Yanxiang Deng, PhD
Assistant Professor of Pathology and Laboratory Medicine
Associate Member , Penn Abramson Cancer Center
Core member, Penn Epigenetics Institute
Member, Penn Institute on Aging
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
422 Curie Boulevard, Stellar-Chance Laboratories 713A
Philadelphia, PA 19104
Philadelphia, PA 19104
Education:
PhD
Rensselaer Polytechnic Institute, 2018.
Permanent linkPhD
Rensselaer Polytechnic Institute, 2018.
Selected Publications
Farzad, N., Enninful, A., Bao, S., Zhang, D., Deng, Y., and Fan, R.: Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue. Nature Protocols Jun 2024.Malik, S., Pradeep, S.P., Kumar, V., Xiao, Y., Deng, Y., Fan, R., Vasquez, J.C., Singh, V., and Bahal, R: Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor. Cell Reports Medicine Jan 2024.
Deng, Y.#*, Bai, Z.#*, Fan R.*: Microtechnologies for single-cell and spatial multi-omics. Nature Reviews Bioengineering Jun 2023.
Zhang, D.#, Deng, Y.#*, Kukanja P, Agirre E, Bartosovic M, Dong M, Ma C, Ma S, Su G, Bao S, Liu Y, Xiao Y, Rosoklija GB, Dwork AJ, Mann JJ, Leong KW, Boldrini M, Wang L, Haeussler M, Raphael BJ, Kluger Y, Castelo-Branco G*, Fan R.*: Spatially resolved epigenome-transcriptome co-profiling of mammalian tissues at the cellular level. Nature Mar 2023.
Wang, Y., Malik, S., Suh, H.W., Xiao, Y., Deng, Y., Fan, R., Huttner, A., Bindra, R.S., Singh, V., Saltzman, W.M. and Bahal, R.: Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances Feb 2023.
Liu, Y., DiStasio, M., Su, G., Asashima, H., Enninful, A., Qin, X., Deng, Y., Nam, J., Gao, F., Bordignon, P., Cassano, M., Tomayko, M., Xu, M., Halene, S., Craft, J., and Fan, R.: High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq. Nature Biotechnology Feb 2023.
Deng, Y., Bartosovic, M., Ma, S., Zhang, D., Liu, Y., Qin, X., Su, G., Xu, M.L., Halene, S., Craft, J.E., Castelo-Branco, G. and Fan, R.: Spatial profiling of chromatin accessibility in mouse and human tissues. Nature 609: 375–383, Aug 2022.
Deng Y, Bartosovic M, Kukanja P, Zhang D, Liu Y, Su G, Enninful A, Bai Z, Castelo-Branco G, Fan R.: Spatial-CUT&Tag: spatially resolved chromatin modification profiling at the cellular level. Science 375: 681-686, Feb 2022.
Liu Y#, Yang M#, Deng Y#, Su G, Enninful A, Guo C, Tebaldi T, Zhang D, Kim D, Bai Z, Norris E, Pan A, Li J, Xiao Y, Halene S, Fan R.(# Co-first author): High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. Cell 183(6): 1-17, Dec 2020.
Deng Y, Finck A, and Fan R.: Single-cell omics analyses enabled by microchip technologies. Annual Review of Biomedical Engineering 21: 365-393, Jun 2019.