Wan-Ping Lee, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
D103, Richards Medical Research Laboratories
3700 Hamilton Walk
Philadelphia, PA 19104
3700 Hamilton Walk
Philadelphia, PA 19104
Education:
B.B.A. (Management Information System)
Chung Yuan Christian University, 2001.
M.S. (Computer Science and Engineering)
National Sun Yat-Sen University, 2004.
Ph.D. (Electrical Engineering)
National Taiwan University, 2009.
Permanent linkB.B.A. (Management Information System)
Chung Yuan Christian University, 2001.
M.S. (Computer Science and Engineering)
National Sun Yat-Sen University, 2004.
Ph.D. (Electrical Engineering)
National Taiwan University, 2009.
Description of Research Expertise
My group focuses on discovering human genomic variations, especially structural variations such as copy number variations (deletions and duplications), insertions, tandem duplications, inversions, and translocations. They are substantial contributors to genetic diversity and are usually associated with human diseases. We are closely working on the Alzheimer’s Disease genomics data analysis and participating in the Alzheimer’s Disease Sequencing Project (ADSP) and Alzheimer’s Disease Genetics Consortium (ADGC).Selected Publications
Michael H Guo, Wan-Ping Lee, Badri Vardarajan, Gerard D Schellenberg, Jennifer Phillips-Cremins: Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer’s disease. Nature Communications 16(1126), January 2025.Hui Wang, Timothy S Change, Beth A Dombroski, Po-Liang Cheng, Ya-Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente-Banuet, Chong Li, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C Van Swieten, Elise Dopper, Bernardino F Ghetti, Kathy L Newell, Claire Troakes, Justo G de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G Beach, Geidy E Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A Ross, Douglas Galasko, Adam L Boxer, Bruce L Miller, Willian W Seeley, Vivianna M Van Deerlin, Edward B Lee, Charles L White III, Huw R Morris, Rohan de Silva, John F Crary, Alison M Goate, Jeffrey S Friedman, Yaroslau Compta, Yuk Yee Leung, Giovanni Coppola, Adam C Naj, Li-San Wang, PSP genetics study group, Clifton Dalgard, Dennis W Dickson, Günter U Höglinger, Jung-Ying Tzeng, Daniel H Geschwind, Gerard D Schellenberg, Wan-Ping Lee: Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells. Movement Disorders 2025 Notes: In Press.
Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, Po-Liang Cheng, Beth A Dombroski, Achilleas N Pitsillides, Nancy L Heard-Costa, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Adam Naj, Elizabeth E Blue11, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle1, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, The Alzheimer’s Disease Sequencing Project, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso: Association of Common and Rare Variants with Alzheimer’s Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer’s Disease Sequencing Project. Alzheimer's & dementia 20, October 2024 Notes: no issue.
Kurt Farrell, Jack Humphrey, Timothy Chang, Yi Zhao, Yuk Yee Leung, Pavel P. Kuksa, Vishakha Patil, Wan-Ping Lee, Amanda B. Kuzma, Otto Valladares, Laura B. Cantwell, Hui Wang, Ashvin Ravi, Claudia De Sanctis, Natalia Han, Thomas D. Christie, Robina Afzal, Shrishtee Kandoi, Kristen Whitney, Margaret M. Krassner, Hadley Ressler, SoongHo Kim, Diana Dangoor, Megan A. Iida, Alicia Casella, Ruth H. Walker, Melissa J. Nirenberg, Alan E. Renton, Bergan Babrowicz, Giovanni Coppola, Towfique Raj, Günter U. Höglinger, Ulrich Müller, Lawrence I. Golbe, Huw R. Morris, John Hardy, Tamas Revesz, Tom T. Warner, Zane Jaunmuktane, Kin Y. Mok, Rosa Rademakers, Dennis W. Dickson, Owen A. Ross, Li-San Wang, Alison Goate, Gerard Schellenberg, Daniel H. Geschwind, PSP Genetics Study Group, John F. Crary, Adam Naj: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nature Communications 15(7880), September 2024.
Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivanna M. Van Deerlin, Edward B. Lee, Charles L. White III, Huw Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li-San Wang, P. S. P. genetics study group, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Gerard D. Schellenberg, Daniel H. Geschwind, Wan-Ping Lee: Whole genome sequencing analysis reveals new susceptibility loci and structural variants associated with Progressive Supranuclear Palsy. Molecular Neurodegeneration 19(61), August 2024.
Nicholas R. Ray, Brian W. Kunkle, Kara Hamilton-Nelson, Jiji T. Kurup, Farid Rajabli, Min Qiao, Badri N. Vardarajan, Mehmet I. Cosacak, Caghan Kizil, Melissa Jean-Francois, Michael Cuccaro, Dolly Reyes-Dumeyer, Laura Cantwell, Amanda Kuzma, Jeffery M. Vance, Sujuan Gao, Hugh C. Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Rufus O. Akinyemi, Alzheimer's Disease Genetics Consortium, Wan-Ping Lee, Eden R. Martin, Li-San Wang, Gary W. Beecham, William S. Bush, Wanying Xu, Fulai Jin, Liyong Wang, Lindsay A. Farrer, Jonathan L. Haines, Goldie S. Byrd, Gerard D. Schellenberg, Richard Mayeux, Margaret A. Pericak-Vance, Christiane Reitz: Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry. Alzheimer's & Dementia 20(8), July 2024.
John S Malamon, John J Farrell, Li Charlie Xia, Beth A Dombroski, Rueben G Das, Jessica Way, Amanda B Kuzma, Otto Valladares, Yuk Yee Leung, Allison J Scanlon, Irving Antonio Barrera Lopez, Jack Brehony, Kim C Worley, Nancy R Zhang, Li-San Wang, Lindsay A Farrer, Gerard D Schellenberg, Wan-Ping Lee, Badri N Vardarajan: A comparative study of structural variant calling in WGS from Alzheimer's disease families. Life Science Alliance 7(5), February 2024 Notes: Co-corresponding author.
Yuk Yee Leung, Adam C. Naj, Yi-Fan Chou, Otto Valladares, Michael Schmidt, Kara Hamilton-Nelson, Nicholas Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Kaylyn Clark, Amanda B. Kuzma, Wan-Ping Lee, Laura Cantwell, Heather Nicaretta, Alzheimer’s Disease Sequencing Project, Jonathan Haines, Lindsay Farrer, Sudha Seshadri, Zoran Brkanac, Carlos Cruchaga, Margaret Pericak-Vance, Richard P. Mayeux, William S. Bush, Anita Destefano, Eden Martin, Gerard D. Schellenberg, Li-San Wang: Human whole-exome genotype data for Alzheimer's disease. Nature Communications 15(684), January 2024.
Jinfeng Lu, Camilo Toro, David R. Adams, Undiagnosed Diseases Network, Cristiane Araujo Martins Moreno, Wan-Ping Lee, Yuk Yee Leung, Mathew B. Harms, Badri Vardarajan, Erin L. Heinzen: LUSTR: a new customizable tool for calling genome-wide germline and somatic short tandem repeat variants. BMC Genomics 25(115), January 2024.
Pei-Chuan Ho, Wai Haung Yu, Boon Lead Tee, Wan-Ping Lee, Clara Li, Yian Gu, Jennifer S. Yokoyama, Dolly Reyes-Dumeyer, Yun-Beom Choi, Hyun-Sik Yang, Badri N. Vardarajan, Marian Tzuang, Kevin Lieu, Anna Lu, Kelley M. Faber, Zoë D. Potter, Carolyn Revta, Maureen Kirsch, Jake McCallum, Diana Mei, Briana Booth, Laura B. Cantwell, Fangcong Chen, Sephera Chou, Dewi Clark, Michelle Deng, Ting Hei Hong, Ling-Jen Hwang, Lilly Jiang, Yoonmee Joo, Younhee Kang, Ellen S. Kim, Hoowon Kim, Kyungmin Kim, Amanda B. Kuzma, Eleanor Lam, Serggio C. Lanata, Kunho Lee, Donghe Li, Mingyao Li, Xiang Li, Chia-Lun Liu, Collin Liu, Linghsi Liu, Jody-Lynn Lupo, Khai Nguyen, Shannon E. Pfleuger, James Qian, Winnie Qian, Veronica Ramirez, Kristen A. Russ, Eun Hyun Seo, Yeunjoo E. Song, Maria Carmela Tartaglia, Lu Tian, Mina Torres, Namkhue Vo, Ellen C. Wong, Yuan Xie, Eugene B. Yau, Isabelle Yi, Victoria Yu, Xiaoyi Zeng, Peter St George-Hyslop, Rhoda Au, Gerard D. Schellenberg, Jeffrey L. Dage, Rohit Varma, Ging-Yuek R. Hsiung, Howard Rosen, Victor W. Henderson, Tatiana Foroud, Walter A. Kukull, Guerry M. Peavy, Haeok Lee, Howard H. Feldman, Richard Mayeux, Helena Chui, Gyungah R. Jun, Van M. Ta Park, Tiffany W. Chow, Li-San Wang: Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians. Alzheimer's & Dementia 20(3), January 2024.