Blanton S Tolbert, PhD

faculty photo
Jacob Gershon Cohen Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics

Contact information
Department: Biochemistry and Biophysics
1009 Stellar – Chance
215 573 7972
Philadelphia, PA 19040
Office: 215 573 7972
Education:
BS (Chemistry)
University of South Carolina, 1999.
PhD (Biophysics and Structural Biology)
University of Rochester, 2006.
Permanent link
 
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Selected Publications

Blanton Tolbert: Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex DOI: 10.1038/s41467-023-37911-0 Apr 21 2023

Mackeown M, Kung YA, Davila-Calderon J, Ford WP, Luo L, Henry B, Li ML, Brewer G, Shih SR, Tolbert BS.: The 5'UTR of HCoV-OC43 Adopts a Topologically Constrained Structure to Intrinsically Repress Translation. J Biol Chem Page: https://doi.org/10.1016/j.jbc.2023.103028 Feb 2023.

Chiu LY, Davila-Calderon J, Cai Z, Tolbert BS.: Biophysical Analysis of Small Molecule Binding to Viral RNA Structures. Methods Mol Biol 2023.

Bevilacqua PC, Tolbert BS.: Regulatory Mechanisms through RNA Conformational Switching and Dynamics. J Mol Biol 434: 167794, Sep 2022.

Chiu LY, Emery A, Jain N, Sugarman A, Kendrick N, Luo L, Ford W, Swanstrom R, Tolbert BS.: Encoded Conformational Dynamics of the HIV Splice Site A3 Regulatory Locus: Implications for Differential Binding of hnRNP Splicing Auxiliary Factors. J Mol Biol 434: 167728, Sep 2022.

Donlic A, Swanson EG, Chiu LY, Wicks SL, Juru AU, Cai Z, Kassam K, Laudeman C, Sanaba BG, Sugarman A, Han E, Tolbert BS, Hargrove AE.: R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures. ACS Chem Biol 17: 1556-1566, Jun 2022.

Basu A, Penumutchu S, Nguyen K, Mbonye U, Tolbert BS, Karn J, Komar AA, Mazumder B.: A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells. J Virol 96: e0167821, Jan 2022.

Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M, Haferlach T, Maciejewski JP, Corey SJ.: Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms. Leukemia 36: 2499-2508, 2022.

Zafferani M, Haddad C, Luo L, Davila-Calderon J, Chiu LY, Mugisha CS, Monaghan AG, Kennedy AA, Yesselman JD, Gifford RJ, Tai AW, Kutluay SB, Li ML, Brewer G, Tolbert BS, Hargrove AE.: Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures. Sci Adv 7: eabl6096, Nov 2021.

Luo L, Chiu LY, Sugarman A, Gupta P, Rouskin S, Tolbert BS.: HnRNP A1/A2 Proteins Assemble onto 7SK snRNA via Context Dependent Interactions. J Mol Biol 433: 166885, Apr 2021.

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Last updated: 02/03/2025
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