Sharon Ann McGrath-Morrow, M.B.A., M.D.

Professor of Pediatrics (Pulmonary Medicine)
Professor of Pediatrics, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Division of Pulmonary and Sleep Medicine
Children's Hospital of Philadelphia
Abramson Research Building
4th Floor, Suite 416H
3615 Civic Center Blvd.
Philadelphia, PA 19104
Children's Hospital of Philadelphia
Abramson Research Building
4th Floor, Suite 416H
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-3749
Fax: 267-425-0681
Fax: 267-425-0681
Email:
mcgrathmos@chop.edu
mcgrathmos@chop.edu
Publications
Links
Search PubMed for articles
NORD- rare disease database. Helped to review and edit site on Ataxia telangiectasia
Search PubMed for articles
NORD- rare disease database. Helped to review and edit site on Ataxia telangiectasia
Education:
BA (Biology with Distinction)
University of Virginia, 1981.
MD (Medicine)
University of Virginia, 1985.
M.B.A. (Business)
The Johns Hopkins University, 2009.
Permanent linkBA (Biology with Distinction)
University of Virginia, 1981.
MD (Medicine)
University of Virginia, 1985.
M.B.A. (Business)
The Johns Hopkins University, 2009.
Description of Clinical Expertise
I have expertise in the care of children with Ataxia telangiectasia and formerly preterm children with chronic lung disease and asthma.Description of Research Expertise
I have a long-standing interest in understanding how early-life lung injury adversely impacts lung health outcomes in later life. As a primary investigator of a translational laboratory, we have used in vivo and in vitro modeling to understand how lung injuries during early-life impact short and long-term respiratory outcomes. Current studies indicate that bacterial pneumonia/lower respiratory tract infections (LRTIs) are a major cause of morbidity and mortality in children < 5 years of age and epidemiological studies report direct links between early-life pneumonia and impaired lung function in adult life. We have extensive expertise in modeling bacterial pneumonia in neonates and juveniles and seek to understand the interactions between age-specific immune responses and lung epithelial recovery. Additionally, we are studying how early-life insults can cause aberrant mesenchymal growth predisposing the lung to chronic obstructive pulmonary disease in later life.As clinical correlates to my laboratory work, I also investigate the links between early life determinants and respiratory health outcomes in formerly preterm children with chronic lung disease. I am the director of the Children’s Hospital of Philadelphia (CHOP), outpatient BPD program, on the executive committee of the BPD collaborative and co- Chair of the BPD Collaborative outpatient committee.
I started a CHOP BPD outpatient registry in 2020 which currently has 750 participants who are followed longitudinally.
I am particularly interested in identifying modifiers that occur in the outpatient setting that influence respiratory outcomes in later life and may predispose to chronic obstructive lung disease in adult life.
Selected Publications
Jelte Kelchtermans, Joseph M. Collaco, Huiqi Qu, Frank Mentch, Sharon A. McGrath-Morrow, Hakon Hakonarson: Sex-Specific Spirometry Effects of Adult COPD Polygenic Score in Children with asthma. Scientific Reports March 2025.McGlynn JR, Martin A, Aoyama BC, McGrath-Morrow SA*, Collaco JM * corresponding author: Outpatient Diuretic Use and Respiratory Outcomes in Children with Bronchopulmonary Dysplasia During the First Three Years of Life. J Pediatr March 2025.
Leon C, Kawatra P, Martin A, Aoyama B, Collaco JM, McGrath-Morrow SA: Outpatient Respiratory Outcomes in Extremely Preterm Children during the first three years of life. Pediatric Pulmonology March 2025.
Magnarelli A, Liu Q, Wang F, Peng X, Wright J, Oak N, Natale V, Rothblum-Oviatt C, Lefton-Greif MA, McGrath-Morrow S, Crawford TO, Ehrhardt MJ, Lederman HM, Sharma R.: Prevalence and outcomes of cancer and treatment-associated toxicities for patients with Ataxia Telangiectasia. J Allergy Clin Immunol. February 2025.
Moore PE, Hayden LP, Villafranco NM, Toprak D, Rice JL, Rhein LM, Popova AP, McKinney RL, Manimtim WM, Levin JC, Lai KV, Gage SC, Bansal M, Baker CD, Austin ED, Agarwal A, McGrath-Morrow SA, Collaco JM. : Outpatient clinical care for bronchopulmonary dysplasia: A survey of the BPD collaborative. Pediatr Pulmonol. January 2025.
Akangire GG, Manimtim W, Agarwal A, Alexiou S, Aoyama BC, Austin ED, Bansal M, Fierro JL, Hayden LP, Kaslow JA, Lai KV, Levin JC, Miller AN, Rice JL, Tracy MC, Baker CD, Bauer SE, Cristea AI, Dawson SK, Eldredge L, Henningfeld JK, McKinney RL, Siddaiah R, Villafranco NM, Abman SH, McGrath-Morrow SA, Collaco JM: Outcomes of infants and children with bronchopulmonary dysplasia-associated pulmonary hypertension who required home ventilation. Pediatric Research January 2025.
Kelchtermans J, March ME, Hakonarson H, McGrath-Morrow SA.: Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children. Sci Rep. September 2024
McGlynn JR, Martin A, Aoyama BC, Bamat NA, Collaco JM, McGrath-Morrow SA: Bronchopulmonary dysplasia and diuretic use in an outpatient setting. Pediatr Pulmonol December 2024.
Aoyama BC, McGrath-Morrow SA, Collaco JM: Social Determinants of Health and somatic growth in preterm infants and children with chronic lung disease. Pediatric Pulmonology 59(12), December 2024.
Cynara Leon, Amanda Martin, Lisa R. Young, Brianna C. Aoyama, Jessica L. Rice, Jelte Kelchtersman, Joseph M. Collaco, Sharon A. McGrath-Morrow: Outpatient inhaled corticosteroid use in bronchopulmonary dysplasia. Pediatric Pulmonology November 2024.