Pradeep Kumar Gupta, Ph.D.

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Postdoctoral Researcher of Radiology
Research Associate, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Department: Radiology

Contact information
Laboratory of Molecular Imaging,
Department of Radiology, Perelman School of Medicine
B6 Blockley Hall, 423 Guardian Drive
University of Pennsylvania
Philadelphia, PA 19104
Office: 9179408621
Fax: 2155732113
Lab: 2157467387
Education:
B.Sc. (H) (Biotechnology)
Bundelkhand University, Jhansi, UP, India, 2007.
M.Sc. (Biotechnology)
Awadhesh Pratap Singh University, Rewa, MP, India, 2009.
Ph.D. (Neuroimaging Correlates of Vitamin B12 Deficiency)
King George’s Medical University, Lucknow, UP, India, 2014.
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Description of Clinical Expertise

My clinical expertise lies in advanced neuroimaging and oncologic imaging, with a strong emphasis on MR spectroscopy (¹H/³¹P), diffusion imaging, resting-state fMRI, perfusion MRI, and metabolic imaging. I specialize in identifying imaging biomarkers for diagnosis, therapeutic monitoring, and response assessment in neurological disorders and cancers, including lymphoma, melanoma, and brain injury. My translational work bridges preclinical and clinical research, leveraging cutting-edge technologies such as optical redox imaging, bioluminescence imaging, and high-field MRI. I actively collaborate with multidisciplinary teams to integrate imaging into precision medicine frameworks, ultimately enhancing patient care, early diagnosis, and individualized treatment strategies.

Description of Research Expertise

Experienced Imaging Scientist with expertise in image processing, data analysis, data collection, solution verification, manuscript preparation, statistical analysis, and validation. Aiming to drive innovation in the imaging technology field by leveraging “Medical imaging, cell signaling, cancer biology, drug treatment, immunotherapy, metabolic disorders, mitochondrial function assessment, neuropathology, neuropsychiatric disorders, T-cell metabolism, CAR T-cell therapy, metabolic flux and substrate analysis, preclinical MR imaging (9.4T, 4.7T), NMR (9.4T), clinical MR imaging (1.5T, 3T, 7T), metabolic and molecular imaging, optical redox imaging (ORI), and bioluminescence imaging (BLI).”

Selected Publications

Orlovskiy, S., Gupta, P. K., Arias-Mendoza, F., Singh, D. K., Nova, S., Nelson, D. S., Narayan, V., Koch, C. J., Hardy, M., You, M., Kalyanaraman, B., Nath, K.: Enhancing Radiation Therapy Response in Prostate Cancer Through Metabolic Modulation by Mito-Lonidamine: A 1H and 31P Magnetic Resonance Spectroscopy Study. Int J Mol Sci. MDPI, 26((2)): 509, Jan 2025.

Nath K, Gupta PK, Wang S, Rao S, Shestov AA, Sen N, Orlovskiy S, Lobello C, Rushmore D, Basappa J, Nelson DS, Arias-Mendoza F, Wasik MA.: Metabolic inhibition therapy targeting glutaminolysis in mantle cell lymphoma. ISMRM 2025 Notes: Honolulu, Hawaiʻi, USA.

Gupta PK, Li LZ, Singh DK, Nova S, Arias-Mendoza F, Orlovskiy S, Chawla S, Nelson DS, Farwell MD, Nath K.: MRS and Optical Imaging Studies of Therapeutic Response to Combination Therapy Targeting BRAF/MEK in Murine Melanomas. Acad Radiol. 2025.

Wang S, Lobello C, Jillab M, Rao S, Shah B, Mansoor N, Gupta PK, Rungsiprakarn P, Baldwin D, Dupoux V, Rushmore D, Mackrides N, Nath K, Nejati R, Johnvesly Basappa J, Wasik MA.: ROR1 Receptor as Oncogenic Driver in Mantle Cell Lymphoma. Lymphoma Research Foundation 2025 Notes: Chicago, Illinois, USA.

Gupta PK, Li LZ, Nova S, Orlovskiy S, Nelson DS, Arias-Mendoza F, Farwell M, Nath K.: Metabolic Biomarkers of Therapeutic Response in YUMM1.7 Melanoma Targeting BRAF and MEK Inhibition. ISMRM 2025 Notes: Honolulu, Hawaiʻi, USA.

Gupta PK, Orlovskiy S, Arias-Mendoza F, Nova S, Nelson DS, Pickup S, Farwell M, Nath K.: Metabolic and Functional Imaging Biomarkers of Response to Immunotherapy in Melanoma. ISMRM 2025 Notes: Honolulu, Hawaiʻi, USA.

Nath K, Gupta PK, Wang S, Shestov AA, Sen N, Rao S, Orlovskiy S, Lobello C, Rushmore D, Arias-Mendoza F, Basappa J, Nelson DS, Wasik MA.: Imaging Biomarkers of Glutaminolysis Inhibition in Mantle Cell Lymphoma Models. Lymphoma Research Foundation 2025 Notes: Chicago, Illinois, USA.

Gupta PK, Nath K, Rushmore D, Nova S, Arias-Mendoza F, Nelson DS, Wasik MA.: Pirtobrutinib Induced Metabolic Changes in MCL: Insights from 1H/31P Magnetic Resonance Spectroscopy. Lymphoma Research Foundation 2025 Notes: Chicago, Illinois, USA.

Nath K, Gupta PK, Wang S, Shestov AA, Sen N, Rao S, Orlovskiy S, Lobello C, Rushmore D, Arias-Mendoza F, Basappa J, Nelson DS, Wasik MA.: Magnetic resonance spectroscopy-based detection of response to therapy targeting glutaminolysis in lymphoma. Blood Neoplasia. American Society of Hematology, 2 ((3)): 100105, 2025 Notes: DOI: 10.1016/j.bneo.2025.100105.

Nath K., Gupta P. K., Wasik M. A.: Emerging Role of Functional Magnetic Resonance Spectroscopy (MRS) to Monitor Response to Kinase Inhibitors in Cancer. Adv Cancer Res Clin Imaging. irispublishers, Volume 4-Issue 3(ISSN: 2688-8203 ), Jul 5 2024 Notes: DOI: 10.33552/ACRCI.2024.04.000587.

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Last updated: 07/27/2025
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