Derek Wong, Ph.D.
Assistant Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
Assistant Director of Cancer Genomics, Center for Diagnostic Innovation, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Education:
B.Sc. (General Life Science)
University of British Columbia , 2013.
Ph.D. (Pathology and Laboratory Medicine)
University of British Columbia , 2020.
Permanent linkB.Sc. (General Life Science)
University of British Columbia , 2013.
Ph.D. (Pathology and Laboratory Medicine)
University of British Columbia , 2020.
Description of Clinical Expertise
My clinical duties are within the Division of Genomic Diagnostics where I use my expertise in molecular oncology to aid in the diagnosis of pediatric tumors. I am also the Assistant Director of Cancer Genomics within the Center for Diagnostic Innovation where I lead the development and clinical validation of molecular assays for precision medicine.Description of Research Expertise
My research expertise and interests are focussed on 1) rapid tumor diagnostics using multi-modal approaches and emerging technologies and 2) leveraging the underlying tumor biology and advancements in bioinformatic technologies to extract the most information from cell-free DNA.Selected Publications
Derek Wong, Ping Luo, Leslie Oldfield, Haifan Gong, Ledia Brunga, Ron Rabinowicz, Vallijah Subasri, Clarissa Chan, Tiana Downs, Kirsten M Farncombe, Beatrice Luu, Maia Norman, Jenna Eagles, Stephenie Pederson, Johanna Wellum, Arnavaz Danesh, Stephenie Prokopec, Eric Zhao, Nadia Znassi, Bernard Lam, Kayla Marsh, Yogi Sundaravadanam, Dax Torti, David Malkin, Raymond H Kim, Trevor J Pugh.: Early Cancer Detection in Li-Fraumeni Syndrome with Cell-Free DNA. Cancer Discovery January 2024.Derek Wong, Ping Luo, Vallijah Subasri, Leslie Oldfield, Haifan Gong, Nicholas Fischer, Brianne Laverty, Raymond H Kim, David Malkin, Trevor J Pugh: Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns. Nature Communications 15: 7386, August 2024 Notes: Accepted
Eric Y Stutheit-Zhao, Enrique Sanz Garcia, Zhihui Liu, Derek Wong, Kayla Marsh, Albiruni Razak, Anna Spreafico, Philippe Bedard, Aaron Hansen, Stephanie L’heureux, Dax Torti, Bernard Lam, Richard Jovelin, Lawrence Heisler, Morgan Taschuk, Cindy Yang, Justin Burgener. Scott V Bratman, Pamela Ohashi, Trevor J Pugh, Lillian L Siu: Early changes in tumor-naive cell-free methylomes and fragmentomes predict outcomes in patients with solid tumors treated with pembrolizumab. Cancer Discovery 14(6): 1048-1063, June 2024.
Stephanie Lheureux, Stephenie D Prokopec, Leslie E. Oldfield, Eduardo Gonzalez-Ochoa, Jeffrey P Bruce, Derek Wong, Arnavaz Danesh, Dax Torti, Jonathan Torchia, Alexander Fortuna, Sharanjit Singh, Matthew Irving, Kayla Marsh, Bernard Lam, Ana Oaknin, Ainhoa Madariaga, Neesha C Dhani, Valerie Bowering, Amit M Oza, Trevor J Pugh: Identifying mechanisms of resistance by circulating tumour DNA in EVOLVE, a phase II trial of Cediranib plus Olaparib for ovarian cancer at time of PARP inhibitor progression. Clinical Cancer Research 29(18): 3706-3716, September 2023.
Kirsten M Farncombe, Derek Wong, Maia L Norman, Leslie E Oldfield, Mark Basik, Yvonne Bombard, Victoria Carile, Lesa Dawson, William D Foulkes, David Malkin, Aly Karsan, Patricia Parkin, Lynette S Penney, Aaron Pollett, Kasmintan A Schrader, Trevor J Pugh, Raymond H Kim on behalf of the CHARM consortium: Current and new frontiers in hereditary cancer surveillance: opportunities for liquid biopsy. The American Journal of Human Genetics 110(10): 1616-1627, October 2023.
Björn Brändl, Mara Steiger, Caroline Kubelt, Christian Rohrandt, Maximilian Evers, Gaojianyong Wang, Bernhard Schuldt, Martin Pröscholdt, Markus J Riemenschneider, Ulrich Schüller, Derek Wong, Amy Lum, Skarphedinn Halldorsson, Luna Djirackor, Romulas Smičius, Gelareh Zadeh, Einar O. Vik-Mo, Alexander Meissner, Ole Ammerpohl, Stephen Yip, Michael Synowitz, Alena van Boemmel, Helene Kretzmer, and Franz-Josef Müller: Rapid brain tumor classification from sparse epigenomic data. Nature Medicine March 2024.
Derek Wong: Integrated multi-omics drive precision cancer care for pediatric CNS tumors: An institutional study of 582 tumors. American Society for Human Genetics, Denver, CO November 2024 Notes: Poster Presentation.
Minjie Luo, Derek Wong, Kristin Zelley, Jinhua Wu, Jeffery Schubert, Netta Golenberg, Maha Patel, Elizabeth H Denenberg, Elizabeth A Fanning, Jiani Chen, Daniel Gallo, Tammy Luke, Sarah Charles, Kara Maxwell, Laura Conlin, Gerald B Wertheim, Lea Surrey, Yiming Zhong, Garrett M Brodeur, Suzanne P Macfarland, Marilyn M Li: Identification of TP53 germline variants in pediatric patients undergoing tumor testing: strategy and prevalence. Journal of the National Cancer Institute 116(8): 1356-1365, August 2024.
Haley Newman, Mary Egan Clark, Derek Wong, Jinhua Wu, Garrett M. Brodeur, Stephen P. Hunger, Sarah K. Tasian, Timothy Olson, Julia T. Warren, David T. Teachey, Kira Bona, Jeffrey Schubert, Netta Golenberg, Maha Patel, Elizabeth H. Denenberg, Elizabeth A. Fanning, Jiani Chen, Tamara Luke, Sarah Charles, Daniel Gallo, Kajia Cao, Weixuan Fu, Zhiqian Fan, Lea F. Surrey, Gerald Wertheim, Minjie Luo, Suzanne P. MacFarland, Marilyn M. Li, and Yiming Zhong: Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing. Hematologica 109(9): 3024-3030, September 2024.
Derek Wong, Stephen Yip: Machine Learning Classifies Cancer. Nature 555(7697): 446-447, March 2018.