Nicholas K. Brown, PhD, F(ACHI)

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Assistant Professor of Clinical Pathology and Laboratory Medicine
Associate Director, Histocompatibility Testing Laboratory, Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Founders 7019
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-7789
BA (Biology)
Kalamazoo College, Kalamazoo, MI, 2000.
PhD (Immunology and Microbiology (incl. Research Assistant role))
Wayne State University School of Medicine, Detroit, MI, 2007.
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Selected Publications

Nicholas Brown, Thanh-Mai Bui: An open-source program to gather relevant data for virtual crossmatch. Human Immunology 83(S1): P145, November 2022.

F. Brad Johnson, Sandra Mateu, Edward Vo, Jane Kearns, Thanh-Mai Bui, Nicholas Brown, Malek Kamoun: An unusually well HLA-matched pairing between a homozygous HLA-A*03:02 deceased donor kidney and a highly sensitized patient carrying HLA-A*03:02 and having antibodies to HLA-A*03:01. Human Immunology 83(S1): P33, November 2022.

Nicholas Brown: Applying modern data science tools to aid virtual crossmatch. ASHI Quarterly. American Society for Histocompatibility and Immunogenetics, Q3 2022: 32-35, September 2022 Notes: No issue.

Wang X, Liu M, Zhang J, Brown NK, Zhang P, Zhang Y, Liu H, Du X, Wu W, Devenport M, Tao W, Mao-Draayer Y, Chen GY, Chen YE, Zheng P, Liu Y.: CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder. Cell Metab 34(8): 1088-1103, Aug 2022.

Kamoun M, Askar M, Kearns JD, Bui TM, Nguyen M, Brown NK, Duquesnoy RJ.: Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody. Human Immunology 83(2): 99-106, Feb 2022.

Nicholas Brown, David Porter, Alison Loren, Malek Kamoun, F.Brad Johnson: An HLA-identical child as a donor for hematopoietic cell transplantation: is this a haploidentical or matched-“sibling” transplant? Human Immunology 82(S1): P05, September 2021.

Nicholas Brown , Hui Gao , Thanh-Mai Bui: From zero to hero: use of the statistical programming language R to manage clinical HLA laboratory data by a lab with little programming experience. Human Immunology 82(S1): P109, September 2021.

Nicholas Brown, Bao Ngo, Than-Mai Bui: Logicle scaling for flow cytometric crossmatching increases events of scarce B cells. Human Immunology 82(S1): P86, September 2021.

#Brown NK, Merkens H, Rozemuller EH, Bell D, Bui TM, Kearns J: Reduced PCR-generated errors from a hybrid capture-based NGS assay for HLA typing. Human Immunology 82(4): 296-301, April 2021 Notes: #indicates corresponding author.

Nicholas Brown: R for HLA data Github, 2021 Notes: A collection of computer code, written in R, for extracting and managing HLA data for research and clinical purposes.

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Last updated: 02/28/2023
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