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Christina Jackson, M.D.
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Assistant Professor of Neurosurgery at the Hospital of the University of Pennsylvania
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Department: Neurosurgery
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Contact information
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Department of Neurosurgery
40 Perelman School of Medicine, University of Pennsylvania
25 PCAM, 3400 Civic Center Blvd.
36 15-137, South Tower
Philadelphia, PA 19104
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40 Perelman School of Medicine, University of Pennsylvania
25 PCAM, 3400 Civic Center Blvd.
36 15-137, South Tower
Philadelphia, PA 19104
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Publications
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Education:
21 7 BS 26 (Architectural Engineering) c
36 University of Texas at Austin, 2009.
21 7 MD 15 (Medicine) c
2f Harvard Medical School, 2014.
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Permanent link21 7 BS 26 (Architectural Engineering) c
36 University of Texas at Austin, 2009.
21 7 MD 15 (Medicine) c
2f Harvard Medical School, 2014.
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205 Dr. Jackson received her medical degree from Harvard Medical School prior to completing her neurosurgery residency at Johns Hopkins University School of Medicine. She then completed a dedicated fellowship at the University of Pittsburgh Medical Center focusing on endoscopic endonasal and open skull base surgical techniques. Dr. Jackson is uniquely trained in both open and endoscopic endonasal skull base approaches and aims to select the most effective and less invasive approach to each individual patient.
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Description of Clinical Expertise
218 Dr. Christina Jackson is an Assistant Professor of Neurosurgery at the Hospital of the University of Pennsylvania. She specializes in open skull base surgery, minimally invasive surgery, endoscopic skull base and pituitary surgery, and complex brain tumor surgery. Her clinical expertise is in the treatment of benign and malignant brain tumors with special interest in skull base tumors include pituitary adenomas, meningiomas, craniopharyngiomas, chordomas, chondrosarcomas, schwannomas, and esthesioneuroblastomas.8
205 Dr. Jackson received her medical degree from Harvard Medical School prior to completing her neurosurgery residency at Johns Hopkins University School of Medicine. She then completed a dedicated fellowship at the University of Pittsburgh Medical Center focusing on endoscopic endonasal and open skull base surgical techniques. Dr. Jackson is uniquely trained in both open and endoscopic endonasal skull base approaches and aims to select the most effective and less invasive approach to each individual patient.
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Description of Research Expertise
312 The focus of our lab’s research is at the intersection of immunology, metabolism, and brain tumor biology. The primary goal of our translational research is to understand mechanisms of immune evasion by primary malignant brain tumors and skull base tumors to generate novel immune-based therapies. We utilize a combination of high-dimensional single cell immune and genomic profiling, metabolomics, and advanced tumor organoid and mouse models, to 1) understand the role of myeloid derived suppressor cells in promoting tumor growth and T cell dysfunction, 2) elucidate the mechanisms of tumor-specific T cell exhaustion and clonal lineage of dysfunction T cells, and 3) understand how metabolic networks control immune cell function within the tumor microenvironment.e 29
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240 Chongsathidkiet, P., Jackson, C., Koyama, S., Loebel, F., Cui, X., Farber, S. H., Woroniecka, K., Elsamadicy, A. A., Dechant, C. A., Kemeny, H. R., Sanchez-Perez, L., Cheema, T. A., Souders, N. C., Herndon, J. E., Coumans, J. V., Everitt, J. I., Nahed, B. V., Sampson, J. H., Gunn, M. D., Martuza, R. L., Dranoff, G., Curry, W. T., Fecci, P. E.: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nat Med 24(9): 1459-1468, Sep 2018.
139 Jackson, C., Tadokoro, K.S., Wang, E.W., Zenonos, G.A., Snyderman, C.H., Gardner, P.A.: Approach selection for resection of petroclival meningioma. Neurosurgical Focus: Video. American Association of Neurological Surgeons, 6(2), April 2022.
16e Jackson, C., Chan, Y.K., Stefko, S.T., Zenonos, G.A., Gardner, P.A.: Lateral orbitotomy for resection for resection of trigeminal schwannoma. J Neurol Surg B Skull Base 83(S01): S1-S270, February 2022 Notes: Poster presentation at North American Society of Skull Base Surgery Annual Meeting.
17d Jackson, C., Kong, D.K., Gersey, Z.C., Wang, E.W., Zenonos, G., Snyderman, C.H., Gardner, P.A.: Contact endoscopy as a novel technique for intra-operative identification of normal pituitary gland and adenoma. Neurosurgical Focus: Video. American Association of Neurological Surgeons, 6(1): V17, January 2022.
ad Jackson, C., Lim, M.: Bespoke immunotherapy: how close are we? Neuro Oncol 21(3): 289-290, Feb 2019.
149 Jackson, C., Vo, C., Daniels, M., Chaichana, K.: Clinical Predictors of Tumor Recurrence after Pituitary Adenoma Resection. Neuro-Oncology 21(Supplement_6): vi246-vi247, November 2019 Notes: Poster presentation at Society of Neuro-oncology Annual Meeting.
1e7 Medikonda, R., Choi, J., Pant, A., Saleh, L., Routkevitch, D., Tong, L., Belcaid, Z., Kim, Young H, Jackson, C.M., Jackson, C., Mathios, D., Xia, Y., Shah, P.P, Patel, K., Kim, T., Srivastava, S., Huq, S., Ehresman, J., Pennington, Z., Tyler, B., Brem, H., Lim, M.: Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma. J Neurosurg 136(2): 378-388, Aug 2021.
1c1 Tosi, U. Jackson, C. D'Souza, Rabinowitz, M., Farrell, C., Parsel, S., Anand, V., Kacker, A., Tabaee, A., Zenonos, G., Snyderman, C., Wang, E., Evans, J., Rosen, M., Nyquist, G., Gardner, P., Schwartz, T.: Endoscopic Endonasal repair of encephloceles of the lateral sphenoid sinus: multi-institution confirmation of a new classification J Neurosurg 140(3): 705-711, Sep 2023.
137 Jackson, C., Fernandes-Cabral, D., Stefko, ST., Wang, E., Zenonos, G., Snyderman, CH., Gardner, PA.: Combined transorbital neuroendoscopic and endoscopic endonasal resection of orbital hemangioma. Neurosurgical Focus Video 16, April 2025.
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Selected Publications
218 Jackson, C., Cherry, C., Bom, S., Dykema, A. G., Wang, R., Thompson, E., Zhang, M., Li, R., Ji, Z., Hou, W., Zhan, W., Zhang, H., Choi, J., Vaghasia, A., Hansen, L., Wang, W., Bergsneider, B., Jones, K. M., Rodriguez, F., Weingart, J., Lucas, C. H., Powell, J., Elisseeff, J., Yegnasubramanian, S., Lim, M., Bettegowda, C., Ji, H., Pardoll, D.: Distinct myeloid-derived suppressor cell populations in human glioblastoma. Science 387(6731): eabm5214, January 2025.240 Chongsathidkiet, P., Jackson, C., Koyama, S., Loebel, F., Cui, X., Farber, S. H., Woroniecka, K., Elsamadicy, A. A., Dechant, C. A., Kemeny, H. R., Sanchez-Perez, L., Cheema, T. A., Souders, N. C., Herndon, J. E., Coumans, J. V., Everitt, J. I., Nahed, B. V., Sampson, J. H., Gunn, M. D., Martuza, R. L., Dranoff, G., Curry, W. T., Fecci, P. E.: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nat Med 24(9): 1459-1468, Sep 2018.
139 Jackson, C., Tadokoro, K.S., Wang, E.W., Zenonos, G.A., Snyderman, C.H., Gardner, P.A.: Approach selection for resection of petroclival meningioma. Neurosurgical Focus: Video. American Association of Neurological Surgeons, 6(2), April 2022.
16e Jackson, C., Chan, Y.K., Stefko, S.T., Zenonos, G.A., Gardner, P.A.: Lateral orbitotomy for resection for resection of trigeminal schwannoma. J Neurol Surg B Skull Base 83(S01): S1-S270, February 2022 Notes: Poster presentation at North American Society of Skull Base Surgery Annual Meeting.
17d Jackson, C., Kong, D.K., Gersey, Z.C., Wang, E.W., Zenonos, G., Snyderman, C.H., Gardner, P.A.: Contact endoscopy as a novel technique for intra-operative identification of normal pituitary gland and adenoma. Neurosurgical Focus: Video. American Association of Neurological Surgeons, 6(1): V17, January 2022.
ad Jackson, C., Lim, M.: Bespoke immunotherapy: how close are we? Neuro Oncol 21(3): 289-290, Feb 2019.
149 Jackson, C., Vo, C., Daniels, M., Chaichana, K.: Clinical Predictors of Tumor Recurrence after Pituitary Adenoma Resection. Neuro-Oncology 21(Supplement_6): vi246-vi247, November 2019 Notes: Poster presentation at Society of Neuro-oncology Annual Meeting.
1e7 Medikonda, R., Choi, J., Pant, A., Saleh, L., Routkevitch, D., Tong, L., Belcaid, Z., Kim, Young H, Jackson, C.M., Jackson, C., Mathios, D., Xia, Y., Shah, P.P, Patel, K., Kim, T., Srivastava, S., Huq, S., Ehresman, J., Pennington, Z., Tyler, B., Brem, H., Lim, M.: Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma. J Neurosurg 136(2): 378-388, Aug 2021.
1c1 Tosi, U. Jackson, C. D'Souza, Rabinowitz, M., Farrell, C., Parsel, S., Anand, V., Kacker, A., Tabaee, A., Zenonos, G., Snyderman, C., Wang, E., Evans, J., Rosen, M., Nyquist, G., Gardner, P., Schwartz, T.: Endoscopic Endonasal repair of encephloceles of the lateral sphenoid sinus: multi-institution confirmation of a new classification J Neurosurg 140(3): 705-711, Sep 2023.
137 Jackson, C., Fernandes-Cabral, D., Stefko, ST., Wang, E., Zenonos, G., Snyderman, CH., Gardner, PA.: Combined transorbital neuroendoscopic and endoscopic endonasal resection of orbital hemangioma. Neurosurgical Focus Video 16, April 2025.
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