George M Burslem

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Assistant Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics

Contact information
151 Bradley Street
New Haven, CT 06511
Education:
MSci (Chemistry with Industrial Experience)
University of Bristol , 2011.
PhD (An Integrated Approach to the Discovery of Inhibitors of Protein-Protein Interactions)
University of Leeds, 2015.
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Selected Publications

Hellerschmied Doris, Serebrenik Yevgeniy V, Shao Lin, Burslem George M, Crews Craig M: Protein folding state-dependent sorting at the Golgi apparatus. Molecular biology of the cell 30(17): 2296-2308, Aug 2019.

Burslem George M, Schultz Anna Reister, Bondeson Daniel P, Eide Christopher A, Savage Stevens Samantha L, Druker Brian J, Crews Craig M: Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer research Jul 2019.

Burslem George M, Song Jayoung, Chen Xin, Hines John, Crews Craig M: Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. Journal of the American Chemical Society 140(48): 16428-16432, Dec 2018.

Burslem George M, Kyle Hannah F, Nelson Adam, Edwards Thomas A, Wilson Andrew J: Correction: Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chemical science 9(7): 2010-2011, 02 2018.

Burslem George M, Kyle Hannah F, Nelson Adam, Edwards Thomas A, Wilson Andrew J: Erratum: Further Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chemical science 9(7): 2008-2009, 02 2018.

Burslem George M, Ottis Philipp, Jaime-Figueroa Saul, Morgan Alicia, Cromm Philipp M, Toure Momar, Crews Craig M: Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure-Degradation Relationships. ChemMedChem 13(15): 1508-1512, 08 2018.

Bondeson Daniel P, Smith Blake E, Burslem George M, Buhimschi Alexandru D, Hines John, Jaime-Figueroa Saul, Wang Jing, Hamman Brian D, Ishchenko Alexey, Crews Craig M: Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead. Cell chemical biology 25(1): 78-87.e5, 01 2018.

Burslem George M, Smith Blake E, Lai Ashton C, Jaime-Figueroa Saul, McQuaid Daniel C, Bondeson Daniel P, Toure Momar, Dong Hanqing, Qian Yimin, Wang Jing, Crew Andrew P, Hines John, Crews Craig M: The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell chemical biology 25(1): 67-77.e3, 01 2018.

Burslem George M, Crews Craig M: Small-Molecule Modulation of Protein Homeostasis. Chemical reviews 117(17): 11269-11301, Sep 2017.

Grison Claire M, Burslem George M, Miles Jennifer A, Pilsl Ludwig K A, Yeo David J, Imani Zeynab, Warriner Stuart L, Webb Michael E, Wilson Andrew J: Double quick, double click reversible peptide "stapling". Chemical science 8(7): 5166-5171, Jul 2017.

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Last updated: 01/07/2020
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