Jerome Clatot, Ph.D.
Research Assistant Professor of Neurology
Research Scientist, The Children's Hospital of Philadelphia
Department: Neurology
Contact information
3615 Civic Center Boulevard
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 2163702395
Email:
CLATOTJ@chop.edu
CLATOTJ@chop.edu
Publications
Education:
Bachelors (Sciences)
Lycee Van Gogh, Ermont, France, 2000.
Masters (Pathophysiology)
Pontoise University, France, 2009.
Ph.D. (Genetic of channelopathies)
University Pierre et Marie Curie, Paris, France, 2012.
Permanent linkBachelors (Sciences)
Lycee Van Gogh, Ermont, France, 2000.
Masters (Pathophysiology)
Pontoise University, France, 2009.
Ph.D. (Genetic of channelopathies)
University Pierre et Marie Curie, Paris, France, 2012.
Description of Research Expertise
My current research focuses on identifying defects in voltage-gated ion channels associated with neuronal diseases and by so doing, identifying the root cause of the disease. This will allow us to develop customized solutions for families afflicted with these syndromes (precision medicine). Genetic and genomic research is quickly transitioning us from a society in which treatment is empiric one-size-fits-all approach to one in which therapy is based on the specific cause of the disease and tailored to the individual patient. This knowledge is ushering in a new era that is changing the face of medicine as we know it today. My research program will increase our understanding of voltage-gated ion channel megacomplex physiology in health and in the disease and delve further new and innovative therapeutical approaches for a class of diseases with no treatment or cure.Selected Publications
Clatot J, Thompson CH, Sotardi S, Jiang J, Trivisano M, Balestrini S, Ward DI, Ginn N, Guaragni B, Malerba L, Vakrinou A, Sherer M, Helbig I, Somarowthu A, Sisodiya SM, Ben-Shalom R, Guerrini R, Specchio N, George AL Jr, Goldberg EM.: Rare dysfunctional SCN2A variants are associated with malformation of cortical development. Epilepsia 66(3): 914-928, Mar 2025.Qu G, Merchant JP, Clatot J, DeFlitch LM, Frederick DJ, Tang S, Salvatore M, Zhang X, Li J, Anderson SA, Goldberg EM.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, Apr 2024.
Feng H, Clatot J, Kaneko K, Flores-Mendez M, Wengert ER, Koutcher C, Hoddeson E, Lopez E, Lee D, Arias L, Liang Q, Zhang X, Somarowthu A, Covarrubias M, Gunthorpe MJ, Large CH, Akizu N, Goldberg EM.: Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy. Cell Rep Med 5(2): 101389, Feb 2024.
Clatot J, Goldberg EM.: No Pain, No Gain of Function: Epilepsy-Associated Variants in SCN2A Defy Classification. Epilepsy Curr 24(2): 126-128, Jan 2024.
Clatot J, Currin CB, Liang Q, Pipatpolkai T, Massey SL, Helbig I, Delemotte L, Vogels TP, Covarrubias M, Goldberg EM.: A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proc Natl Acad Sci U S A 121(3): e2307776121, Jan 2024.
Clatot J, Parthasarathy S, Cohen S, McKee JL, Massey S, Somarowthu A, Goldberg EM, Helbig I.: SCN1A gain-of-function mutation causing an early onset epileptic encephalopathy. Epilepsia 64(5): 1318-1330, May 2023.
Clatot J, Ginn N, Costain G, Goldberg EM.: A KCNC1-related neurological disorder due to gain of Kv3.1 function. Ann Clin Transl Neurol 10(1): 111-117, Jan 2023.
Clatot J, Coulombe A, Deschênes I, Guicheney P, Neyroud N.: Trafficking and Gating Cooperation Between Deficient Na(v)1.5-mutant Channels to Rescue I(Na). Front Biosci (Landmark Ed) 27(7): 209, Jun 2022.
Zhang ZH, Barajas-Martínez H, Xia H, Li B, Capra JA, Clatot J, Chen GX, Chen X, Yang B, Jiang H, Tse G, Aizawa Y, Gollob MH, Scheinman M, Antzelevitch C, Hu D.: Distinct Features of Probands With Early Repolarization and Brugada Syndromes Carrying SCN5A Pathogenic Variants. J Am Coll Cardiol 78(16): 1603-1617, Oct 2021.
Di Diego JM, Patocskai B, Barajas-Martinez H, Borbáth V, Ackerman MJ, Burashnikov A, Clatot J, Li GR, Robinson VM, Hu D, Antzelevitch C.: Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes. PLoS One 15(11): e0242747, Nov 2020.