John E Demko, MD
Assistant Professor of Clinical Medicine (Renal-Electrolyte and Hypertension)
Postdoctoral Researcher, University of California San Francisco, David Pearce’s Lab
Department: Medicine
Contact information
UCSF, Nephrology, Department of Medicine
259 5th Avenue
San Francisco, CA 94118
259 5th Avenue
San Francisco, CA 94118
Email:
john.demko@ucsf.edu
john.demko@ucsf.edu
Education:
BS (Biochemistry, Biotechnology Track)
Albright College, Bachelor of Science in Biochemistry, 2013.
MD (Medicine)
University of Pittsburgh School of Medicine, Pittsburgh, PA, 2017.
Permanent linkBS (Biochemistry, Biotechnology Track)
Albright College, Bachelor of Science in Biochemistry, 2013.
MD (Medicine)
University of Pittsburgh School of Medicine, Pittsburgh, PA, 2017.
Selected Publications
Demko JE, Saha B, Takagi E, Weber R, Pearce D: A Novel Function of FOXO4 and mTORC2 for Regulation of Renal Gluconeogenesis. Poster Presentation, American Society of Nephrology Kidney Week, San Diego, CA. Oct 2024.Judson TJ, Lo L, Demko JE, Mourad M, Liu KD, Wachter RM, Lopez I, Tummalapalli SL.: Addressing Inpatient Hyponatremia Through Targeted Automatic E-consults: A Pilot Randomized Trial. J Gen Intern Med Oct 22 2024.
Demko J, Weber R, Pearce D, Saha B.: Aldosterone-independent regulation of K + secretion in the distal nephron. Curr Opin Nephrol Hypertens 33(5): 526-534, Sep 1 2024.
Demko J, Saha B, Takagi E, Mannis A, Weber R, Pearce D.: Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium. bioRxiv Jun 27 2024.
Demko JE, Saha B, Takagi E, Manis A, Pearce D: High Potassium Suppresses Glycosuria in Tubule- specific mTORC2 Knockout Mice. Poster Presentation, American Society of Nephrology Kidney Week, Philadelphia, PA. Nov 2023.
Saha B, Shabbir W, Takagi E, Duan XP, Leite Dellova DCA, Demko J, Manis A, Loffing-Cueni D, Loffing J, Sørensen MV, Wang WH, Pearce D.: Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium. J Am Soc Nephrol 34(6): 1019-1038, Jun 2023.
Saha B, Leite-Dellova DCA, Demko J, Sørensen MV, Takagi E, Gleason CE, Shabbir W, Pearce D.: WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport. J Cell Sci 135(23): 260313, Dec 1 2022.
Demko JE, Saha B, Takagi E, Manis A, Richman P, Pearce D: Renal Tubule-Specific mTORC2 Deletion Increases Gluconeogenesis and Causes Glycosuria. Poster Presentation, American Society of Nephrology Kidney Week, Orlando, FL Nov 2022.
Saha B, Deise C, Takagi E, Demko J, Shabbir W, Pearce D: WNK1 is a Chloride-sensing Scaffold that Potentially Regulates mTORC2 Activity and ENaC. Poster Presentation, American Society of Nephrology Kidney Week, Orlando, FL. Nov 2022.
Shabbir W, Demko JE, Takagi E, Saha B, Leite-Dellova DC, Sambandam B, Pearce D: mTORC2 Is Essential for Sodium-Glucose Cotransporter. Poster Presentation, American Society of Nephrology Kidney Week (Virtual) Nov 2021.