Selected Publications

Derek Wong: The Clinical Impact of Multiomics Profiling in Pediatric Low-grade and High-grade Gliomas: a study of 351 gliomas from a single institution. Association for Molecular Pathology, Vancouver, Canada November 2024 Notes: Poster Presentation.

Derek Wong: Integrated multi-omics drive precision cancer care for pediatric CNS tumors: An institutional study of 582 tumors. American Society for Human Genetics, Denver, CO November 2024 Notes: Poster Presentation.

Haley Newman, Mary Egan Clark, Derek Wong, Jinhua Wu, Garrett M. Brodeur, Stephen P. Hunger, Sarah K. Tasian, Timothy Olson, Julia T. Warren, David T. Teachey, Kira Bona, Jeffrey Schubert, Netta Golenberg, Maha Patel, Elizabeth H. Denenberg, Elizabeth A. Fanning, Jiani Chen, Tamara Luke, Sarah Charles, Daniel Gallo, Kajia Cao, Weixuan Fu, Zhiqian Fan, Lea F. Surrey, Gerald Wertheim, Minjie Luo, Suzanne P. MacFarland, Marilyn M. Li, and Yiming Zhong: Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing. Hematologica 109(9): 3024-3030, September 2024.

Minjie Luo, Derek Wong, Kristin Zelley, Jinhua Wu, Jeffery Schubert, Netta Golenberg, Maha Patel, Elizabeth H Denenberg, Elizabeth A Fanning, Jiani Chen, Daniel Gallo, Tammy Luke, Sarah Charles, Kara Maxwell, Laura Conlin, Gerald B Wertheim, Lea Surrey, Yiming Zhong, Garrett M Brodeur, Suzanne P Macfarland, Marilyn M Li: Identification of TP53 germline variants in pediatric patients undergoing tumor testing: strategy and prevalence. Journal of the National Cancer Institute 116(8): 1356-1365, August 2024.

Derek Wong, Ping Luo, Vallijah Subasri, Leslie Oldfield, Haifan Gong, Nicholas Fischer, Brianne Laverty, Raymond H Kim, David Malkin, Trevor J Pugh: Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns. Nature Communications 15: 7386, August 2024 Notes: Accepted

Eric Y Stutheit-Zhao, Enrique Sanz Garcia, Zhihui Liu, Derek Wong, Kayla Marsh, Albiruni Razak, Anna Spreafico, Philippe Bedard, Aaron Hansen, Stephanie L’heureux, Dax Torti, Bernard Lam, Richard Jovelin, Lawrence Heisler, Morgan Taschuk, Cindy Yang, Justin Burgener. Scott V Bratman, Pamela Ohashi, Trevor J Pugh, Lillian L Siu: Early changes in tumor-naive cell-free methylomes and fragmentomes predict outcomes in patients with solid tumors treated with pembrolizumab. Cancer Discovery 14(6): 1048-1063, June 2024.

Derek Wong: Fragmentomic analysis of cell-free DNA reveals cancer associated signatures in TP53 mutation carriers. New Frontiers in Liquid Biopsy, DC March 2024 Notes: Poster Presentation.

Björn Brändl, Mara Steiger, Caroline Kubelt, Christian Rohrandt, Maximilian Evers, Gaojianyong Wang, Bernhard Schuldt, Martin Pröscholdt, Markus J Riemenschneider, Ulrich Schüller, Derek Wong, Amy Lum, Skarphedinn Halldorsson, Luna Djirackor, Romulas Smičius, Gelareh Zadeh, Einar O. Vik-Mo, Alexander Meissner, Ole Ammerpohl, Stephen Yip, Michael Synowitz, Alena van Boemmel, Helene Kretzmer, and Franz-Josef Müller: MethyLYZR: Live tumor diagnosis from sparse epigenomic data. Nature Medicine 2024 Notes: Accepted.

Kirsten M Farncombe, Derek Wong, Maia L Norman, Leslie E Oldfield, Mark Basik, Yvonne Bombard, Victoria Carile, Lesa Dawson, William D Foulkes, David Malkin, Aly Karsan, Patricia Parkin, Lynette S Penney, Aaron Pollett, Kasmintan A Schrader, Trevor J Pugh, Raymond H Kim on behalf of the CHARM consortium: Current and new frontiers in hereditary cancer surveillance: opportunities for liquid biopsy. The American Journal of Human Genetics 110(10): 1616-1627, October 2023.

Stephanie Lheureux, Stephenie D Prokopec, Leslie E. Oldfield, Eduardo Gonzalez-Ochoa, Jeffrey P Bruce, Derek Wong, Arnavaz Danesh, Dax Torti, Jonathan Torchia, Alexander Fortuna, Sharanjit Singh, Matthew Irving, Kayla Marsh, Bernard Lam, Ana Oaknin, Ainhoa Madariaga, Neesha C Dhani, Valerie Bowering, Amit M Oza, Trevor J Pugh: Identifying mechanisms of resistance by circulating tumour DNA in EVOLVE, a phase II trial of Cediranib plus Olaparib for ovarian cancer at time of PARP inhibitor progression. Clinical Cancer Research 29(18): 3706-3716, September 2023.