Hillary C.M. Nelson, PhD, MPH

faculty photo
Associate Professor of Biochemistry and Biophysics
Director, MPH Program
Director of Education, Center for Public Health Initiatives (CPHI)
Department: Biochemistry and Biophysics

Contact information
Department of Biochemistry and Biophysics
Department of Family Medicine and Community Health
Philadelphia, PA 19104-6059
Office: 215-746-8554
BS (Molecular Biochemistry and Biophysics)
Yale University, 1979.
PhD (Biology (Biochemistry))
Massachusetts Institute of Technology, 1985.
Perelman School of Medicine, University of Pennsylvania, 2011.
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Description of Other Expertise

Interprofessional Education

Selected Publications

Conlin, L.C. and Nelson, H.C.M: Trehalose affects the transcriptional activity of yeast heat shock transcription factor. Mol. Cell. Biol 27: 1505-1515, 2007.

Eastmond, D.L. and Nelson, H.C.M. : Genome-wide analysis reveals new roles for the activation domains of the saccharomyces cerevisiae heat shock transcription factor (Hsf1) during the transient heat shock respons. J. Biol. Chem. 281: 32909-32921, 2006.

Ferguson, S.B., Anderson, E.S., Harshaw, R.B., Thate, T., Craig, N.L., and Nelson, H.C.M. : Protein Kinase A Regulates Constitutive Expression of Small Heat-Shock Genes in an Msn2/4p-Independent and Hsf1p-Dependent Manner in Saccharomyces cerevisiae. Genetics. Fred Winston (eds.). 169: 1203-1214, 2005.

Dashnau, J.L., Conlin, L.K., Nelson, H.C., and Vanderkooi, J.M. : Water structure in vitro and within Saccharomyces cerevisiae yeast cells under conditions of heat shock. Biochimica et Biophysica Acta 1780: 41-50, 2008.

Littlefield O., Nelson HC.: A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal. Nature Structural Biology 6(5): 464-70, May 1999.

Wyman C., Grotkopp E., Bustamante C., Nelson HC.: Determination of heat-shock transcription factor 2 stoichiometry at looped DNA complexes using scanning force microscopy. EMBO Journal 14(1): 117-23, Jan 3 1995.

Harrison, C.J., Bohm, A.A., and Nelson, H.C.M: Crystal structure of the DNA binding domain of the heat shock transcription factor. Science 263: 224-227, 1994.

Sorger PK., Nelson HC.: Trimerization of a yeast transcriptional activator via a coiled-coil motif. Cell 59(5): 807-13, Dec 1 1989.

Nelson HC., Finch JT., Luisi BF., Klug A.: The structure of an oligo(dA).oligo(dT) tract and its biological implications. Nature 330(6145): 221-6, Nov 19-25 1987.

Nelson HC., Sauer RT.: Lambda repressor mutations that increase the affinity and specificity of operator binding. Cell 42(2): 549-58, Sep 1985.

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Last updated: 10/26/2023
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