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Elizabeth M Margolskee, MD MPH
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Associate Professor of Clinical Pathology and Laboratory Medicine
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Hematopathologist, Hospital of the University of Pennsyvania
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Director of Hematology Laboratory, The Children's Hospital of Philadelphia
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Associate Chair, Workforce Resiliency, The Children's Hospital of Philadelphia
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Department: Pathology and Laboratory Medicine
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Contact information
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3401 Civic Center Boulevard
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Office: 6316808643
3c Lab: 2674265262
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Email:
margolskee@email.chop.edu
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margolskee@email.chop.edu
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Education:
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3a Harvard University, Cambridge, MA, 2006.
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45 Mount Sinai School of Medicine, New York, NY, 2010.
21 8 MPH 19 (Epidemiology) c
4c Columbia University Mailman School of Public Health, 2014.
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Permanent link21 7 AB c
3a Harvard University, Cambridge, MA, 2006.
21 7 MD c
45 Mount Sinai School of Medicine, New York, NY, 2010.
21 8 MPH 19 (Epidemiology) c
4c Columbia University Mailman School of Public Health, 2014.
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86 I am interested in quality and process improvement in the lab, and I am particularly fascinated by pediatric myeloid neoplasms.
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df I work closely with Surabhi Mulchandani, Vice Chair for Laboratory Administration, and other leadership in the department, to develop sustainable, ongoing strategies to develop and strengthen the pathology workforce.
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Description of Clinical Expertise
1d9 I am a hematopathologist and Director of the hematology laboratory at Children's Hospital of Philadelphia. I came to hematopathology originally because I wanted to care for critically ill patients alongside intelligent, curious clinicians in a collaborative fashion. I also enjoy interacting with our strong flow cytometrists, medical technologists, molecular pathologists, cytogeneticists, histotechs and pathology assistants, who make my work possible.8
86 I am interested in quality and process improvement in the lab, and I am particularly fascinated by pediatric myeloid neoplasms.
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Description of Other Expertise
142 On my first day as a lab director, I learned that our entire dayshift staff had been exposed to COVID-19 in the workplace and had to quarantine. Although no one became seriously ill, this experience framed my relationship with laboratory professionals, and highlighted their role as front line workers.8
df I work closely with Surabhi Mulchandani, Vice Chair for Laboratory Administration, and other leadership in the department, to develop sustainable, ongoing strategies to develop and strengthen the pathology workforce.
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12c Zheng DJ, Margolskee E, Borek RC, Devine KJ.: EBV-Negative CD20+ Plasma Cell Posttransplant Lymphoproliferative Disorder of the Airway following Liver Transplant in a 16-Month Old. Pediatr Blood Cancer 79(9): e31901, Sept 2025.
1d2 Li D, Tasian SK, Wertheim G, Rheingold SR, Bernt KM, Newman H, Wainwright L, Wilmoth DM, Thiel B, Surrey LF, Margolskee E, Pillai V, Luo M, Paessler ME, Hunger SP, Li MM, Zhong Y.: Integrated genomic analysis to reduce chromosomal analysis for the diagnosis of pediatric hematologic malignancies: addressing the shortage of cytogenetic technologists. Haematologica 110(8): 1861-1864, Aug 2025.
123 Caitlyn Musick, Grace McGrath, Megan McAuley, Elizabeth Margolskee: Enhanced Interprofessional Communication Between Nurses and Laboratory Scientists Reduces Specimen Cancellation Rate. CHOP Education Day January 2025.
133 Barry D, Margolskee E: Optimizing Reticulocyte Analysis in Anemic Patients: A 1:3 Dilution versus Manual Counting for Flag Resolution. Association for Diagnostics and Laboratory Medicine Annual Meeting 2025 Notes: Poster Presentation.
f3 Hamdan H, Liu Y, Wang SA, Bledsoe J, Chisholm KM, Siddon A, Ohgami R, George TI, Kurzer J, Hasserjian RP, Arber DA, Bagg A, Foucar K, Margolskee E, Laczko D, Chen W, Fuda F, Aggarwal N, Weinberg OK f9 : Clinical, Immunophenotypic, and Genomic Findings of Acute Myeloid Leukemia with RAM Immunophenotype: Comparison with Other CD56-positive Acute Leukemias. eJHaem December 2024 Notes: https://doi.org/10.1002/jha2.1052.
15a Chandan Kular, Kenneth Smith, Kara Thompson, Elizabeth Margolskee: Addressing patient safety and interprofessional communication through the implementation of a Challenging Interactions reporting tool in a clinical laboratory. CHOP Employee Well-being Summit November 2024.
14d Kim D, Margolskee E, Goyal A, Siddiqui MT, Heymann JJ, Rao R, Hayden J: Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays. J Clin Pathol November 2023 Notes: Online ahead of print.
104 Fenu EM, Margolskee E, Pillai V: Transdifferentiation of B-lymphoblastic Leukemia to Histiocytic Sarcoma After Immunotherapy. American Journal of Hematology 98(8): E216-E218, August 2023.
117 Dana Martin, Megan Zoltowski, Emily Williams, Elizabeth Margolskee: Optimizing ISLH lymphocytosis and monocytosis thresholds for manual differential smear review in the pediatric setting. IJLH 45: 76, 2023.
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Selected Publications
110 Lahiri A, Shukla S, Stear B, Ahooyi TM, Beigel K, Margolskee E, Taylor D.: Benchmarking Transformer Embedding Models for Biomedical Terminology Standardization. Mach Learn Appl 21: 100683, Sept 2025.12c Zheng DJ, Margolskee E, Borek RC, Devine KJ.: EBV-Negative CD20+ Plasma Cell Posttransplant Lymphoproliferative Disorder of the Airway following Liver Transplant in a 16-Month Old. Pediatr Blood Cancer 79(9): e31901, Sept 2025.
1d2 Li D, Tasian SK, Wertheim G, Rheingold SR, Bernt KM, Newman H, Wainwright L, Wilmoth DM, Thiel B, Surrey LF, Margolskee E, Pillai V, Luo M, Paessler ME, Hunger SP, Li MM, Zhong Y.: Integrated genomic analysis to reduce chromosomal analysis for the diagnosis of pediatric hematologic malignancies: addressing the shortage of cytogenetic technologists. Haematologica 110(8): 1861-1864, Aug 2025.
123 Caitlyn Musick, Grace McGrath, Megan McAuley, Elizabeth Margolskee: Enhanced Interprofessional Communication Between Nurses and Laboratory Scientists Reduces Specimen Cancellation Rate. CHOP Education Day January 2025.
133 Barry D, Margolskee E: Optimizing Reticulocyte Analysis in Anemic Patients: A 1:3 Dilution versus Manual Counting for Flag Resolution. Association for Diagnostics and Laboratory Medicine Annual Meeting 2025 Notes: Poster Presentation.
f3 Hamdan H, Liu Y, Wang SA, Bledsoe J, Chisholm KM, Siddon A, Ohgami R, George TI, Kurzer J, Hasserjian RP, Arber DA, Bagg A, Foucar K, Margolskee E, Laczko D, Chen W, Fuda F, Aggarwal N, Weinberg OK f9 : Clinical, Immunophenotypic, and Genomic Findings of Acute Myeloid Leukemia with RAM Immunophenotype: Comparison with Other CD56-positive Acute Leukemias. eJHaem December 2024 Notes: https://doi.org/10.1002/jha2.1052.
15a Chandan Kular, Kenneth Smith, Kara Thompson, Elizabeth Margolskee: Addressing patient safety and interprofessional communication through the implementation of a Challenging Interactions reporting tool in a clinical laboratory. CHOP Employee Well-being Summit November 2024.
14d Kim D, Margolskee E, Goyal A, Siddiqui MT, Heymann JJ, Rao R, Hayden J: Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays. J Clin Pathol November 2023 Notes: Online ahead of print.
104 Fenu EM, Margolskee E, Pillai V: Transdifferentiation of B-lymphoblastic Leukemia to Histiocytic Sarcoma After Immunotherapy. American Journal of Hematology 98(8): E216-E218, August 2023.
117 Dana Martin, Megan Zoltowski, Emily Williams, Elizabeth Margolskee: Optimizing ISLH lymphocytosis and monocytosis thresholds for manual differential smear review in the pediatric setting. IJLH 45: 76, 2023.
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