Audrey Odom John, MD, PhD

faculty photo
Professor of Pediatrics (Infectious Diseases)
Attending Physician, Division of Infectious Diseases, Children's Hospital of Philadelphia
Chief, Division of Infectious Diseases, Children's Hospital of Philadelphia
Attending physician, Hospital of the University of Pennsylvania
Professor, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Division of Infectious Diseases
10006 Colket Translational Research Building (CTRB)
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-2457
Fax: 314-286-2895
Lab: 215-590-2382
BS (Major Biology/minor Chemistry)
Duke University School of Medicine, 1996.
PhD (Biochemistry)
Duke University School of Medicine, 2002.
Duke University School of Medicine, 2003.
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Description of Clinical Expertise

Chief, Division of Infectious Diseases, Children's Hospital of Philadelphia

Description of Research Expertise

Dr. Odom John studies the malaria parasite, Plasmodium falciparum, to understand its basic molecular and cellular biology and functions of its specific metabolic pathways — what the parasite needs to make and why it needs to make it — to identify new antimalarial drug targets and develop new diagnostics.

Selected Publications

Schaber CL, Katta N, Bollinger LB, Mwale M, Mlotha-Mitole R, Trehan I, Raman B, Odom John AR: Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants. J Infect Dis 217(10): 1553-1560, Apr 2018.

Kelly M, Su CY, Schaber C, Crowley JR, Hsu FF, Carlson JR, Odom AR: Malaria parasites produce volatile mosquito attractants. mBio 6(2): pii: e00235-e00315, Mar 2015 Notes: Rated “exceptional,” Faculty of 1000; doi: 10.3410/f.725403920.793505527.

Guggisberg AM, Park J, Edwards RL, Kelly ML, Hodge DM, Tolia NH*, Odom AR*: A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. Nat Commun 5: 4467, July 2014 Notes: doi: 10.1038/ncomms5467 Rated “exceptional,” Faculty of 1000; doi: 10.3410/f.718505064.793497729.

Guggisberg AM, Frasse PM, Jezewski AJ, Kafai NM, Gandhi AY, Erlinger SJ, Odom John AR: Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites. mBio 9(6): e01193-18, Nov 2018.

Edwards, R. L., Heueck, I., Lee, S. G., Shah, I. T., Miller, J. J., Jezewski, A. J., Mikati, M. O., Wang, X., Brothers, R. C., Heidel, K. M., Osbourn, D. M., Burnham, C. D., Alvarez, S., Fritz, S. A., Dowd, C. S., Jez, J. M., Odom John, A. R.: Potent, specific MEPicides for treatment of zoonotic staphylococci. PLoS Pathog 16(6): e1007806, June 2020.

Guggisberg AM, Sayler KA, Wisely SM, Odom John AR: Natural History of Plasmodium odocoilei Malaria Infection in Farmed White-Tailed Deer. mSphere 3(2): e00067-18, Apr 2018.

Guggisberg AM, Sundararaman SA, Lanaspa M, Moraleda C, González R, Mayor A, Cisteró P, Hutchinson D, Kremsner PG, Hahn BH, Bassat Q, Odom AR: Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure with Fosmidomycin-Clindamycin. J Infect Dis 214(7): 1085-1091, Oct 2016.

Chiotos, Kathleen, Bassiri, Hamid, Behrens, Edward M, Blatz, Allison M, Chang, Joyce, Diorio, Caroline, Fitzgerald, Julie C, Topjian, Alexis, John, Audrey R Odom: Multisystem Inflammatory Syndrome in Children during the COVID-19 pandemic: a case series. Journal of the Pediatric Infectious Diseases Society 9(3): 393-398, Jul 2020.

Mikati, Marwa O., Miller, Justin J., Osbourn, Damon M., Ghebremichael, Naomi, Shah, Ishaan T., Burnham, Carey-Ann D., Heidel, Kenneth M., Yan, Victoria C., Muller, Florian L., Dowd, Cynthia S., Edwards, Rachel L., Odom John, Audrey R.: Antimicrobial prodrug activation by the staphylococcal glyoxalase GloB. ACS Infectious Diseases 6(11): 3064-3075, Nov 2020.

Mathews, Emily S., Jezewski, Andrew J., Odom John, Audrey R.: Protein prenylation and Hsp40 in thermotolerance of Plasmodium falciparum malaria parasites. mBio 12(3): e0076021, June 2021 Notes:

Miller, J. J., Shah, I. T., Hatten, J., Barekatain, Y, Mueller, E.A., Moustafa, A.M., Edwards, R. L., Dowd, C. S., Planet, P.J., Muller, F.L., Jez, J. M., Odom John, A. R.: Structure-guided microbial targeting of antistaphylococcal prodrugs. eLife 10: e66657, Jul 2021 Notes: Submitted to bioRxiv:

Elaina E., Elikplim H. Akaho, Anna Sobilo, Lisa Young, and Audrey R. Odom John: Concordance of preoperative testing with time of surgery testing for SARS-CoV-2 in pediatric surgical patients. Pediatrics 147(4): e2020044289, Apr 2021 Notes: 10.1542/peds.2020-044289.

Elaina E. Lin, Elikplim H. Akaho, Anna Sobilo, Allison M. Blatz, William R. Otto, Audrey R. Odom John: Concordance of Upper and Lower Respiratory Tract Samples for SARS-CoV-2 in Pediatric Patients: Implications for Perioperative Diagnosis and Infection Control. Anesthesiology 134(6): 970-972, Apr 2021.

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Last updated: 08/09/2023
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