Wan-Ping Lee, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Associate Director, Penn Neurodegeneration Genomics Center (PNGC)
Department: Pathology and Laboratory Medicine
Contact information
D103, Richards Medical Research Laboratories
3700 Hamilton Walk
Philadelphia, PA 19104
3700 Hamilton Walk
Philadelphia, PA 19104
Education
B.B.A. (Management Information System)
Chung Yuan Christian University, 2001.
M.S. (Computer Science and Engineering)
National Sun Yat-Sen University, 2004.
Ph.D. (Electrical Engineering)
National Taiwan University, 2009.
Permanent linkB.B.A. (Management Information System)
Chung Yuan Christian University, 2001.
M.S. (Computer Science and Engineering)
National Sun Yat-Sen University, 2004.
Ph.D. (Electrical Engineering)
National Taiwan University, 2009.
Description of Research Expertise
My group focuses on discovering human genomic variations, especially structural variations such as copy number variations (deletions and duplications), insertions, tandem duplications, inversions, and translocations. They are substantial contributors to genetic diversity and are usually associated with human diseases. We are closely working on the Alzheimer’s Disease genomics data analysis and participating in the Alzheimer’s Disease Sequencing Project (ADSP) and Alzheimer’s Disease Genetics Consortium (ADGC).Selected Publications
EADB, EADI, Bonn, ADGC, CHARGE, FinnGen, GERAD, GR@ACE/DEGESCO & PGC-ALZ: Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias. Nature Genetics June 2026.Brenna Cholerton, Dana Godrich, Jeremy Pasteris, Joe Rivero, Eden R Martin, Brian W Kunkle, Adam C Naj, Kara L Hamilton-Nelson, Hui Wang, Wan-Ping Lee, Logan Dumitrescu, Timothy J Hohman, Richard Mayeux, Eric B Larson, Paul K Crane, C Dirk Keene, Caitlin S Latimer, Shubhabrata Mukherjee, Julia K Kofler, M Ilyas Kamboh, David A Bennett, Laura Molina-Porcel, Michael Cuccaro, Margaret A Pericak-Vance, Tatjana Rundek, William K Scott, Walter Kukull, Gerard Schellenberg, Alzheimer’s Disease Genetics Consortium, Gary W Beecham, Thomas J Montine: Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer’s disease and related dementias in a multi-site autopsy cohort. PLoS genetics 22, June 2026.
Amanda Kuzma, Otto Valladares, Emily Greenfest-Allen, Laura Cantwell, Zivadin Katanic, Maureen Kirsch, Heather Nicaretta, Youli Ren, Heather White, Andrew Wilk, Pavel Kuksa, Wan-Ping Lee, Yuk Yee Leung, Gerard D. Schellenberg & Li-San Wang: Genomic stewardship in Alzheimer’s disease: a decade of insights from the NIAGADS platform. npj Dementia March 2026.
Yumi Jin, Hui Wang, Adam C. Naj, Li-San Wang, Wan-Ping Lee: GrafAnc: Reliable and Reproducible Inference of Continental and Regional Population Structure. Human Genetics and Genomics (HGG) Advances 7(1), January 2026.
Dana Godrich, Jeremy Pasteris, Eden R. Martin, Brian Kunkle, Adam C. Naj, Kara Hamilton, Hui Wang, Wan-Ping Lee, Logan Dumitrescu, Timothy J. Hohman, Richard Mayeux, Eric B. Larson, Paul K. Crane, C. Dirk Keene, Caitlin Latimer, Shubhabrata Mukherjee, Julia Kofler, M. Ilyas Kamboh, David A. Bennett, Laura Molina-Porcel, Gerard Schellenberg, Margaret A. Pericak-Vance, Michael Cuccaro, William K. Scott, Tatjana Rundek, Walter Kukull, Thomas Montine, Gary W. Beecham, the Alzheimer's Disease Genetics Consortium (ADGC): TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B. Alzheimer's & Dementia 21(11), November 2025.
Vaishnavi Venkat, Kaylyn Clark, X. Jessie Jeng, Tsung-Chieh Yao, Hui-Ju Tsai, Tzu-Pin Lu, Tzu-Hung Hsiao, Ching-Heng Lin, Shannon Holloway, Cathrine Hoyo, Shin-Yi Chou, Hui Wang, Wan-Ping Lee, Li-San Wang, Jung-Ying Tzeng: Exploring Random Forest in Genetic Risk Score Construction. Genetic Epidemiology 49(8), October 2025.
Po-Liang Cheng, Hui Wang, Beth A. Dombroski, John J. Farrell, Iris Horng, Tingting Chung, Giuseppe Tosto, Brian W. Kunkle, William S.Bush, Badri Vardarajan, Gerard D. Schellenberg, Wan-Ping Lee: A specialized reference panel with structural variants integration for improving genotype imputation in Alzheimer disease and related dementias. Human Genetics and Genomics Advances 6(4), August 2025.
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L. Hamilton-Nelson, Nicholas R. Wheeler, Yi Zhao, John J. Farrell, Michelle A. Grunin, Yuk Yee Leung, Pavel P. Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse B. Mez, Ellen L. Palmer, Jagan Pillai, Richard M. Sherva, Yeunjoo E. Song, Xiaoling Zhang, Takeshi Ikeuchi, Taha Iqbal, Omkar Pathak, Otto Valladares, Dolly Reyes-Dumeyer, Amanda B. Kuzma, Erin Abner, Larry D. Adams, Perrie M. Adams, Alyssa Aguirre, Marilyn S. Albert, Roger L. Albin, Mariet Allen, Lisa Alvarez, Liana G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig S. Atwood, Sanford Auerbach, Gayle Ayres, Clinton T. Baldwin, Robert C. Barber, Lisa L. Barnes, Sandra Barral, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, Bruno A. Benitez, David Bennett, John Bertelson, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James Brewer, James R. Burke, Jeffrey M. Burns, Joseph D. Buxbaum, Nigel J. Cairns, Laura B. Cantwell, Chuanhai Cao, Christopher S. Carlson, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A. Chin, Helena C. Chui, Jaeyoon Chung, Suzanne Craft, Paul K. Crane, David H. Cribbs, Elizabeth A. Crocco, Carlos Cruchaga, Michael L. Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L. De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W. Dickson, Beth A. Dombroski, Rachelle S. Doody, Ranjan Duara, NIlüfer Ertekin-Taner, Denis A. Evans, Kelley M. Faber, Thomas J. Fairchild, Kenneth B. Fallon, David W. Fardo, Martin R. Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Robert P. Friedland, Tatiana M. Foroud, Matthew P. Frosch, Brian Fulton-Howard, Douglas R. Galasko, Adriana Gamboa, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Rodney C.P. Go, Alison M. Goate, Thomas J. Grabowski, Neill R. Graff-Radford, Robert C. Green, John H. Growdon, Hakon Hakonarson, James Hall, Ronald L. Hamilton, Oscar Harari, John Hardy, Lindy E. Harrell, Elizabeth Head, Victor W. Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S. Honig, Ryan M. Huebinger, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Linda S. Hynan, Laura Ibanez, Gail P. Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M. Ilyas Kamboh, Anna M. Karydas, Mindy J. Katz, John S. Kauwe, Jeffrey A. Kaye, C. Dirk Keene, Aisha Khaleeq, Masataka Kikuchi, Ronald Kim, Janice Knebl, Neil W. Kowall, Joel H. Kramer, Walter A. Kukull, Frank M. LaFerla, James J. Lah, Eric B. Larson, Alan Lerner, James B. Leverenz, Allan I. Levey, Andrew P. Lieberman, Richard B. Lipton, Mark Logue, Oscar L. Lopez, Kathryn L. Lunetta, Constantine G. Lyketsos, Douglas Mains, Flanagan E. Margaret, Daniel C. Marson, Eden RR. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C. McCormick, Susan M. McCurry, Andrew N. McDavid, Stefan McDonough, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, Edwin S. Monuki, John C. Morris, Shubhabrata Mukherjee, Amanda J. Myers, Trung Nguyen, Thomas Obisesan, Sid O’Bryant, John M. Olichney, Marcia Ory, Raymond Palmer, Joseph E. Parisi, Henry L. Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C. Petersen, Helen Petrovitch, Aimee Pierce, Marsha Polk, Wayne W. Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F. Quinn, Ashok Raj, Murray Raskind, Eric M. Reiman, Barry Reisberg, Joan S. Reisch, John M. Ringman, Erik D. Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J. Rosen, Roger N. Rosenberg, Donald R. Royall, Marwan Sabbagh, A. Dessa Sadovnick, Mark A. Sager, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Susan H. Slifer, Scott Small, Amanda G. Smith, Janet P. Smith, Joshua A. Sonnen, Salvatore Spina, Peter St George-Hyslop, Takiyah D. Starks, Robert A. Stern, Alan B. Stevens, Stephen M. Strittmatter, David Sultzer, Russell H. Swerdlow, Rudolph E. Tanzi, Jeffrey L. Tilson, John Q. Trojanowski, Juan C. Troncoso, Magda Tsolaki, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. van Eldik, Jeffery M. Vance, Badri N. Vardarajan, Robert Vassar, Harry V. Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Patrice L. Whitehead, Ellen M. Wijsman, Kirk C. Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S. Wingo, Thomas Wisniewski, Randall L. Woltjer, Martin Woon, Clinton B. Wright, Chuang-Kuo Wu, Steven G. Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W. Kunkle, William S. Bush, Akinori Miyashita, Goldie S. Byrd, Li-San Wang, Lindsay A. Farrer, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Gyungah R. Jun, Christiane Reitz & Adam C. Naj on behalf of Alzheimer’s Disease Genetics Consortium (ADGC): Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease. Genome Biology 26(210), July 2025.
Amanda Kuzma, Otto Valladares, Emily Greenfest-Allen, Heather Nicaretta, Maureen Kirsch, Youli Ren, Zivadin Katanic, Heather White, Andrew Wilk, Lauren Bass, Jascha Brettschneider, Luke Carter, Jeffrey Cifello, Wei-Hsuan Chuang, Kaylyn Clark, Prabhakaran Gangadharan, Jacob Haut, Pei-Chuan Ho, Wenhwai Horng, Taha Iqbal, Yumi Jin, Peter Keskinen, Alexis Lerro Rose, Michelle K. Moon, Joseph Manuel, Liming Qu, Flawless Robbins, Naveensri Saravanan, Jin Sha, Sam Tate, Yi Zhao, Alzheimer's Disease Sequencing Project, Laura Cantwell, Jake Gardner, Shin-Yi Chou, Jung-Ying Tzeng, William Bush, Adam Naj, Pavel Kuksa, Wan-Ping Lee, Yuk Yee Leung, Gerard Schellenberg, Li-San Wang: NIAGADS: A data repository for Alzheimer's disease and related dementia genomics. Alzheimers' & Dementia 21(6), June 2025.
Hui Wang, Beth A. Dombroski, Po-Liang Cheng, Albert Tucci, Ya-Qin Si, John J. Farrell, Jung-Ying Tzeng, Yuk Yee Leung, John S. Malamon, The Alzheimer's Disease Sequencing Project, Li-San Wang, Badri N. Vardarajan, Lindsay A. Farrer, Gerard D. Schellenberg, Wan-Ping Lee: Structural variation detection and association analysis of whole-genome-sequence data from 16,543 Alzheimer's disease sequencing project subjects. Alzheimer's & Dementia 21(6), June 2025.