Blanton S Tolbert
Jacob Gershon Cohen Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Contact information
Case Western Reserve University
Department of Chemistry
10900 Euclid Ave
Cleveland, OH 44106
Department of Chemistry
10900 Euclid Ave
Cleveland, OH 44106
Office: 513.593.0039
Education:
BS (Chemistry)
University of South Carolina, 1999.
PhD (Biophysics and Structural Biology)
University of Rochester, 2006.
Permanent linkBS (Chemistry)
University of South Carolina, 1999.
PhD (Biophysics and Structural Biology)
University of Rochester, 2006.
Selected Publications
Blanton Tolbert: Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex DOI: 10.1038/s41467-023-37911-0 Apr 21 2023Mackeown M, Kung YA, Davila-Calderon J, Ford WP, Luo L, Henry B, Li ML, Brewer G, Shih SR, Tolbert BS.: The 5'UTR of HCoV-OC43 Adopts a Topologically Constrained Structure to Intrinsically Repress Translation. J Biol Chem Page: https://doi.org/10.1016/j.jbc.2023.103028 Feb 2023.
Chiu LY, Davila-Calderon J, Cai Z, Tolbert BS.: Biophysical Analysis of Small Molecule Binding to Viral RNA Structures. Methods Mol Biol 2023.
Chiu LY, Emery A, Jain N, Sugarman A, Kendrick N, Luo L, Ford W, Swanstrom R, Tolbert BS.: Encoded Conformational Dynamics of the HIV Splice Site A3 Regulatory Locus: Implications for Differential Binding of hnRNP Splicing Auxiliary Factors. J Mol Biol 434: 167728, Sep 2022.
Bevilacqua PC, Tolbert BS.: Regulatory Mechanisms through RNA Conformational Switching and Dynamics. J Mol Biol 434: 167794, Sep 2022.
Donlic A, Swanson EG, Chiu LY, Wicks SL, Juru AU, Cai Z, Kassam K, Laudeman C, Sanaba BG, Sugarman A, Han E, Tolbert BS, Hargrove AE.: R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures. ACS Chem Biol 17: 1556-1566, Jun 2022.
Basu A, Penumutchu S, Nguyen K, Mbonye U, Tolbert BS, Karn J, Komar AA, Mazumder B.: A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells. J Virol 96: e0167821, Jan 2022.
Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M, Haferlach T, Maciejewski JP, Corey SJ.: Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms. Leukemia 36: 2499-2508, 2022.
Zafferani M, Haddad C, Luo L, Davila-Calderon J, Chiu LY, Mugisha CS, Monaghan AG, Kennedy AA, Yesselman JD, Gifford RJ, Tai AW, Kutluay SB, Li ML, Brewer G, Tolbert BS, Hargrove AE.: Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures. Sci Adv 7: eabl6096, Nov 2021.
Luo L, Chiu LY, Sugarman A, Gupta P, Rouskin S, Tolbert BS.: HnRNP A1/A2 Proteins Assemble onto 7SK snRNA via Context Dependent Interactions. J Mol Biol 433: 166885, Apr 2021.