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Andrey Tvardovskiy, PhD
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Assistant Professor of Biochemistry and Biophysics
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Department: Biochemistry and Biophysics
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Contact information
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Smile
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Education:
21 8 Bsc 1c (Bioengineering ) c
3a Lomonosov Moscow State University, 2011.
21 8 PhD 2f (Biochemistry and Molecular Biology) c
37 University of Southern Denmark, 2016.
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Permanent link21 8 Bsc 1c (Bioengineering ) c
3a Lomonosov Moscow State University, 2011.
21 8 PhD 2f (Biochemistry and Molecular Biology) c
37 University of Southern Denmark, 2016.
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193 Lukauskas S, Tvardovskiy A, Nguyen NV, Stadler M, Faull P, Ravnsborg T, Özdemir Aygenli B, Dornauer S, Flynn H, Lindeboom RGH, Barth TK, Brockers K, Hauck SM, Vermeulen M, Snijders AP, Müller CL, DiMaggio PA, Jensen ON, Schneider R, Bartke T.: Decoding chromatin states by proteomic profiling of nucleosome readers. Nature 2024.
11c Tvardovskiy A, Lukauskas S, Bartke T.: Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States. Epigenomics 15-16: 1061-1065, 2024 Notes: 10.1080/17501911.2024.2387527.
20f Gaggioli V, Lo CSY, Reverón-Gómez N, Jasencakova Z, Domenech H, Nguyen H, Sidoli S, Tvardovskiy A, Uruci S, Slotman JA, Chai Y, Gonçalves JGSCS, Manolika EM, Jensen ON, Wheeler D, Sridharan S, Chakrabarty S, Demmers J, Kanaar R, Groth A, Taneja N: Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability. Nat Cell Biol. doi: 10.1038/s41556-023-01167-z. Epub 2023 Jul 6 (eds.). 25(7): 2944-2959, July 2023
1a1 Weiβ M, Chanou A, Schauer T, Tvardovskiy A, Meiser S, König AC, Schmidt T, Kruse E, Ummethum H, Trauner M, Werner M, Lalonde M, Hauck SM, Scialdone A, Hamperl S.: Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control. Cell Rep 42: 112045, Feb 2023.
169 Maree JP, Tvardovskiy A, Ravnsborg T, Jensen ON, Rudenko G, Patterton HG.: Trypanosoma brucei histones are heavily modified with combinatorial post-translational modifications and mark Pol II transcription start regions with hyperacetylated H2A. Nucleic Acids Res 50: 9705-9723, Sep 2022.
17e Stolz P, Mantero AS, Tvardovskiy A, Ugur E, Wange LE, Mulholland CB, Cheng Y, Wierer M, Enard W, Schneider R, Bartke T, Leonhardt H, Elsässer SJ, Bultmann S.: TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Nucleic Acids Res 50: 8491-8511, Aug 2022.
16b Wang X, Rosikiewicz W, Sedkov Y, Mondal B, Martinez T, Kallappagoudar S, Tvardovskiy A, Bajpai R, Xu B, Pruett-Miller SM, Schneider R, Herz HM.: The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program. Life Sci Alliance 5(11):e202201572., July 2022.
166 Wang X, Rosikiewicz W, Sedkov Y, Mondal B, Martinez T, Kallappagoudar S, Tvardovskiy A, Bajpai R, Xu B, Pruett-Miller SM, Schneider R, Herz HM.: The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program. Life Sci Alliance 5: e202201572, Jul 2022.
1a8 Michl-Holzinger P, Obermeyer S, Markusch H, Pfab A, Ettner A, Bruckmann A, Babl S, Längst G, Schwartz U, Tvardovskiy A, Jensen ON, Osakabe A, Berger F, Grasser KD.: Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis. Nucleic Acids Res 50: 5014-5028, May 2022.
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Selected Publications
135 Tvardovskiy A, Lukauskas S.: Decoding the language of chromatin modifications with MARCS. Nat Rev Genet 627(10.1038/s41586-024-07141-5): 671-679, March 2024 Notes: Nat Rev Genet 2024 Oct;25(10):673-674. doi: 10.1038/s41576-024-00758-2.193 Lukauskas S, Tvardovskiy A, Nguyen NV, Stadler M, Faull P, Ravnsborg T, Özdemir Aygenli B, Dornauer S, Flynn H, Lindeboom RGH, Barth TK, Brockers K, Hauck SM, Vermeulen M, Snijders AP, Müller CL, DiMaggio PA, Jensen ON, Schneider R, Bartke T.: Decoding chromatin states by proteomic profiling of nucleosome readers. Nature 2024.
11c Tvardovskiy A, Lukauskas S, Bartke T.: Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States. Epigenomics 15-16: 1061-1065, 2024 Notes: 10.1080/17501911.2024.2387527.
20f Gaggioli V, Lo CSY, Reverón-Gómez N, Jasencakova Z, Domenech H, Nguyen H, Sidoli S, Tvardovskiy A, Uruci S, Slotman JA, Chai Y, Gonçalves JGSCS, Manolika EM, Jensen ON, Wheeler D, Sridharan S, Chakrabarty S, Demmers J, Kanaar R, Groth A, Taneja N: Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability. Nat Cell Biol. doi: 10.1038/s41556-023-01167-z. Epub 2023 Jul 6 (eds.). 25(7): 2944-2959, July 2023
1a1 Weiβ M, Chanou A, Schauer T, Tvardovskiy A, Meiser S, König AC, Schmidt T, Kruse E, Ummethum H, Trauner M, Werner M, Lalonde M, Hauck SM, Scialdone A, Hamperl S.: Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control. Cell Rep 42: 112045, Feb 2023.
169 Maree JP, Tvardovskiy A, Ravnsborg T, Jensen ON, Rudenko G, Patterton HG.: Trypanosoma brucei histones are heavily modified with combinatorial post-translational modifications and mark Pol II transcription start regions with hyperacetylated H2A. Nucleic Acids Res 50: 9705-9723, Sep 2022.
17e Stolz P, Mantero AS, Tvardovskiy A, Ugur E, Wange LE, Mulholland CB, Cheng Y, Wierer M, Enard W, Schneider R, Bartke T, Leonhardt H, Elsässer SJ, Bultmann S.: TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Nucleic Acids Res 50: 8491-8511, Aug 2022.
16b Wang X, Rosikiewicz W, Sedkov Y, Mondal B, Martinez T, Kallappagoudar S, Tvardovskiy A, Bajpai R, Xu B, Pruett-Miller SM, Schneider R, Herz HM.: The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program. Life Sci Alliance 5(11):e202201572., July 2022.
166 Wang X, Rosikiewicz W, Sedkov Y, Mondal B, Martinez T, Kallappagoudar S, Tvardovskiy A, Bajpai R, Xu B, Pruett-Miller SM, Schneider R, Herz HM.: The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program. Life Sci Alliance 5: e202201572, Jul 2022.
1a8 Michl-Holzinger P, Obermeyer S, Markusch H, Pfab A, Ettner A, Bruckmann A, Babl S, Längst G, Schwartz U, Tvardovskiy A, Jensen ON, Osakabe A, Berger F, Grasser KD.: Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis. Nucleic Acids Res 50: 5014-5028, May 2022.
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