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Aaron Felix Alexander-Bloch, MD, PhD, MPhil
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Assistant Professor of Psychiatry
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Attending Psychiatrist, Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia
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Attending Psychiatrist, Penn Psychosis Evaluation and Recovery Center Clinic
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Department: Psychiatry
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Graduate Group Affiliations
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Contact information
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Richards Biomedical Research Laboratories, B504
35 3700 Hamilton Walk
Philadelphia, PA 19104
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35 3700 Hamilton Walk
Philadelphia, PA 19104
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Publications
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Education:
21 7 AB 17 (Philosophy) c
28 Harvard College, 2006.
21 a MPhil 22 (Computational Biology) c
30 University of Cambridge, 2008.
21 8 PhD 19 (Neuroscience) c
30 University of Cambridge, 2013.
21 7 MD 15 (Medicine) c
40 David Geffen School of Medicine at UCLA, 2015.
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Permanent link21 7 AB 17 (Philosophy) c
28 Harvard College, 2006.
21 a MPhil 22 (Computational Biology) c
30 University of Cambridge, 2008.
21 8 PhD 19 (Neuroscience) c
30 University of Cambridge, 2013.
21 7 MD 15 (Medicine) c
40 David Geffen School of Medicine at UCLA, 2015.
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Description of Clinical Expertise
19 Psychosis71
Description of Research Expertise
345 Dr Alexander-Bloch investigates normal brain development and the altered developmental trajectories that lead to mental illness. As the Director of the Brain-Gene Development Lab, he leads a multi-disciplinary team that uses advanced computational approaches to analyze large-scale imaging, clinical, and genomics data. Their goal is to translate the highly polygenic risk for psychosis and other neurodevelopmental psychiatric disorders into pathophysiologic mechanisms, to inform therapeutic targets and improve risk assessment. Dr. Alexander-Bloch has a history of pioneering approaches that have become widely used by the broader field. His areas of expertise lie at the intersection of advanced multimodal MRI methods, neurotypical brain maturation, and rare and common genetic variants that confer psychiatric risk.e 29
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152 Fan XR, He Y, Wang YS, Li L; Lifespan Brain Chart Consortium (LBCC); China Autism Brain Imaging Consortium (CABIC); Duan X, Zuo XN.: Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia. Commun Biol 8: 1157, Aug 2025.
196 Sha Z, Warrier V, Bethlehem RAI, Schultz LM, Merikangas A, Sun KY, Gur RC, Gur RE, Shinohara RT, Seidlitz J, Almasy L, Andreassen OA, Alexander-Bloch AF*.: The overlapping genetic architecture of psychiatric disorders and cortical brain structure. Nature Mental Health Aug 2025 Notes: doi: 10.1038/s44220-025-00475-7, *senior author.
15b Sha Z, Sun KY, Jung B, Barzilay R, Moore TM, Almasy L, Forsyth JK, Prem S, Gandal MJ, Seidlitz J, Glessner JT, Alexander-Bloch AF.: Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study. Am J Psychiatry 182: 763-778, Aug 2025.
24e Sydnor VJ, Bagautdinova J, Larsen B, Arcaro MJ, Barch DM, Bassett DS, Alexander-Bloch AF, Cook PA, Covitz S, Franco AR, Gur RE, Gur RC, Mackey AP, Mehta K, Meisler SL, Milham MP, Moore TM, Müller EJ, Roalf DR, Salo T, Schubiner G, Seidlitz J, Shinohara RT, Shine JM, Yeh FC, Cieslak M, Satterthwaite TD.: Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity. Nat Neurosci 28(8): 1772-1786, August 2025 Notes: doi: 10.1038/s41593-025-01991-6. Epub 2025 Jul 4.
243 Dorfschmidt L, White S, Gardner M, Bedford S, Ball G, Edwards AD, Gu Y, He Y, Huang H, Karandikar S, Kyriakopoulou V, Ouyuang M, Pulli EP, Raznahan A, Robinson EC, Romero-García R, Satterthwaite TD, Schabdach J, Sebenius I, Sha Z, Shinohara RT, Tuulari J, Vaghi MM, Vogel J, Váša F, Williams L, Zimmerman D; Lifespan Brain Chart Consortium; Warrier V, Wagstyl K, Bullmore ET, Bethlehem RAI, Seidlitz J, Alexander-Bloch A.: Charting structural brain asymmetry across the human lifespan. bioRxiv Jul 2025.
17b Mandal AS, Shinohara RT, Jung B, Gardner M, Akouri HE, Yerys BE, Guthrie W, Janke KM, Herrington JD, Hocking MC, Ball G, Payne JM, North KN, Muhlert N, Garg S, Seidlitz J, Fisher MJ, Alexander-Bloch A.: NF1-specific growth charts for head circumference over the first three years of life. medRxiv Jun 2025.
17d Schabdach JM, Williams RMS, Logan J, Padmanabhan V, D'Aiello Iii R, Mclaughlin J, Gonzalez A, Krause EM, Tasian GE, Sotardi S, Alexander-Bloch A*.: From Scanner to Science: Reusing Clinically Acquired Medical Images for Research. AMIA Jt Summits Transl Sci Proc 2025: 471-480, Jun 2025 Notes: *senior author.
23b Keller AS, Sun KY, Francisco A, Robinson H, Beydler E, Bassett DS, Cieslak M, Cui Z, Davatzikos C, Fan Y, Gardner M, Kishton R, Kornfield SL, Larsen B, Li H, Linder I, Pines A, Pritschet L, Raznahan A, Roalf DR, Seidlitz J, Shafiei G, Shinohara RT, White LK, Wolf DH, Alexander-Bloch A, Satterthwaite TD, Shanmugan S.: Reproducible sex differences in personalised functional network topography in youth. Br J Psychiatry 226(6): 383-391, June 2025 Notes: doi: 10.1192/bjp.2025.135. Epub 2025 Jun 19.
1a1 Sun KY, Schmitt JE, Moore TM, Barzilay R, Almasy L, Schultz LM, Mackey AP, Kafadar E, Sha Z, Seidlitz J, Mallard TT, Cui Z, Li H, Fan Y, Fair DA, Satterthwaite TD, Keller AS, Alexander-Bloch A*: Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence. JAMA Psychiatry Jun 2025 Notes: *senior author.
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Selected Publications
1cd Sun KY, Schmitt JE, Moore TM, Barzilay R, Almasy L, Schultz LM, Mackey AP, Kafadar E, Sha Z, Seidlitz J, Mallard TT, Cui Z, Li H, Fan Y, Fair DA, Satterthwaite TD, Keller AS, Alexander-Bloch A.: Polygenic Risk Underlies Youth Psychopathology and Personalized Functional Brain Network Topography. JAMA Psychiatry 82(9): 905-915, September 2025 Notes: doi: 10.1001/jamapsychiatry.2025.1258.152 Fan XR, He Y, Wang YS, Li L; Lifespan Brain Chart Consortium (LBCC); China Autism Brain Imaging Consortium (CABIC); Duan X, Zuo XN.: Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia. Commun Biol 8: 1157, Aug 2025.
196 Sha Z, Warrier V, Bethlehem RAI, Schultz LM, Merikangas A, Sun KY, Gur RC, Gur RE, Shinohara RT, Seidlitz J, Almasy L, Andreassen OA, Alexander-Bloch AF*.: The overlapping genetic architecture of psychiatric disorders and cortical brain structure. Nature Mental Health Aug 2025 Notes: doi: 10.1038/s44220-025-00475-7, *senior author.
15b Sha Z, Sun KY, Jung B, Barzilay R, Moore TM, Almasy L, Forsyth JK, Prem S, Gandal MJ, Seidlitz J, Glessner JT, Alexander-Bloch AF.: Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study. Am J Psychiatry 182: 763-778, Aug 2025.
24e Sydnor VJ, Bagautdinova J, Larsen B, Arcaro MJ, Barch DM, Bassett DS, Alexander-Bloch AF, Cook PA, Covitz S, Franco AR, Gur RE, Gur RC, Mackey AP, Mehta K, Meisler SL, Milham MP, Moore TM, Müller EJ, Roalf DR, Salo T, Schubiner G, Seidlitz J, Shinohara RT, Shine JM, Yeh FC, Cieslak M, Satterthwaite TD.: Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity. Nat Neurosci 28(8): 1772-1786, August 2025 Notes: doi: 10.1038/s41593-025-01991-6. Epub 2025 Jul 4.
243 Dorfschmidt L, White S, Gardner M, Bedford S, Ball G, Edwards AD, Gu Y, He Y, Huang H, Karandikar S, Kyriakopoulou V, Ouyuang M, Pulli EP, Raznahan A, Robinson EC, Romero-García R, Satterthwaite TD, Schabdach J, Sebenius I, Sha Z, Shinohara RT, Tuulari J, Vaghi MM, Vogel J, Váša F, Williams L, Zimmerman D; Lifespan Brain Chart Consortium; Warrier V, Wagstyl K, Bullmore ET, Bethlehem RAI, Seidlitz J, Alexander-Bloch A.: Charting structural brain asymmetry across the human lifespan. bioRxiv Jul 2025.
17b Mandal AS, Shinohara RT, Jung B, Gardner M, Akouri HE, Yerys BE, Guthrie W, Janke KM, Herrington JD, Hocking MC, Ball G, Payne JM, North KN, Muhlert N, Garg S, Seidlitz J, Fisher MJ, Alexander-Bloch A.: NF1-specific growth charts for head circumference over the first three years of life. medRxiv Jun 2025.
17d Schabdach JM, Williams RMS, Logan J, Padmanabhan V, D'Aiello Iii R, Mclaughlin J, Gonzalez A, Krause EM, Tasian GE, Sotardi S, Alexander-Bloch A*.: From Scanner to Science: Reusing Clinically Acquired Medical Images for Research. AMIA Jt Summits Transl Sci Proc 2025: 471-480, Jun 2025 Notes: *senior author.
23b Keller AS, Sun KY, Francisco A, Robinson H, Beydler E, Bassett DS, Cieslak M, Cui Z, Davatzikos C, Fan Y, Gardner M, Kishton R, Kornfield SL, Larsen B, Li H, Linder I, Pines A, Pritschet L, Raznahan A, Roalf DR, Seidlitz J, Shafiei G, Shinohara RT, White LK, Wolf DH, Alexander-Bloch A, Satterthwaite TD, Shanmugan S.: Reproducible sex differences in personalised functional network topography in youth. Br J Psychiatry 226(6): 383-391, June 2025 Notes: doi: 10.1192/bjp.2025.135. Epub 2025 Jun 19.
1a1 Sun KY, Schmitt JE, Moore TM, Barzilay R, Almasy L, Schultz LM, Mackey AP, Kafadar E, Sha Z, Seidlitz J, Mallard TT, Cui Z, Li H, Fan Y, Fair DA, Satterthwaite TD, Keller AS, Alexander-Bloch A*: Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence. JAMA Psychiatry Jun 2025 Notes: *senior author.
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