Nicholas J Seewald, PhD

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Assistant Professor of Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology

Contact information
624 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
BS (Mathematics (with Life Science), cum laude)
University of Notre Dame, Notre Dame, IN, 2013.
MS (Biostatistics)
University of Michigan, Ann Arbor, MI, 2015.
MA (Statistics)
University of Michigan, Ann Arbor, MI, 2018.
PhD (Statistics)
University of Michigan, Ann Arbor, MI, 2021.
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Description of Research Expertise

Dr. Seewald is a statistician who develops and applies statistical methodology to answer key questions in public health and medicine through thoughtful study design and analysis combined with deep collaboration with applied scientists. His work is motivated by problems across a wide array of applications, including physical activity, oncology, and substance use and related policy, and spans the entire investigative process from formulating a research question through study design and data analysis.

His goal is to develop statistical methods that empower scientists to make impactful contributions in their fields. His methodological work involves building tools to address important statistical issues in a way that is accessible and understandable to applied researchers. His work is primarily related to causal inference – the use of data to make causal conclusions through precise assumptions, strong study design, and estimation techniques – with complex repeated-measures data.

Selected Publications

McGinty EE, Tormohlen KN, Seewald NJ, Bicket MC, McCourt AD, Rutkow L, White SA, Stuart EA: Effects of U.S. State Medical Cannabis Laws on Treatment of Chronic Noncancer Pain. Annals of Internal Medicine 176: 904-912, July 2023.

Seewald NJ: Adaptive Interventions for a Dynamic and Responsive Public Health Approach. American Journal of Public Health 113(1): 37-39, Jan 2023.

Smith SN, Seewald NJ, Klasnja P: Design considerations for preparation, optimization, and evaluation of digital therapeutics. Digital Therapeutics for Mental Health and Addiction: State of the Science and Vision for the Future. N. Jacobson, T. Kowatsch,and L. Marsch (eds.). Cambridge: Academic Press, Page: 135-150, Sep 2022.

Seewald NJ, Tormohlen K, McGinty B, Stuart E: Ready to roll? Practical guidance on whether and when to aggregate data in health policy evaluation. Academy Health Annual Research Meeting Jun 2022 Notes: Poster presentation.

McGinty EE, Bicket MC, Seewald NJ, Stuart EA, Alexander GC, Barry CL, McCourt AD, Rutkow L: Effects of State Opioid Prescribing Laws on Use of Opioid and Other Pain Treatments Among Commercially Insured U.S. Adults. Annals of Internal Medicine 175(5): 617-627, May 2022.

McGinty EE, Seewald NJ, Bandara S, Cerdá M, Daumit GL, Eisenberg MD, Griffin BA, Igusa T, Jackson JW, Kennedy-Hendricks A, Marsteller J, Miech EJ, Purtle J, Schmid I, Schuler MS, Yuan CT, Stuart EA: Scaling Interventions to Manage Chronic Disease: Innovative Methods at the Intersection of Health Policy Research and Implementation Science. Prevention Science 2022 Notes: doi: 10.1007/s11121-022-01427-8. Epub ahead of print.

Seewald, N.J., Hackworth, O., Almirall D. : Sequential, Multiple Assignment, Randomized Trials (SMART). In Principles and Practice of Clinical Trials. S. Piantadosi and C.L. Meinert (eds.). Springer, Cham, Page: 1-19, Aug 2021.

Seewald NJ, Kidwell KM, Nahum-Shani I, Wu T, McKay JR, Almirall D: Sample size considerations for comparing dynamic treatment regimens in a sequential multiple-assignment randomized trial with a continuous longitudinal outcome. Statistical Methods in Medical Research 29(7): 1891-1912, Jul 2020.

Seewald NJ, Smith SN, Lee AJ, Klasnja P, Murphy SA: Practical Considerations for Data Collection and Management in Mobile Health Micro-randomized Trials. Statistics in Biosciences 11(2): 355-370, Jul 2019.

Klasnja P, Smith S, Seewald NJ, Lee A, Hall K, Luers B, Hekler EB, Murphy SA: Efficacy of Contextually Tailored Suggestions for Physical Activity: A Micro-randomized Optimization Trial of HeartSteps. Annals of Behavioral Medicine 53(6): 573-582, May 2019.

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Last updated: 05/21/2024
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