Jilian R Melamed, PhD
Research Assistant Professor of Medicine (Infectious Diseases)
Department: Medicine
Contact information
25 N 38th St
One uCity Square
Philadelphia, PA 19104
One uCity Square
Philadelphia, PA 19104
Office: 7325735052
Publications
Education:
BS (Biomedical Engineering)
Rutgers University, 2013.
PhD (Biomedical Engineering)
University of Delaware, 2018.
Permanent linkBS (Biomedical Engineering)
Rutgers University, 2013.
PhD (Biomedical Engineering)
University of Delaware, 2018.
Description of Research Expertise
RNA therapeuticsNanomedicine
Drug delivery
Selected Publications
Jilian R Melamed, Saigopalakrishna S Yerneni, Mariah L Arral, Samuel T LoPresti, Namit Chaudhary, Anuradha Sehrawat, Hiromi Muramatsu, Mohamad-Gabriel Alameh, Norbert Pardi, Drew Weissman, George K Gittes, Kathryn A Whitehead: Ionizable lipid nanoparticles deliver mRNA to pancreatic beta cells via macrophage-mediated gene transfer. Science Advances 9(4): eade1444, Jan 2023.Rose Doerfler, Jilian R Melamed, Kathryn A Whitehead: The effect of infant gastric digestion on human maternal milk cells. Molecular Nutrition & Food Research 66(19): 2200090, Oct 2022.
Nicholas G Lamson, Katherine C Fein, John P Gleeson, Alexandra N Newby, Sijie Xian, Kyle Cochran, Namit Chaudhary, Jilian R Melamed, Rebecca L Ball, Kanika Suri, Vishal Ahuja, Anna Zhang, Adrian Berger, Dmytro Kolodieznyi, Brigitte F Schmidt, Gloria L Silva, Kathryn A Whitehead: The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery. Proceedings of the National Academy of Sciences USA 119(33): e2207829119, Aug 2022.
Katherine C Fein, John P Gleeson, Kyle Cochran, Nicholas G Lamson, Rose Doerfler, Jilian R Melamed, Kathryn A Whitehead: Long-term daily oral administration of intestinal permeation enhancers is safe and effective in mice. Bioengineering & Translational Medicine 8(1): e10342, May 2022.
Jilian R Melamed, Khalid A HAjj, Namit Chaudhary, Daria Strelkova, Mariah L Arral, Norbert Pardi, Mohamad-Gabriel Alameh, Jason B Miller, Lukas Farbiak, Daniel J Siegwart, Drew Weissman, Kathryn A Whitehead: Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. Journal of Controlled Release 341(1): 206-214, Jan 2022.
Shoaib Iqbal, Benjamin Luo, Jilian R Melamed, Emily S Day: Critical evaluation of different lysosomal labeling methods used to analyze RNA nanocarrier trafficking in cells. Bioconjugate Chemistry 32(10): 2245-2256, Oct 2021.
Khalid A Hajj, Jilian R Melamed, Namit Chaudhary, Nicholas G Lamson, Rebecca L Ball, Saigopalakrishna S Yerneni, Kathryn A Whitehead: A potent branched-tail lipid nanoparticle enables multiplexed mRNA delivery and gene editing in vivo. Nano Letters 20(7): 5167-517, Jul 2020.
Jilian R Melamed, Stephen A Ioele, Ariel J Hannum, Violet M Ullman, Emily S Day: Polyethylenimine-spherical nucleic acid nanoparticles against Gli1 reduce the chemoresistance and stemness of glioblastoma cells. Molecular Pharmaceutics 15(11): 5135–5145, Nov 2018.
Ritu Goyal, Chintan H Kapadia, Jilian R Melamed, Rachel S Riley, Emily S Day: Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. Cellular and Molecular Bioengineering 11(5): 383-396, Oct 2018.
Jilian R Melamed, Nicole L Kreuzberger, Ritu Goyal, Emily S Day: Spherical nucleic acid architecture can improve the efficacy of polycation-mediated siRNA delivery. Molecular Therapy - Nucleic Acids 12: 207-219, Sep 2018.