Nathan J. Klingensmith, MD
Assistant Professor of Surgery at the Hospital of the University of Pennsylvania
Active Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Active Surgeon, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA
Active Surgeon, Pennsylvania Hospital, Philadelphia, PA
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Director of Education, Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery, University of Pennsylvania
Department: Surgery
Contact information
Penn Presbyterian Medical Center
Division of Trauma
51 N.39th Street; Mailbox 118
Philadelphia, PA 19104
Division of Trauma
51 N.39th Street; Mailbox 118
Philadelphia, PA 19104
Office: 215-662-7320
Fax: 215-243-4679
Fax: 215-243-4679
Publications
Education
BS (Biology)
Case Western Reserve University, Cleveland, OH, 2008.
MD
West Virginia University Medical School, Morgantown, WV, 2012.
Permanent linkBS (Biology)
Case Western Reserve University, Cleveland, OH, 2008.
MD
West Virginia University Medical School, Morgantown, WV, 2012.
Description of Research Expertise
Sepsis, microbiome, red blood cells, DNASelected Publications
Lee MJ, Kaplan LJ, Mohseni S, Cimino M, Kurihara H, Martinez-Casas I, Bass GA; SnapSBO Collaborators.: Impact of surgery and complications on GI recovery after SBO: Insights from the SnapSBO cohort. Colorectal Dis 2026.Klingensmith, NJ: Gut Physiology and the Microbiome. Principles of Adult Surgical Critical Care. Kaplan LJ, Martin ND, Bass GB (eds.). Springer, 2026.
Cimino MM, Bass GA, Kurihara H, Bellio G, Porta M, Cayre L, Mohseni S, Lee MJ, Kaplan LJ, Martinez-Casas I; ESTES SnapSBO Group.: Management and outcome variability in hernia-related small bowel obstruction: insights from the SnapSBO study. BJS Open 9: zraf127, Oct 2025.
Kaplan LJ, Martinez-Casas I, Mohseni S, Cimino M, Kurihara H, Lee MJ, Bass GA; SnapSBO Collaborators.: Small bowel obstruction outcomes according to compliance with the World Society of Emergency Surgery Bologna guidelines. Br J Surg 112: znaf080, Mar 2025.
Bass GA, Kaplan LJ, Gaarder C, Coimbra R, Klingensmith NJ, Kurihara H, Zago M, Cioffi SPB, Mohseni S, Sugrue M, Tolonen M, Valcarcel CR, Tilsed J, Hildebrand F, Marzi I: Publisher Correction: European Society for Trauma and Emergency Surgery member-identified research priorities in emergency surgery: A roadmap for future clinical research opportunities. European Journal of Trauma & Emergency Surgery Aug. 22 2024 (Epub) Notes: doi: 10.1007/s00068-024-02600-0.
Lam LKM, Klingensmith NJ, Sayegh L, Oatman E, Jose JS, Cosgriff CV, Eckart KA, McGinnis J, Ranjan P, Lanza M, Yehya N, Meyer NJ, Dickson RP, Mangalmurti NS.: Red blood cells capture and deliver bacterial DNA to drive host responses during polymicrobial sepsis. J Clin Invest 135: e182127, Dec 2024.
Metthew Lam LK, Oatman E, Eckart KA, Klingensmith NJ, Flowers E, Sayegh L, Yuen J, Clements RL, Meyer NJ, Jurado KA, Vaughan AE, Eisenbarth SC, Mangalmurti NS: Human red blood cells express the RNA sensor TLR7. Science Reports 14(1): 15789, July 9 2024.
Oatman E, Klingensmith N, Lam M, Eckart K, Meyer NJ, Mangalmurti NS: Human red blood cells express toll-like receptor 7 and bind single stranded RNA. American Journal of Respiratory & Critical Care Medicine 209, May 2024 Notes: Presented at the American Thoracic Society 2024 International Conference, San Diego, CA, May 2024.
Bass GA, Kaplan LJ, Gaarder C, Coimbra R, Klingensmith NJ, Kurihara H, Zago M, Cioffi SPB, Mohseni S, Sugrue M, Tolonen M, Valcarcel CR, Tilsed J, Hildebrand F, Marzi I: European Society for Trauma and Emergency Surgery member-identified research priorities in emergency surgery: A roadmap for future clinical research opportunities. European Journal of Trauma & Emergency Surgery 50(2): 367-382, Apr. 2024 Notes: Epub Feb. 27, 2024.
Paterson CW, Fay KT, Chen CW, Klingensmith NJ, Gutierrez MB, Liang Z, Coopersmith CM, Ford ML: CTLA-4 checkpoint inhibition improves sepsis survival in alcohol-exposed mice. Immunohorizons 8(1): 74-88, Jan. 1 2024.