Selected Publications

Burns R, Changolkar L, and Lázaro DF: Generation of amplified aSyn Lewy Bodies. In preparation to be submit in April 2025.

Lázaro DF, Lee VM: Navigating through the complexities of synucleinopathies: Insights into pathogenesis, heterogeneity, and future perspectives. Neuron 112(18): 3029-3042, 2024.

Lázaro DF*, Amen T, Gerhardt E, Song C, Kruse N, Santos PI, Milovanovic D, Höglinger G, Mollenhauer B, Luk KC, Lee VMY, and Outeiro TF*: Synphilin-1 as a modulator of aSyn assembly. https://www.researchsquare.com/article/rs-2923196/v1 2023 Notes: *corresponding author.

Schaffner SL, Wassouf Z, Lazaro DF, Xylaki M, Gladish N, Lin DTS, MacIsaac J, Ramadori K, Hentrich T, Schulze-Hentrich JM, Outeiro TF, Kobor MS: Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways. Hum Mol Genet 31(21): 3694-3714, Oct 2022.

Flores-León M*, Lázaro DF*, Shvachiy L*, Krisko A, Outeiro TF: In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies. Biochim Biophys Acta Proteins Proteom. *equal contribution, 1869(10), Oct 2021.

Popova B, Wang D, Rajavel A, Dhamotharan K, Lázaro DF, Gerke J, Uhrig JF, Hoppert M, Outeiro TF, Braus GH: Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation. Front Mol Neurosci 12(14): 659926, Apr 2021.

Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF: Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo. Neurobiol Dis 151, Apr 2021.

Popova B, Wang D, Pätz C, Akkermann D, Lázaro DF, Galka D, Kolog Gulko M, Bohnsack MT, Möbius W, Bohnsack KE, Outeiro TF, Braus GH: DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization. PLoS Genet 17(3): e1009407, Mar 2021.

Weish P*, Lázaro DF*$, Palmares L, Santos PI, Stadelmann C, Höglinger GU, Rizzoli SO, Outeiro TF$: Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain. doi: https://doi.org/10.1101/2021.04.25.441304 2021 Notes: *equal contribution $corresponding author.

Cukierman DS, Lázaro DF, Sacco P, Ferreira PR, Diniz R, Fernández CO, Outeiro TF, Rey NA: X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(I)/copper(II)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy. Dalton Trans 49: 16252-16267, Nov 2020.