Nathan J. Klingensmith, MD
Assistant Professor of Surgery at the Hospital of the University of Pennsylvania
Active Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Active Surgeon, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA
Active Surgeon, Pennsylvania Hospital, Philadelphia, PA
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Director of Education, Division of Traumatology, Surgical Critical Care and Emergency Surgery
Department: Surgery
Contact information
51 N.39th St
MOB building, Suite 120
Philadelphia, PA 19104
MOB building, Suite 120
Philadelphia, PA 19104
Office: 215-662-7320
Fax: 215-243-4605
Fax: 215-243-4605
Publications
Education:
BS (Biology)
Case Western Reserve University, Cleveland, OH, 2008.
MD
West Virginia University Medical School, Morgantown, WV, 2012.
Permanent linkBS (Biology)
Case Western Reserve University, Cleveland, OH, 2008.
MD
West Virginia University Medical School, Morgantown, WV, 2012.
Description of Research Expertise
Sepsis, microbiome, red blood cells, DNASelected Publications
Lam LK, Klingensmith N, Sayegh L, Oatman E, Jose J, Cosgriff C, Eckart K, McGinnis J, Ranjan P, Lanza M, Yehya N, Meyer N, Dickson R, Mangalmurti N: Red blood cell DNA capture and delivery drives host responses during polymicrobial sepsis. Research Square Apr. 23 2024 (Preprint) Notes: doi: 10.21203/rs.3.rs-2592196/v2.Bass GA, Kaplan LJ, Gaarder C, Coimbra R, Klingensmith NJ, Kurihara H, Zago M, Cioffi SPB, Mohseni S, Sugrue M, Tolonen M, Valcarcel CR, Tilsed J, Hildebrand F, Marzi I: Publisher Correction: European Society for Trauma and Emergency Surgery member-identified research priorities in emergency surgery: A roadmap for future clinical research opportunities. European Journal of Trauma & Emergency Surgery Aug. 22 2024 (Epub) Notes: doi: 10.1007/s00068-024-02600-0.
Metthew Lam LK, Oatman E, Eckart KA, Klingensmith NJ, Flowers E, Sayegh L, Yuen J, Clements RL, Meyer NJ, Jurado KA, Vaughan AE, Eisenbarth SC, Mangalmurti NS: Human red blood cells express the RNA sensor TLR7. Science Reports 14(1): 15789, July 9 2024.
Oatman E, Klingensmith N, Lam M, Eckart K, Meyer NJ, Mangalmurti NS: Human red blood cells express toll-like receptor 7 and bind single stranded RNA. American Journal of Respiratory & Critical Care Medicine 209, May 2024 Notes: Presented at the American Thoracic Society 2024 International Conference, San Diego, CA, May 2024.
Bass GA, Kaplan LJ, Gaarder C, Coimbra R, Klingensmith NJ, Kurihara H, Zago M, Cioffi SPB, Mohseni S, Sugrue M, Tolonen M, Valcarcel CR, Tilsed J, Hildebrand F, Marzi I: European Society for Trauma and Emergency Surgery member-identified research priorities in emergency surgery: A roadmap for future clinical research opportunities. European Journal of Trauma & Emergency Surgery 50(2): 367-382, Apr. 2024 Notes: Epub Feb. 27, 2024.
Paterson CW, Fay KT, Chen CW, Klingensmith NJ, Gutierrez MB, Liang Z, Coopersmith CM, Ford ML: CTLA-4 checkpoint inhibition improves sepsis survival in alcohol-exposed mice. Immunohorizons 8(1): 74-88, Jan. 1 2024.
Noorbakhsh S, Gomez L, Joung Y, Meyer C, Hanos DS, Freedberg M, Klingensmith N, Grant AA, Koganti D, Nguyen J, Smith RN, Sciarretta JD: Hepatic arterioportal fistula following liver trauma: Case series and review of the literature. Vascular & Endovascular Surgery 57(7): 749-755, Oct. 2023 Notes: Epub Mar. 20, 2023.
Oami T, Yumoto T, Shimazui T, Sarmiento S, Klingensmith NJ, Chen CW, Otani S, Liang Z, Burd EM, Mahdi ZK, Ford ML, Coopersmith CM: Chronic ethanol use worsens gut permeability and alters tight junction expression in a murine sepsis model. Shock 60(2): 280-290, Aug. 1 2023 Notes: Epub June 23, 2023.
Niziolek GM, Keating J, Bailey J, Klingensmith NJ, Moren AM, Skarupa DJ, Loria A, Vella MA, Maher Z, Moore SA, Smith MC, Leung A, Shuster KM, Seamon MJ: Rethinking protocolized completion angiography following extremity vascular trauma: A prospective observational multicenter trial. Journal of Trauma & Acute Care Surgery 95(1): 105-110, July 1 2023 Notes: Epub Apr. 11, 2023.
Lam M, Eckart KA, Klingensmith NJ, Mangalmurti NS: Deoxyribonucleic acid capture by red blood cells contributes to inflammation in sepsis. American Journal of Respiratory & Critical Care Medicine 207: 1, May 2023 Notes: Presented at the American Thoracic Society International Conference, ATS 2023, Washington, DC, May 2023.