Nicholas K. Brown, PhD, F(ACHI)

Associate Professor of Clinical Pathology and Laboratory Medicine
Associate Director, Histocompatibility Testing Laboratory, Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact information
Founders 7019
3400 Spruce Street
Philadelphia, PA 19104
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-7789
Publications
Education:
BA (Biology)
Kalamazoo College, Kalamazoo, MI, 2000.
PhD (Immunology and Microbiology (incl. Research Assistant role))
Wayne State University School of Medicine, Detroit, MI, 2007.
Permanent linkBA (Biology)
Kalamazoo College, Kalamazoo, MI, 2000.
PhD (Immunology and Microbiology (incl. Research Assistant role))
Wayne State University School of Medicine, Detroit, MI, 2007.
Selected Publications
Dasariraju S, Gragert L, Wager GL, McCullough K, Brown NK, Kamoun M, Urbanowicz RJ: HLA Amino Acid Mismatch-Based Risk Stratification of Kidney Allograft Failure Using a Novel Machine Learning Algorithm. J Biomed Inform 142: 104374, June 2023.Brown NK, Peyster EG, Bui T: R for HLA Data: A Suite of Tools for Managing and Analyzing Data from Clinical HLA Laboratory Information Systems. American Journal of Transplantation 23(6, supplement 1): S756, June 2023.
Potluri V, Naqvi F, Goldberg DS, Shah M, Loupy A, Abt P, Blumberg E, Trofe-Clark J, Bloom R, Sawinski D, Chattergoon M, Segev DL, Bair-Marcantoni N, Durand CM, Reddy R, Levine M, Brown N, Mapchan S, Aubert O, Desai N, Reese PP: Longer-Term Clinical Outcomes From the THINKER and EXPANDERTrials of Transplantation of HCV-RNA+ Donor Kidneys Into Hepatitis C Virus-Negative Recipients. Kidney International Reports April 2023.
Brown, NK: Carving your path through ASHI: An interview with Dr. Nicholas Brown. Coffee & Compatibility Podcast April 2023.
Nicholas Brown, Thanh-Mai Bui: An open-source program to gather relevant data for virtual crossmatch. Human Immunology 83(S1): P145, November 2022.
F. Brad Johnson, Sandra Mateu, Edward Vo, Jane Kearns, Thanh-Mai Bui, Nicholas Brown, Malek Kamoun: An unusually well HLA-matched pairing between a homozygous HLA-A*03:02 deceased donor kidney and a highly sensitized patient carrying HLA-A*03:02 and having antibodies to HLA-A*03:01. Human Immunology 83(S1): P33, November 2022.
Nicholas Brown: Applying modern data science tools to aid virtual crossmatch. ASHI Quarterly. American Society for Histocompatibility and Immunogenetics, Q3 2022: 32-35, September 2022 Notes: No issue.
Wang X, Liu M, Zhang J, Brown NK, Zhang P, Zhang Y, Liu H, Du X, Wu W, Devenport M, Tao W, Mao-Draayer Y, Chen GY, Chen YE, Zheng P, Liu Y.: CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder. Cell Metab 34(8): 1088-1103, Aug 2022.
Kamoun M, Askar M, Kearns JD, Bui TM, Nguyen M, Brown NK, Duquesnoy RJ.: Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody. Human Immunology 83(2): 99-106, Feb 2022.
Nicholas Brown, David Porter, Alison Loren, Malek Kamoun, F.Brad Johnson: An HLA-identical child as a donor for hematopoietic cell transplantation: is this a haploidentical or matched-“sibling” transplant? Human Immunology 82(S1): P05, September 2021.