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Matthew Thomas Whitehead, MD
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Associate Professor of Radiology at the Children's Hospital of Philadelphia
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Active Medical Staff, Hospital of the University of Pennsylvania, Department of Radiology, Philadelphia, PA
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Active Medical Staff, Chester County Hospital, Department of Radiology, Philadelphia, PA
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Active Medical Staff, Pennsylvania Hospital, Department of Radiology, Philadelphia, PA
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Pediatric Neuroradiologist, Children's Hospital of Philadelphia, Department of Radiology, Division of Neuroradiology, Philadelphia, PA
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Director, Fetal and Neonatal Neuroimaging, Children's Hospital of Philadelphia, Department of Radiology, Philadelphia, PA
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Department: Radiology
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Contact information
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Children's Hospital of Philadelphia
1f Department of Radiology
22 Division of Neuroradiology
3a 3401 Civic Center Blvd.
Philadelphia, PA 19104
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1f Department of Radiology
22 Division of Neuroradiology
3a 3401 Civic Center Blvd.
Philadelphia, PA 19104
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Office: 215-590-1000
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Email:
whiteheadm@chop.edu
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whiteheadm@chop.edu
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Education:
21 7 BS 31 (Biology and Chemistry (Dual Degree) ) c
46 University of Tennessee at Martin, Martin, TN, 2000.
21 7 MD 1f (Doctor of Medicine) c
4e University Tennessee College of Medicine, Memphis, TN, 2004.
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Permanent link21 7 BS 31 (Biology and Chemistry (Dual Degree) ) c
46 University of Tennessee at Martin, Martin, TN, 2000.
21 7 MD 1f (Doctor of Medicine) c
4e University Tennessee College of Medicine, Memphis, TN, 2004.
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160 Simsek O, Manteghinejad A, Wannasarnmetha M, Kotha A, Teixeira SR, Zarnow D, Schwartz ES, Whitehead MT.: Subarachnoid Space Measurements in the Second Trimester Using MR Imaging. AJNR. American journal of neuroradiology 46(10): 2168-2175, Sep 2025 Notes: DOI: 10.3174/ajnr.A8773.
258 Dominguez Gonzalez CA, Bell KM, Rajagopalan R, de Silva MG, Lemes A, Zabala C, Perez-Vidarte F, Cerisola A, Vossough A, Whitehead MT, Cunningham C, Brown NJ, Quin R, Simons C, Conway T, Uebergang E, Rius R, Kumaheri MA, Kotes ER, Vohra A, Zalusky MPG, Anderson ZB, Storz SHR, Ward SA, Goffena J, Gustafson JA, White SM, Vanderver A, Miller DE.: Deep Intronic SVA_E Insertion Identified as the Most Common Pathogenic Variant Associated With Canavan Disease: A Diagnostic Blind Spot. Neurology. Genetics 11(5): e200291, Sep 2025.
1ff DiSanza BL, Porcari GS, Finoti LS, Ramos-Rodriguez L, Burris DM, McDonough JA, Ning G, Fagan G, Helman GT, Weiss E, Taft RJ, Pizzino A, Whitehead MT, Waldman A, Simons C, Ortiz-Gonzalez X, Skarnes WC, Vanderver A, Bhoj EJ, Ahrens-Nicklas RC.: Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder. HGG advances 7(1): 100525, Sep 2025 Notes: DOI: 10.1016/j.xhgg.2025.100525.
1ca Coppola F, Prasad S, Morana G, Whitehead MT, Zakzouk R, Manteghinejad A, Langer FW, Perez JA, D'Arco F, Löbel U, Gaur P, Varga P, Baruteau J, Mankad K, Sudhakar S, Biswas A.: Neuroimaging spectrum of GM1 gangliosidosis with description of novel imaging signs. AJNR. American journal of neuroradiology Aug 2025 Notes: DOI: 10.3174/ajnr.A8973; Online ahead of print as of November 2025.
157 Wright R, Burrill N, Crane H, Khalek N, Gebb J, Bach AM, Whitehead MT, Zarnow D, Oliver E, Agarwal S, Moldenhauer JS.: Case Series of Prenatally Diagnosed Cri du Chat Syndrome With Associated Magnetic Resonance Imaging Findings. Pediatric neurology 169: 93-97, Aug 2025.
139 Whitehead MT, Manteghinejad A, Alves CAPF, Simsek O, Khalek N, Schwartz ES: Frontal Paraventricular Cysts: Refined Definitions and Outcomes. AJNR. American journal of neuroradiology 46(8): 1709-1715, Aug 2025 Notes: DOI: 10.3174/ajnr.A8653.
129 Kukulka NA, Singh S, Whitehead MT, Dobyns WB, Chang T, Kousa YA.: Pontocerebellar hypoplasia: a review from 1912 to 2022. Brain communications 7(5): fcaf298, Aug 2025 Notes: DOI: 10.1093/braincomms/fcaf298; eCollection 2025.
186 Martinez-Correa S, Rafful PP, Ramirez-Suarez KI, Viaene AN, Beslow LA, Agarwal S, Whitehead MT, Vossough A, Teixeira SR.: Imaging Patterns of Neonatal Subpial Hemorrhage: Provisional Statements on Neurologic Outcomes. AJNR. American journal of neuroradiology 46(8): 1702-1708, Aug 2025 Notes: DOI: 10.3174/ajnr.A8702.
309 De Pace R, Gonzalez CD, Williamson CD, Helman G, Sanderson LE, Disanza B, Hsiao-Sánchez N, Pizzino A, Muirhead K, Bonkowsky JL, Taft RJ, Sannaa NA, Dias P, Quintas AS, Mutlu MB, Bas H, Oztürk H, Mojarrad M, Alerasool M, Sheikhani S, Jabbar HK, Issa AH, Houlden H, Zonic E, Barakat TS, Tripolski K, Romito A, Teferedegn E, Vossough A, Whitehead MT, Bhoj E, Ahrens-Nicklas RC, Simons C, Wolvetang E, van Ham TJ, Bertoli-Avella AM, Maroofian R, Bonifacino JS, Vanderver A.: BLOC1S1 variants cause lysosomal and autophagic defects resulting in a hypomyelinating leukodystrophy with epileptic encephalopathy. medRxiv: the preprint server for health sciences Jul 2025 Notes: DOI: 10.1101/2025.07.17.25331211.
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Selected Publications
1a8 Mahecha M, Perdomo C, Goncalves FG, Whitehead MT.: Developmental Milestones, Molecular Gatekeepers and MRI Tools for Accurate Recognition of Hypomyelinating and Delayed Myelination Syndromes. Radiological Society of North America (RSNA) Scientific Assembly and Annual Meeting, Chicago, IL Nov 2026 Notes: Accepted for poster presentation at RSNA 2026.160 Simsek O, Manteghinejad A, Wannasarnmetha M, Kotha A, Teixeira SR, Zarnow D, Schwartz ES, Whitehead MT.: Subarachnoid Space Measurements in the Second Trimester Using MR Imaging. AJNR. American journal of neuroradiology 46(10): 2168-2175, Sep 2025 Notes: DOI: 10.3174/ajnr.A8773.
258 Dominguez Gonzalez CA, Bell KM, Rajagopalan R, de Silva MG, Lemes A, Zabala C, Perez-Vidarte F, Cerisola A, Vossough A, Whitehead MT, Cunningham C, Brown NJ, Quin R, Simons C, Conway T, Uebergang E, Rius R, Kumaheri MA, Kotes ER, Vohra A, Zalusky MPG, Anderson ZB, Storz SHR, Ward SA, Goffena J, Gustafson JA, White SM, Vanderver A, Miller DE.: Deep Intronic SVA_E Insertion Identified as the Most Common Pathogenic Variant Associated With Canavan Disease: A Diagnostic Blind Spot. Neurology. Genetics 11(5): e200291, Sep 2025.
1ff DiSanza BL, Porcari GS, Finoti LS, Ramos-Rodriguez L, Burris DM, McDonough JA, Ning G, Fagan G, Helman GT, Weiss E, Taft RJ, Pizzino A, Whitehead MT, Waldman A, Simons C, Ortiz-Gonzalez X, Skarnes WC, Vanderver A, Bhoj EJ, Ahrens-Nicklas RC.: Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder. HGG advances 7(1): 100525, Sep 2025 Notes: DOI: 10.1016/j.xhgg.2025.100525.
1ca Coppola F, Prasad S, Morana G, Whitehead MT, Zakzouk R, Manteghinejad A, Langer FW, Perez JA, D'Arco F, Löbel U, Gaur P, Varga P, Baruteau J, Mankad K, Sudhakar S, Biswas A.: Neuroimaging spectrum of GM1 gangliosidosis with description of novel imaging signs. AJNR. American journal of neuroradiology Aug 2025 Notes: DOI: 10.3174/ajnr.A8973; Online ahead of print as of November 2025.
157 Wright R, Burrill N, Crane H, Khalek N, Gebb J, Bach AM, Whitehead MT, Zarnow D, Oliver E, Agarwal S, Moldenhauer JS.: Case Series of Prenatally Diagnosed Cri du Chat Syndrome With Associated Magnetic Resonance Imaging Findings. Pediatric neurology 169: 93-97, Aug 2025.
139 Whitehead MT, Manteghinejad A, Alves CAPF, Simsek O, Khalek N, Schwartz ES: Frontal Paraventricular Cysts: Refined Definitions and Outcomes. AJNR. American journal of neuroradiology 46(8): 1709-1715, Aug 2025 Notes: DOI: 10.3174/ajnr.A8653.
129 Kukulka NA, Singh S, Whitehead MT, Dobyns WB, Chang T, Kousa YA.: Pontocerebellar hypoplasia: a review from 1912 to 2022. Brain communications 7(5): fcaf298, Aug 2025 Notes: DOI: 10.1093/braincomms/fcaf298; eCollection 2025.
186 Martinez-Correa S, Rafful PP, Ramirez-Suarez KI, Viaene AN, Beslow LA, Agarwal S, Whitehead MT, Vossough A, Teixeira SR.: Imaging Patterns of Neonatal Subpial Hemorrhage: Provisional Statements on Neurologic Outcomes. AJNR. American journal of neuroradiology 46(8): 1702-1708, Aug 2025 Notes: DOI: 10.3174/ajnr.A8702.
309 De Pace R, Gonzalez CD, Williamson CD, Helman G, Sanderson LE, Disanza B, Hsiao-Sánchez N, Pizzino A, Muirhead K, Bonkowsky JL, Taft RJ, Sannaa NA, Dias P, Quintas AS, Mutlu MB, Bas H, Oztürk H, Mojarrad M, Alerasool M, Sheikhani S, Jabbar HK, Issa AH, Houlden H, Zonic E, Barakat TS, Tripolski K, Romito A, Teferedegn E, Vossough A, Whitehead MT, Bhoj E, Ahrens-Nicklas RC, Simons C, Wolvetang E, van Ham TJ, Bertoli-Avella AM, Maroofian R, Bonifacino JS, Vanderver A.: BLOC1S1 variants cause lysosomal and autophagic defects resulting in a hypomyelinating leukodystrophy with epileptic encephalopathy. medRxiv: the preprint server for health sciences Jul 2025 Notes: DOI: 10.1101/2025.07.17.25331211.
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