Rotem Karni, PhD

Associate Professor of Genetics
Department: Genetics
Contact information
One Ucity square, floor 4, room 4018
Philadelphia, 19104
Philadelphia, 19104
Education:
BsC
The Hebrew University of Jerusalem, 1997.
Ph.D. (Biological Chemistry)
The Hebrew University of Jerusalem, Israel., 2002.
Permanent linkBsC
The Hebrew University of Jerusalem, 1997.
Ph.D. (Biological Chemistry)
The Hebrew University of Jerusalem, Israel., 2002.
Selected Publications
Yu KM, Trimble DJ, Conner CR, Sheinberg DL, Low GMI, Saluja K, Schmitt KM, Karni RJ.: Oligometastatic Parathyroid Carcinoma Presenting as Neck Pain: A Case Report. Ear Nose Throat J 102(19): 635-639, Oct 2023.Amar-Schwartz A, Cohen Y, Elhaj A, Ben-Hur V, Siegfried Z, Karni R, Dor T.: Inhibition of nonsense-mediated mRNA decay may improve stop codon read-through therapy for Duchenne muscular dystrophy. Hum Mol Genet 32(15): 2455-2463, Jul 2023.
Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R.: RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Nature 617(7959): 147-153, May 2023.
Bashari A, Siegfried Z, Karni R.: Targeting splicing factors for cancer therapy. RNA 29(4): 506-515, Apr 2023.
Amar-Schwartz A, Ben Hur V, Jbara A, Cohen Y, Barnabas GD, Arbib E, Siegfried Z, Mashahreh B, Hassouna F, Shilo A, Abu-Odeh M, Berger M, Wiener R, Aqeilan R, Geiger T, Karni R.: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair. Elife 11: e79128, Oct 2022.
Schachter NF, Adams JR, Skowron P, Kozma KJ, Lee CA, Raghuram N, Yang J, Loch AJ, Wang W, Kucharczuk A, Wright KL, Quintana RM, An Y, Dotzko D, Gorman JL, Wojtal D, Shah JS, Leon-Gomez P, Pellecchia G, Dupuy AJ, Perou CM, Ben-Porath I, Karni R, Zacksenhaus E, Woodgett JR, Done SJ, Garzia L, Sorana Morrissy A, Reimand J, Taylor MD, Egan SE.: Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer. Nat Commun 12(1): 5238, Sep 2021.
Jbara A, Siegfried Z, Karni R.: Splice-switching as cancer therapy. Curr Opin Pharmacol 59: 140-148, Aug 2021.
Hajaj E, Zisman E, Tzaban S, Merims S, Cohen J, Klein S, Frankenburg S, Sade-Feldman M, Tabach Y, Yizhak K, Navon A, Stepensky P, Hacohen N, Peretz T, Veillette A, Karni R, Eisenberg G, Lotem M.: Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions. Cancer Immunol Res 9(6): 637-650, Jun 2021.
Halperin O, Karni R, Israeli-Korn S, Hassin-Baer S, Zaidel A.: Overconfidence in visual perception in parkinson's disease. Eur J Neurosci 53(6): 2027-2039, Mar 2021.
Goldman-Wohl D, Greenfield C, Eisenberg-Loebl I, Denichenko P, Jbara A, Karni R, Ariel I, Yagel S.: Trophoblast lineage specific expression of the alternative splicing factor RBFOX2 suggests a role in placental development. Placenta 100: 142-149, Oct 2020.