Tristan Hayeck, PhD
Assistant Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
Abramson Research Bldg. 710B
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-7588
Education:
B.S. (Mechanical Engineering)
Massachusetts Institute of Technology, 2006.
M.S. (Biostatistics,)
Harvard T. H. Chan School of Public Health, 2012.
Ph.D. (Biostatistics)
Harvard T. H. Chan School of Public Health, 2015.
Permanent linkB.S. (Mechanical Engineering)
Massachusetts Institute of Technology, 2006.
M.S. (Biostatistics,)
Harvard T. H. Chan School of Public Health, 2012.
Ph.D. (Biostatistics)
Harvard T. H. Chan School of Public Health, 2015.
Selected Publications
Hayeck, T. J., Li, Y., Mosbruger, T. L., Bradfield, J. P., Gleason, A. G., Damianos, G., Shaw, G. T.-W., Duke, J. L., Conlin, J. L., Turner, T. N., Fernández-Viña, M. A., Sarmady, M., & Monos, D. S.: The Impact of Patterns in Linkage Disequilibrium and Sequencing Quality on the Imprint of Balancing Selection. Genome Biology and Evolution 1;16(2), Feb 2024 Notes: doi: 10.1093/gbe/evae009.Tristan Hayeck: Polygenic Risk Scores: Genomes to Risk Prediction. CLINICAL CHEMISTRY PODCAST. https://www.myadlm.org/science-and-research/clinical-chemistry/clinical-chemistry-podcasts/2023/polygenic-risk-scores_genomes-to-risk-prediction (eds.). June 2023.
Margolis DJ, Duke JL, Mitra N, Berna RA, Hoffstad OJ, Wasserman JR, Dinou A, Damianos G, Kotsopoulou I, Tairis N, Ferriola DA, Mosbruger TL, Hayeck TJ, Yan AC, Monos DS: A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with atopic dermatitis. Front Genet. 23(14), Jan 2023 Notes: 1004138. doi: 10.3389/fgene.2023.
Hayeck TJ, Busby GB, Chun Sung, Lewis ACF, Roberts MC, BJ Vilhjálmsson: Polygenic Risk Scores: Genomes to Risk Prediction. Clinical Chemistry 69(6): 551-557, 2023 Notes: https://doi.org/10.1093/clinchem/hvad049.
Hayeck, T.J., Stong, N., Baugh, E., Dhindsa, R., Turner, T.N., Malakar, A., Mosbruger, T.L., Duan, Y., Ionita-Laza, I., Goldstein, D. and Allen, A.S: Ancestry adjustment improves genome-wide estimates of regional intolerance. Genetics 221(2): iyac050, Apr 2022 Notes: doi: 10.1093/genetics/iyac050.
Shieh M, *Hayeck TJ, Dinh A, Duke JL, Chitnis N, Mosbruger T, Morlen RP, Ferriola D, Kneib C, Hu T, Huang Y, Monos DS : Complex Linkage Disequilibrium Effects in HLA-DPB1 Expression and Molecular Mismatch Analyses of Transplantation Outcomes. Transplantation 105(3): 637-647, March 2021.
Padhi EM, Hayeck TJ, Cheng Z, Chatterjee S, Mannion BJ, Byrska-Bishop M, Willems M, Pinson L, Redon S, Benech C, Uguen K, Audebert-Bellanger S, Le Marechal C, Férec C, Efthymiou S, Rahman F, Maqbool S, Maroofian R, Houlden H, Musunuri R, Narzisi G, Abhyankar A, Hunter RD, Akiyama J, Fries LE, Ng JK, Mehinovic E, Stong N, Allen AS, Dickel DE, Bernier RA, Gorkin DU, Pennacchio LA, Zody MC, Turner TN: Coding and noncoding variants in EBF3 are involved in HADDS and simplex autism. Hum Genomics 15(1): 44, 2021.
Hayeck, T. J., Stong, N., Wolock, C. J., Copeland, B., Kamalakaran, S., Goldstein, D.B., & Allen, A. S: Improved Pathogenic Variant Localization via a Hierarchical Model of Sub-regional Intolerance. The American Journal of Human Genetics 104(2): 299-309, Jan 2019.
Hayeck, T J., et al.: Mixed Model Association with Family-Biased Case-Control Ascertainment. The American Journal of Human Genetics 100(1): 31-39, Jan 2017.
Vilhjálmsson, B. J., Yang, J., Finucane, H. K., Gusev, A., Lindström, S., Ripke, S., Hayeck, T.J. Price, A. L.: Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. The American Journal of Human Genetics 97(4): 576-592, Oct 2015.