Hillary C.M. Nelson, PhD, MPH

faculty photo
Associate Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics

Contact information
Department of Biochemistry and Biophysics
Philadelphia, PA 19104-6059
Office: 215-573-7473
BS (Molecular Biochemistry and Biophysics)
Yale University, 1979.
PhD (Biology (Biochemistry))
Massachusetts Institute of Technology, 1985.
Perelman School of Medicine, University of Pennsylvania, 2011.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Other Expertise

Public Health -

> How science impacts public health policy

> Evidence-Based Public Health

            - Worked to implement EBPH into the MPH curriculum -

            - Focus on opioid epidemic as an EPBPH topic

> Community Health

            * Currently Chair, Health Advisory Committee for Lower Merion Township *

            * Current focus on updating regulations for Body Art (tattooing and piercing) *

> Antibiotic Use in Food-Producing Animals

            - topic for MPH Capstone Project (2010)

            - Taught a seminar course on Antibiotic Resistance and Public Health for Penn freshmen *

> Affordable Care Act

            - worked with the Regional Health Administrator to educate his office about the new legislation (2010)

Science and grant writing -

> Teach science writing to BMB students in their pre-prelim grant writing course, with the philosophy of learning how to revise one's writing in light of how the reader perceives it

> Administer an internal study section for the Department of Biochemistry and Biophysics to help bolster success of external funding

> Edit faculty grants destined for NIH and other funding agencies in order to strengthen clarity, logic, and readability

Selected Publications

Conlin, L.C. and Nelson, H.C.M: Trehalose affects the transcriptional activity of yeast heat shock transcription factor. Mol. Cell. Biol 27: 1505-1515, 2007.

Eastmond, D.L. and Nelson, H.C.M. : Genome-wide analysis reveals new roles for the activation domains of the saccharomyces cerevisiae heat shock transcription factor (Hsf1) during the transient heat shock respons. J. Biol. Chem. 281: 32909-32921, 2006.

Ferguson, S.B., Anderson, E.S., Harshaw, R.B., Thate, T., Craig, N.L., and Nelson, H.C.M. : Protein Kinase A Regulates Constitutive Expression of Small Heat-Shock Genes in an Msn2/4p-Independent and Hsf1p-Dependent Manner in Saccharomyces cerevisiae. Genetics. Fred Winston (eds.). 169: 1203-1214, 2005.

Dashnau, J.L., Conlin, L.K., Nelson, H.C., and Vanderkooi, J.M. : Water structure in vitro and within Saccharomyces cerevisiae yeast cells under conditions of heat shock. Biochimica et Biophysica Acta 1780: 41-50, 2008.

Littlefield O., Nelson HC.: A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal. Nature Structural Biology 6(5): 464-70, May 1999.

Wyman C., Grotkopp E., Bustamante C., Nelson HC.: Determination of heat-shock transcription factor 2 stoichiometry at looped DNA complexes using scanning force microscopy. EMBO Journal 14(1): 117-23, Jan 3 1995.

Harrison, C.J., Bohm, A.A., and Nelson, H.C.M: Crystal structure of the DNA binding domain of the heat shock transcription factor. Science 263: 224-227, 1994.

Sorger PK., Nelson HC.: Trimerization of a yeast transcriptional activator via a coiled-coil motif. Cell 59(5): 807-13, Dec 1 1989.

Nelson HC., Finch JT., Luisi BF., Klug A.: The structure of an oligo(dA).oligo(dT) tract and its biological implications. Nature 330(6145): 221-6, Nov 19-25 1987.

Nelson HC., Sauer RT.: Lambda repressor mutations that increase the affinity and specificity of operator binding. Cell 42(2): 549-58, Sep 1985.

back to top
Last updated: 04/27/2018
The Trustees of the University of Pennsylvania