Aime T. Franco, Ph.D.

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
ARC 803-Lab
ARC 816C-Office
Philadelphia, PA 19104
Office: 215-590-1066
Education:
B.S./B.A. (B.S. Sports Medicine and Athletic Training; B.A. Biology)
University of Connecticut, 2000.
M.S. (Nutritional Sciences)
University of Connecticut, 2002.
Ph.D. (Cancer Biology)
Vanderbilt University, 2007.
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Description of Research Expertise

Thyroid Cancer, Tumor Microenvironment, mouse models of cancer, transgenic mouse models

Selected Publications

Franco AT, Labourier E, Adlordeppey KK, Surrey LF, Mostoufi-Moab S, Isaac A, Adzick NS, Kazahaya K, Kumar G, Bauer AJ: "miRNA expression can classify pediatric thyroid lesions and increases the diagnostic yield of mutation testing" Pediatr Blood Cancer 67(6): e28276, June 2020.

Laura MacDonald, Jonathan Jenkins, Grace Purvis, Joshua Lee, Aime T Franco: The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication. Horm Cancer 2020.

Jana A, Nookaew I, Singh J, Behkam B, Franco AT, Nain AS: Crosshatch nanofiber networks of tunable interfiber spacing induce plasticity in cell migration and cytoskeletal response. FASEB Journal 2019.

Jolly Lee Ann, Novitskiy Sergey, Owens Phillip, Massoll Nicole, Cheng Nikki, Fang Wei, Moses Harold L, Franco Aime T: Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss. Cancer Research 76(7): 1804-13, Apr 2016.

Jolly Lee Ann, Massoll Nicole, Franco Aime T: Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by Hras and Pten Loss. Journal of clinical & cellular immunology 7(5), Sep 2016 Notes: Epub only.

Hinson AM, Massoll NA, Jolly LA, Stack BC, Bodenner D, Franco AT: Structural Alterations in Tumor-Draining Lymph Nodes Before Papillary Thyroid Carcinoma Metastasis. Head & Neck 39(8): 1639-1646, Aug 2017.

Franco Aime T, Malaguarnera Roberta, Refetoff Samuel, Liao Xiao-Hui, Lundsmith Emma, Kimura Shioko, Pritchard Catrin, Marais Richard, Davies Terry F, Weinstein Lee S, Chen Min, Rosen Neal, Ghossein Ronald, Knauf Jeffrey A, Fagin James A: Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proceedings of the National Academy of Sciences of the United States of America 108(4): 1615-20, Jan 2011.

Chen Xu, Mitsutake Norisato, LaPerle Krista, Akeno Nagako, Zanzonico Pat, Longo Valerie A, Mitsutake Shin, Kimura Edna T, Geiger Hartmut, Santos Eugenio, Wendel Hans G, Franco Aime, Knauf Jeffrey A, Fagin James A: Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proceedings of the National Academy of Sciences of the United States of America 106(19): 7979-84, May 2009.

Ciccarella A, Staley AC, Franco AT: Transforming Research: Engaging patient advocates at all stages of cancer research. Ann Transl Medicine 2018.

Franco Aime T, Corken Adam, Ware Jerry: Platelets at the interface of thrombosis, inflammation, and cancer. Blood 126(5): 582-8, Jul 2015.

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Last updated: 08/15/2020
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