Nicholas K. Brown, PhD, F(ACHI)
Assistant Professor of Clinical Pathology and Laboratory Medicine
Associate Director, Histocompatibility Testing Laboratory, Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact information
Founders 7019
3400 Spruce Street
Philadelphia, PA 19104
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-7789
Publications
Education:
BA (Biology)
Kalamazoo College, Kalamazoo, MI, 2000.
PhD (Immunology and Microbiology (incl. Research Assistant role))
Wayne State University School of Medicine, Detroit, MI, 2007.
Permanent linkBA (Biology)
Kalamazoo College, Kalamazoo, MI, 2000.
PhD (Immunology and Microbiology (incl. Research Assistant role))
Wayne State University School of Medicine, Detroit, MI, 2007.
Selected Publications
Nicholas Brown, Thanh-Mai Bui: An open-source program to gather relevant data for virtual crossmatch. Human Immunology 83(S1): P145, November 2022.F. Brad Johnson, Sandra Mateu, Edward Vo, Jane Kearns, Thanh-Mai Bui, Nicholas Brown, Malek Kamoun: An unusually well HLA-matched pairing between a homozygous HLA-A*03:02 deceased donor kidney and a highly sensitized patient carrying HLA-A*03:02 and having antibodies to HLA-A*03:01. Human Immunology 83(S1): P33, November 2022.
Nicholas Brown: Applying modern data science tools to aid virtual crossmatch. ASHI Quarterly. American Society for Histocompatibility and Immunogenetics, Q3 2022: 32-35, September 2022 Notes: No issue.
Wang X, Liu M, Zhang J, Brown NK, Zhang P, Zhang Y, Liu H, Du X, Wu W, Devenport M, Tao W, Mao-Draayer Y, Chen GY, Chen YE, Zheng P, Liu Y.: CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder. Cell Metab 34(8): 1088-1103, Aug 2022.
Kamoun M, Askar M, Kearns JD, Bui TM, Nguyen M, Brown NK, Duquesnoy RJ.: Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody. Human Immunology 83(2): 99-106, Feb 2022.
Nicholas Brown, David Porter, Alison Loren, Malek Kamoun, F.Brad Johnson: An HLA-identical child as a donor for hematopoietic cell transplantation: is this a haploidentical or matched-“sibling” transplant? Human Immunology 82(S1): P05, September 2021.
Nicholas Brown , Hui Gao , Thanh-Mai Bui: From zero to hero: use of the statistical programming language R to manage clinical HLA laboratory data by a lab with little programming experience. Human Immunology 82(S1): P109, September 2021.
Nicholas Brown, Bao Ngo, Than-Mai Bui: Logicle scaling for flow cytometric crossmatching increases events of scarce B cells. Human Immunology 82(S1): P86, September 2021.
#Brown NK, Merkens H, Rozemuller EH, Bell D, Bui TM, Kearns J: Reduced PCR-generated errors from a hybrid capture-based NGS assay for HLA typing. Human Immunology 82(4): 296-301, April 2021 Notes: #indicates corresponding author.
Nicholas Brown: R for HLA data https://github.com/users/k96nb01/projects/1. Github, 2021 Notes: A collection of computer code, written in R, for extracting and managing HLA data for research and clinical purposes.