Jing Wang, MD, FACMG, ASCP (MB)

faculty photo
Associate Professor of Clinical Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
ARC Suite 716A
3615 Civic Center Blvd
Philadelphia, PA 19104-4318
Office: 2676933441
Lab: 12155900392
Sun Yat-sen University of Medical Sciences, China, 1986.
M.Sc. (Medical Genetics)
Sun Yat-sen University of Medical Sciences, China, 1989.
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Description of Clinical Expertise

The main role of my clinical service is to provide integrated genomic testing to clinicians. I am particularly interested in neurodevelopmental disorders and mitochondrial disorders. We have developed using single long-range PCR followed by NGS for mitochondrial genome analysis, which can simultaneously detect mtDNA point mutations, small indels, provide accurate heteroplasmy level. It is also a highly sensitive assay to detect mtDNA large deletion and multiple deletions. This assay has been widely adapted by clinical diagnostic laboratories and become a new gold standard for mtDNA analysis.

Selected Publications

Wong LC, Chen T, Schmitt ES, Wang J, Tang S, Landsverk M, Li F, Wang Y, Zhang S, Zhang VW, Craigen WJ. : Clinical and laboratory interpretation of mitochondrial mRNA Hum Mutat July 2020.

Wong LC, Chen T, Wang J, Tang S, Schmitt ES, Landsverk M, Li F, Wang Y, Zhang S, Zhang VW, Craigen WJ.: Interpretation of mitochondrial tRNA variants. Genet Med January 2020.

Kartvelishvili, E., Tworowski, D., Vernon, H., Moor, N., Wang, J., Wong, L.J., Chrzanowska-Lightowlers, Z., Safro, M. : Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci. 26(8): 1505-1516, Aug 2017.

Tsai, A.C.H., Hung, Y.W., Harding, C., Koeller, D.M., Wang J., Wong, L.J.C. : Next generation deep sequencing corrects diagnostic pitfalls of traditional molecular approach in a patient with prenatal onset of Pompe disease. American Journal of Medical Genetics, Part A 173(9): 2500-2504, 2017.

Dai, H., Zhang, V. W., El-Hattab, A. W., Ficicioglu, C., Shinawi, M., Lines, M., Schulze, A., McNutt, M., Gotway, G., Tian, X., Chen, S., Wang, J., Craigen, W. J., Wong, L. J.: FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome. Clin Genet. 91(4): 634-639. doi: 10.1111/cge.12894. Epub 2017 Jan 5. 2017.

Li, J., Tang, J., Feng, Y., Xu, M., Chen, R., Zou, X., Sui, R., Chang, E.Y., Lewis, R.A., Zhang, V.W., Wang, J., Wong, L.C.: Improved Diagnosis of Inherited Retinal Dystrophies by High-Fidelity PCR of ORF15 followed by Next-Generation Sequencing. J Mol Diagn. 18(6): 817-824. . Nov; Epub 2016 Sep 10. 2016 Notes: doi: 10.1016/j.jmoldx.2016.06.007.

Wang, X., Feng, Y., Li, J., Zhang, W., Wang, J., Lewis, R.A., Wong, L.J.: Retinal Diseases Caused by Mutations in Genes Not Specifically Associated with the Clinical Diagnosis. PLoS One. 11(10): e0165405. Oct 27 2016 Notes: doi: 10.1371/journal.pone.0165405. eCollection 2016.

Yu, H., Zhang, V.W., Stray-Pedersen, A., Hanson, I.C., Forbes, L.R., de la Morena, M.T., Chinn, I.K., Gorman, E., Mendelsohn, N.J., Pozos, T., Wiszniewski, W., Nicholas, S.K., Yates, A.B., Moore, L.E., Berge, K.E., Sorte, H., Bayer, D.K., ALZahrani, D., Geha, R.S., Feng, Y., Wang, G., Orange, J.S., Lupski, J.R., Wang, J., Wong, L.J.: Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing. J Allergy Clin Immunol. 138(4): 1142-1151.e2. Oct 2016 Notes: doi: 10.1016/j.jaci.2016.05.035. Epub 2016 Jul 12.

Wang, J., Yu, H., Zhang, V. W., Tian, X., Feng, Y., Wang, G., Gorman, E., Wang, H., Lutz, R. E., Schmitt, E. S., Peacock, S., Wong, L. J.: Capture-based high-coverage NGS: a powerful tool to uncover a wide spectrum of mutation types. Genet Med. 18(5): 513-21. doi: 10.1038/gim.2015.121. Epub 2015 Sep 24. 2016.

Xu, M., Eblimit, A., Wang, J., Li, J., Wang, F., Zhao, L., Wang, X., Xiao, N., Li, Y., Wong, L. J., Lewis, R. A., Chen, R.: ADIPOR1 Is Mutated in Syndromic Retinitis Pigmentosa. Hum Mutat. 37(3): 246-9. doi: 10.1002/humu.22940. Epub 2016 Jan 6. 2016.

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Last updated: 03/24/2021
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