Cory L, Kim S, Morgan MA, Haggerty AF, Ko EM, Latif NA: Is there a benefit of performing an omentectomy for clinical stage I high-grade endometrial carcinoma? Surg Oncol 37:101534, Jun 2021.
19d Latif NA, Gysler S, Haggerty AF, Giuntoli II RL, Ko EM, Cory L: Cytoreductive surgery for advanced-stage ovarian cancer with upper abdominal disease performed by gynecologic oncologists alone versus multiple surgical specialties: Is there a difference in outcomes? Poster, Society of Gynecologic Oncologist Annual Meeting Mar 2020 *virtual.
13c Oh JK, Nasioudis D, Gysler S, Ko EM, Morgan MA, Haggerty AF, Kim SK, Cory L, Latif NA: Use of adjuvant chemotherapy for early-stage low-grade serous ovarian carcinoma. Poster, Society of Gynecologic Oncologist Annual Meeting Mar 2020 *virtual.
146 Nasioudis D, Heyward Q, Gysler S, Giuntoli II RL, Cory L, Kim SH, Morgan MA, Haggerty AF, Ko EM, Latif NA: Is there a benefit of performing omentectomy for stage I high-grade endometrial cancer. Poster, Society of Gynecologic Oncology Apr 2020 *Virtual.
15f Heyward Q, Nasioudis D, Gysler S, Giuntoli II RL, Cory L, Kim SH, Morgan MA, Haggerty AF, Ko EM, Latif NA: Is there any utility in performing lymphadenectomy for early-stage mucinous ovarian carcinoma? Poster, Society of Gynecologic Oncologist Annual Meeting Apr 2020 * virtual.
1a4 Webster EM, Yadav GS, Gysler S, McNamara B, Black J, Tymon-Rosario J, Zeybek B, Han C, Arkfeld CK, Andikyan V, Menderes G, Huang G, Azodi M, Silasi DA, Santin AD, Schwartz PE, Ratner ES, Altwerger G: Prescribed medical cannabis in women with gynecologic malignancies: A single-institution survey-based study. Gynecol Oncol Rep 34:100667, Nov 2020.
103 Menderes G, Gysler SM, Vadivelu N, Silasi DA: Challenges of Robotic Gynecologic Surgery in Morbidly Obese Patients and How to Optimize Success. Curr Pain Headache Rep 23(7):51, Jul 2019.
13d Hui P, Gysler SM, Uduman M, Togun TA, Prado DE, Brambs CE, Nallur S, Schwartz PE, Rutherford TJ, Santin AD, Weidhaas JB, Ratner ES: MicroRNA signatures discriminate between uterine and ovarian serous carcinomas. Hum Pathol 76:133-140, Jun 2018.
17a Feinberg J, Albright B, Black J, Lu L, Passarelli R, Gysler S, Whicker M, Altwerger G, Menderes G, Hui P, Santin AD, Azodi M, Silasi DA, Ratner ES, Litkouhi B, Schwartz PE: Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes. Gynecol Obstet Invest 84(3):290-297, 2019.
143 Menderes G, Lopez S, Han C, Altwerger G, Gysler S, Varughese J, Schwartz PE, Santin AD: Mechanisms of resistance to HER2-targeted therapies in HER2-amplified uterine serous carcinoma, and strategies to overcome it. Discov Med 26(141):39-50, Aug 2018.
126 Tubridy EA, Eiva MA, Liu F, Omran DK, Gysler S, Brown EG, Roy AG, Zeng Y, Oh J, Cao Q, Gitto SB, Powell DJ Jr: CD137+ tumor infiltrating lymphocytes predicts ovarian cancer survival. Gynecol Oncol 25(3):330-345, Mar 2024.
177 Reavis HD, Gysler SM, McKenney GB, Knarr M, Lusk HJ, Rawat P, Rendulich HS, Mitchell MA, Berger DS, Moon JS, Ryu S, Mainigi M, Iwanicki MP, Hoon DS, Sanchez LM, Drapkin R: Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells. JCI Insight 9(5):e170961, Mar 2024.
220 Kader T, Lin JR, Hug CB, Coy S, Chen YA, de Bruijn I, Shih N, Jung E, Pelletier RJ, Lopez Leon M, Mingo G, Omran DK, Lee JS, Yapp C, Satravada BA, Kundra R, Xu Y, Chan S, Tefft JB, Muhlich JL, Kim SH, Gysler SM, Agudo J, Heath JR, Schultz N, Drescher CW, Sorger PK, Drapkin R, Santagata S.: Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma. Cancer Discov Jan 2025.
13a Pepin A, Chesnokova A, Pishko A, Gysler S, Martin C, Smith E, Kassick M, Taunk NK.: Hormone Replacement Therapy in Patients with Gynecologic Cancer and Radiation-Induced Premature Ovarian Insufficiency. Int J Radiat Oncol Biol Phys Oct 2024.
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Selected Publications
d8 Gysler SM, Drapkin R: Tumor innervation: peripheral nerves take control of the tumor microenvironment. J Clin Invest 131(11):e147276, Jun 2021.17d Nasioudis D, Gysler S, Ko EM, Haggerty AF, Cory L, Giuntoli II RL, Kim SH, Morgan MA, Latif NA: Do patients with FIGO stage II endometrioid endometrial carcinoma benefit from the addition of chemotherapy to adjuvant radiation therapy? Poster, Society of Gynecologic Oncology Annual meeting Mar 2021 *virtual.
169 Nasioudis D, Gysler S, Latif NA, Haggerty AF, Cory L, Giuntoli II RL, Kim SH, Morgan MA, Ko EM: Prevalence of lymph node metastasis and role of lymphadenectomy for apparent early stage ovarian clear cell carcinoma. Poster. Society of Gynecologic Oncology Annual meeting Mar 2021 *virtual.
136 Nasioudis D, Heyward Q, Gysler S, Giuntoli RL, Cory L, Kim S, Morgan MA, Haggerty AF, Ko EM, Latif NA: Is there a benefit of performing an omentectomy for clinical stage I high-grade endometrial carcinoma? Surg Oncol 37:101534, Jun 2021.
19d Latif NA, Gysler S, Haggerty AF, Giuntoli II RL, Ko EM, Cory L: Cytoreductive surgery for advanced-stage ovarian cancer with upper abdominal disease performed by gynecologic oncologists alone versus multiple surgical specialties: Is there a difference in outcomes? Poster, Society of Gynecologic Oncologist Annual Meeting Mar 2020 *virtual.
13c Oh JK, Nasioudis D, Gysler S, Ko EM, Morgan MA, Haggerty AF, Kim SK, Cory L, Latif NA: Use of adjuvant chemotherapy for early-stage low-grade serous ovarian carcinoma. Poster, Society of Gynecologic Oncologist Annual Meeting Mar 2020 *virtual.
146 Nasioudis D, Heyward Q, Gysler S, Giuntoli II RL, Cory L, Kim SH, Morgan MA, Haggerty AF, Ko EM, Latif NA: Is there a benefit of performing omentectomy for stage I high-grade endometrial cancer. Poster, Society of Gynecologic Oncology Apr 2020 *Virtual.
15f Heyward Q, Nasioudis D, Gysler S, Giuntoli II RL, Cory L, Kim SH, Morgan MA, Haggerty AF, Ko EM, Latif NA: Is there any utility in performing lymphadenectomy for early-stage mucinous ovarian carcinoma? Poster, Society of Gynecologic Oncologist Annual Meeting Apr 2020 * virtual.
1a4 Webster EM, Yadav GS, Gysler S, McNamara B, Black J, Tymon-Rosario J, Zeybek B, Han C, Arkfeld CK, Andikyan V, Menderes G, Huang G, Azodi M, Silasi DA, Santin AD, Schwartz PE, Ratner ES, Altwerger G: Prescribed medical cannabis in women with gynecologic malignancies: A single-institution survey-based study. Gynecol Oncol Rep 34:100667, Nov 2020.
103 Menderes G, Gysler SM, Vadivelu N, Silasi DA: Challenges of Robotic Gynecologic Surgery in Morbidly Obese Patients and How to Optimize Success. Curr Pain Headache Rep 23(7):51, Jul 2019.
13d Hui P, Gysler SM, Uduman M, Togun TA, Prado DE, Brambs CE, Nallur S, Schwartz PE, Rutherford TJ, Santin AD, Weidhaas JB, Ratner ES: MicroRNA signatures discriminate between uterine and ovarian serous carcinomas. Hum Pathol 76:133-140, Jun 2018.
17a Feinberg J, Albright B, Black J, Lu L, Passarelli R, Gysler S, Whicker M, Altwerger G, Menderes G, Hui P, Santin AD, Azodi M, Silasi DA, Ratner ES, Litkouhi B, Schwartz PE: Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes. Gynecol Obstet Invest 84(3):290-297, 2019.
143 Menderes G, Lopez S, Han C, Altwerger G, Gysler S, Varughese J, Schwartz PE, Santin AD: Mechanisms of resistance to HER2-targeted therapies in HER2-amplified uterine serous carcinoma, and strategies to overcome it. Discov Med 26(141):39-50, Aug 2018.
126 Tubridy EA, Eiva MA, Liu F, Omran DK, Gysler S, Brown EG, Roy AG, Zeng Y, Oh J, Cao Q, Gitto SB, Powell DJ Jr: CD137+ tumor infiltrating lymphocytes predicts ovarian cancer survival. Gynecol Oncol 25(3):330-345, Mar 2024.
177 Reavis HD, Gysler SM, McKenney GB, Knarr M, Lusk HJ, Rawat P, Rendulich HS, Mitchell MA, Berger DS, Moon JS, Ryu S, Mainigi M, Iwanicki MP, Hoon DS, Sanchez LM, Drapkin R: Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells. JCI Insight 9(5):e170961, Mar 2024.
220 Kader T, Lin JR, Hug CB, Coy S, Chen YA, de Bruijn I, Shih N, Jung E, Pelletier RJ, Lopez Leon M, Mingo G, Omran DK, Lee JS, Yapp C, Satravada BA, Kundra R, Xu Y, Chan S, Tefft JB, Muhlich JL, Kim SH, Gysler SM, Agudo J, Heath JR, Schultz N, Drescher CW, Sorger PK, Drapkin R, Santagata S.: Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma. Cancer Discov Jan 2025.
13a Pepin A, Chesnokova A, Pishko A, Gysler S, Martin C, Smith E, Kassick M, Taunk NK.: Hormone Replacement Therapy in Patients with Gynecologic Cancer and Radiation-Induced Premature Ovarian Insufficiency. Int J Radiat Oncol Biol Phys Oct 2024.
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