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Jilian R Melamed, PhD
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Research Assistant Professor of Medicine (Infectious Diseases)
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Department: Medicine
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Contact information
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25 N 38th St
33 One uCity Square
Philadelphia, PA 19104
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33 One uCity Square
Philadelphia, PA 19104
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Office: 7325735052
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Publications
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Links
ac Search PubMed for articles
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ac Search PubMed for articles
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Education:
21 7 BS 23 (Biomedical Engineering) c
2b Rutgers University, 2013.
21 8 PhD 23 (Biomedical Engineering) c
2f University of Delaware, 2018.
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Permanent link21 7 BS 23 (Biomedical Engineering) c
2b Rutgers University, 2013.
21 8 PhD 23 (Biomedical Engineering) c
2f University of Delaware, 2018.
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14 Nanomedicine
14 Drug delivery
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Description of Research Expertise
21 RNA therapeutics14 Nanomedicine
14 Drug delivery
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102 Rose Doerfler, Jilian R Melamed, Kathryn A Whitehead: The effect of infant gastric digestion on human maternal milk cells. Molecular Nutrition & Food Research 66(19): 2200090, Oct 2022.
20b Nicholas G Lamson, Katherine C Fein, John P Gleeson, Alexandra N Newby, Sijie Xian, Kyle Cochran, Namit Chaudhary, Jilian R Melamed, Rebecca L Ball, Kanika Suri, Vishal Ahuja, Anna Zhang, Adrian Berger, Dmytro Kolodieznyi, Brigitte F Schmidt, Gloria L Silva, Kathryn A Whitehead: The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery. Proceedings of the National Academy of Sciences USA 119(33): e2207829119, Aug 2022.
167 Katherine C Fein, John P Gleeson, Kyle Cochran, Nicholas G Lamson, Rose Doerfler, Jilian R Melamed, Kathryn A Whitehead: Long-term daily oral administration of intestinal permeation enhancers is safe and effective in mice. Bioengineering & Translational Medicine 8(1): e10342, May 2022.
1b0 Jilian R Melamed, Khalid A HAjj, Namit Chaudhary, Daria Strelkova, Mariah L Arral, Norbert Pardi, Mohamad-Gabriel Alameh, Jason B Miller, Lukas Farbiak, Daniel J Siegwart, Drew Weissman, Kathryn A Whitehead: Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. Journal of Controlled Release 341(1): 206-214, Jan 2022.
129 Shoaib Iqbal, Benjamin Luo, Jilian R Melamed, Emily S Day: Critical evaluation of different lysosomal labeling methods used to analyze RNA nanocarrier trafficking in cells. Bioconjugate Chemistry 32(10): 2245-2256, Oct 2021.
15c Khalid A Hajj, Jilian R Melamed, Namit Chaudhary, Nicholas G Lamson, Rebecca L Ball, Saigopalakrishna S Yerneni, Kathryn A Whitehead: A potent branched-tail lipid nanoparticle enables multiplexed mRNA delivery and gene editing in vivo. Nano Letters 20(7): 5167-517, Jul 2020.
152 Jilian R Melamed, Stephen A Ioele, Ariel J Hannum, Violet M Ullman, Emily S Day: Polyethylenimine-spherical nucleic acid nanoparticles against Gli1 reduce the chemoresistance and stemness of glioblastoma cells. Molecular Pharmaceutics 15(11): 5135–5145, Nov 2018.
12a Ritu Goyal, Chintan H Kapadia, Jilian R Melamed, Rachel S Riley, Emily S Day: Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. Cellular and Molecular Bioengineering 11(5): 383-396, Oct 2018.
126 Jilian R Melamed, Nicole L Kreuzberger, Ritu Goyal, Emily S Day: Spherical nucleic acid architecture can improve the efficacy of polycation-mediated siRNA delivery. Molecular Therapy - Nucleic Acids 12: 207-219, Sep 2018.
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Selected Publications
1c1 Jilian R Melamed, Saigopalakrishna S Yerneni, Mariah L Arral, Samuel T LoPresti, Namit Chaudhary, Anuradha Sehrawat, Hiromi Muramatsu, Mohamad-Gabriel Alameh, Norbert Pardi, Drew Weissman, George K Gittes, Kathryn A Whitehead: Ionizable lipid nanoparticles deliver mRNA to pancreatic beta cells via macrophage-mediated gene transfer. Science Advances 9(4): eade1444, Jan 2023.102 Rose Doerfler, Jilian R Melamed, Kathryn A Whitehead: The effect of infant gastric digestion on human maternal milk cells. Molecular Nutrition & Food Research 66(19): 2200090, Oct 2022.
20b Nicholas G Lamson, Katherine C Fein, John P Gleeson, Alexandra N Newby, Sijie Xian, Kyle Cochran, Namit Chaudhary, Jilian R Melamed, Rebecca L Ball, Kanika Suri, Vishal Ahuja, Anna Zhang, Adrian Berger, Dmytro Kolodieznyi, Brigitte F Schmidt, Gloria L Silva, Kathryn A Whitehead: The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery. Proceedings of the National Academy of Sciences USA 119(33): e2207829119, Aug 2022.
167 Katherine C Fein, John P Gleeson, Kyle Cochran, Nicholas G Lamson, Rose Doerfler, Jilian R Melamed, Kathryn A Whitehead: Long-term daily oral administration of intestinal permeation enhancers is safe and effective in mice. Bioengineering & Translational Medicine 8(1): e10342, May 2022.
1b0 Jilian R Melamed, Khalid A HAjj, Namit Chaudhary, Daria Strelkova, Mariah L Arral, Norbert Pardi, Mohamad-Gabriel Alameh, Jason B Miller, Lukas Farbiak, Daniel J Siegwart, Drew Weissman, Kathryn A Whitehead: Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. Journal of Controlled Release 341(1): 206-214, Jan 2022.
129 Shoaib Iqbal, Benjamin Luo, Jilian R Melamed, Emily S Day: Critical evaluation of different lysosomal labeling methods used to analyze RNA nanocarrier trafficking in cells. Bioconjugate Chemistry 32(10): 2245-2256, Oct 2021.
15c Khalid A Hajj, Jilian R Melamed, Namit Chaudhary, Nicholas G Lamson, Rebecca L Ball, Saigopalakrishna S Yerneni, Kathryn A Whitehead: A potent branched-tail lipid nanoparticle enables multiplexed mRNA delivery and gene editing in vivo. Nano Letters 20(7): 5167-517, Jul 2020.
152 Jilian R Melamed, Stephen A Ioele, Ariel J Hannum, Violet M Ullman, Emily S Day: Polyethylenimine-spherical nucleic acid nanoparticles against Gli1 reduce the chemoresistance and stemness of glioblastoma cells. Molecular Pharmaceutics 15(11): 5135–5145, Nov 2018.
12a Ritu Goyal, Chintan H Kapadia, Jilian R Melamed, Rachel S Riley, Emily S Day: Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. Cellular and Molecular Bioengineering 11(5): 383-396, Oct 2018.
126 Jilian R Melamed, Nicole L Kreuzberger, Ritu Goyal, Emily S Day: Spherical nucleic acid architecture can improve the efficacy of polycation-mediated siRNA delivery. Molecular Therapy - Nucleic Acids 12: 207-219, Sep 2018.
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