Selected Publications

Chang CR, Vykunta VS, Goodman DB, Muldoon JJ, Nyberg WA, Liu C, Allain V, Rothrock A, Wang CH, Marson A, Shy BR, Eyquem J: Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection. bioRxiv [Preprint] Feb 2024.

Garcia J, Daniels J, Lee Y, Zhu I, Cheng K, Liu Q, Goodman D, Burnett C, Law C, Thienpont C, Alavi J, Azimi C, Montgomery G, Roybal KT, Choi J: Naturally occurring T cell mutations enhance engineered T cell therapies. Nature 626(7999): 626-634, Feb 2024.

Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A: Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell 186(19): 4216-4234, Sep 2023.

Christmas MJ, Kaplow IM, Genereux DP, Dong MX, Hughes GM, Li X, Sullivan PF, Hindle AG, Andrews G, Armstrong JC, Bianchi M, Breit AM, Diekhans M, Fanter C, Foley NM, Goodman DB, Goodman L, Keough KC, Kirilenko B, Kowalczyk A, Lawless C, Lind AL, Meadows JRS, Moreira LR, Redlich RW, Ryan L, Swofford R, Valenzuela A, Wagner F, Wallerman O, Brown AR, Damas J, Fan K, Gatesy J, Grimshaw J, Johnson J, Kozyrev SV, Lawler AJ, Marinescu VD, Morrill KM, Osmanski A, Paulat NS, Phan BN, Reilly SK, Schäffer DE, Steiner C, Supple MA, Wilder AP, Wirthlin ME, Xue JR; Zoonomia Consortium§; Birren BW, Gazal S, Hubley RM, Koepfli KP, Marques-Bonet T, Meyer WK, Nweeia M, Sabeti PC, Shapiro B, Smit AFA, Springer MS, Teeling EC, Weng Z, Hiller M, Levesque DL, Lewin HA, Murphy WJ, Navarro A, Paten B, Pollard KS, Ray DA, Ruf I, Ryder OA, Pfenning AR, Lindblad-Toh K, Karlsson EK: Evolutionary constraint and innovation across hundreds of placental mammals. Science 380(6643), Apr 2023.

Goodman DB, Azimi CS, Kearns K, Talbot A, Garakani K, Garcia J, Patel N, Hwang B, Lee D, Park E, Vykunta VS, Shy BR, Ye CJ, Eyquem J, Marson A, Bluestone JA, Roybal KT: Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Science Translational Medicine 14(670), Nov 2022.

Bucktrout SL, Banovich NE, Butterfield LH, Cimen-Bozkus C, Giles JR, Good Z, Goodman DB, Jonsson VD, Lareau C, Marson A, Maurer DM, Munson PV, Stubbington M, Taylor S, Cutchin A: Advancing T cell-based cancer therapy with single-cell technologies. Nature Medicine 28: 1761– 1764, Sep 2022.

Schubert MG, Goodman DB, Wannier TM, Kaur D, Farzadfard F, Lu TK, Shipman SL, Church GM: High-throughput functional variant screens via in vivo production of single-stranded DNA. Proceedings of the National Academy of Sciences 118(18), May 2021.

Ferreira L, Muller YD, Kaul AM, Shaikh H, Guerrero-Moreno R, Yao LE, Goodman DB, Bluestone JA, Tang Q: Chimeric antigen receptor signaling confers antitumor activity to human regulatory T cells. American Association of Immunologists May 2020.

Ferreira L, Muller YD, Kaul AM, Shaikh H, Guerrero-Moreno R, Yao LE, Goodman DB, Bluestone JA, Tang Q: Chimeric antigen receptor signaling confers antitumor activity to human regulatory T cells. American Association of Immunologists May 2020.

Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A: Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell 181(3): 728-744, Apr 2020.