Nicholas K. Brown, PhD, F(ACHI)
Associate Professor of Clinical Pathology and Laboratory Medicine
Associate Director, Histocompatibility Testing Laboratory, Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact information
Founders 7019
3400 Spruce Street
Philadelphia, PA 19104
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-7789
Publications
Education:
BA (Biology)
Kalamazoo College, Kalamazoo, MI, 2000.
PhD (Immunology and Microbiology (incl. Research Assistant role))
Wayne State University School of Medicine, Detroit, MI, 2007.
Permanent linkBA (Biology)
Kalamazoo College, Kalamazoo, MI, 2000.
PhD (Immunology and Microbiology (incl. Research Assistant role))
Wayne State University School of Medicine, Detroit, MI, 2007.
Selected Publications
Bhoj VG, Kaminski M, Zhao H, Jackson K, Wang W, Liu C, Montgomery RA, Ali N, Mangiola M, Spitzer TR, Safa K, Pattanayak V, Taj R, Chiu J, Bui TM, Sonnenberg EM, Markmann JF, Milone MC, June CH, Siegel DL, Fraietta JA, Gonzalez V, Locci M, Palmer M, Monos D, Hwang WT, Sledge T, Bridges ND, Goldstein JS, Odim J, Sweet SC, Besharatian BD, Hussain SM, Brown NK, Kamoun M, Garfall AL, Naji A.: Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy. N Engl J Med 394: 2117-2125, Jun 2026.Spierings E, Brown NK, Latham K, Robinson J, Melchers M, Askar M, Morris GP, Weimer E, Maiers M, Madbouly A.: Recommendations for HLA Genotyping Data Standards and Clinical Laboratory Staffing Considerations. HLA 107(4), April 2026.
Mack SJ, Brown NK, Gragert L, Hofmann JA, Lemieux W, Matern BM, Osoegawa K, Sauter J, Maiers M, Spierings E.: The Phenotype List String Grammar for Enhanced Protein and Antigen Reporting in the Immunogenetic Context. HLA 107(4), April 2026 Notes: https://doi.org/10.1111/tan.70693.
Busra Coskun, Nicholas K Brown: Immunogenetr: a comprehensive toolkit for clinical HLA informatics. Human Immunology 87(1), January 2026 Notes: 10.1016/j.humimm.2025.111619.
Nicholas K. Brown: HLA Testing for Celiac Disease. ASHI Quarterly. American Society for Histocompatibility and Immunogenetics, Q3: 20-24, September 2025.
B. Coskun, N. Brown: immunogenetr: A comprehensive toolkit for clinical HLA informatics. Human Immunology 86(Supplement): 111361, September 2025.
R.J. Urbanowicz, H. Bandhey, A.N. Paynter, N. Brown, K. McCullough, L. Gragert, M. Kamoun c: Identifying HLA amino acid mismatches that predict kidney graft failure with cross validation using FIBERS 2.0 machine learning binning. Human Immunology 86(Supplement): 111353, September 2025.
K. McCullough, K. Hawthorne, L. Gragert, N. Brown, A.N. Paynter, J. Ko, R.J. Urbanowicz, M. Kamoun: Impact of HLA class I amino acid positions that distinguish allele lineages on adjusted hazard ratios of graft failure. Human Immunology 86(Supplement): 111420, September 2025.
K. McCullough, L. Gragert, N. Brown, R. Urbanowicz, H. Bandhey, A. Paynter, J. Ko, M. Kamoun: HLA Class I Amino Acid Mismatches That Distinguish Divergent HLA-A Allele Lineages Confer Incremental Risk of Kidney Allograft Failure Independent of Class II Mismatches. American Journal of Transplantation 25(Issue 8, Supplement 1): S148-S149, August 2025.
Ho S, Hod-Dvorai R, Bravo-Egana V, Kheradmand T, Bishop C, Brown NK, Eilrich H, O'Shields EF, Houp JA, Sanfilippo AM, Timofeeva O; American Society for Histocompatibility and Immunogenetics (ASHI) Professional Standards Division.: Practical guide to personnel competency assessment in clinical histocompatibility laboratories. Hum Immunol 86(4), July 2025.