Dae Hyun Lee, MD
Assistant Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
3400 Civic Center Blvd
Philadelphia, PA 19104
Philadelphia, PA 19104
Education:
MD (Premedical-Medical Combined Program)
Inha University, School of Medicine, Incheon, South Korea, 2012.
Bachelor (Statistics and Infromation)
Korean National Open University, Seoul, South Korea, 2017.
Permanent linkMD (Premedical-Medical Combined Program)
Inha University, School of Medicine, Incheon, South Korea, 2012.
Bachelor (Statistics and Infromation)
Korean National Open University, Seoul, South Korea, 2017.
Description of Clinical Expertise
My clinical expertise is in improving cardiovascular health for cancer patients and survivors with cardiovascular risk factors, cardiovascular disease, or cardiotoxicity. I work alongside world-class experts in Thalheimer Center for Cardio-OncologyDescription of Research Expertise
The aim of my research is to improve cardiovascular health for cancer patients and survivors. My research interest includes investigating clonal hematopoiesis of indeterminate potential (CHIP) as a mechanism and therapeutic target for cardiovascular health in patients with cancer. I have special expertise in cardiotoxicity in patients undergoing cellular immunotherapy.Selected Publications
Palfi S, Peres LC, Koelmeyer H, Alsina M, Baz RC, Blue BJ, Corallo S, De Avila G, Freeman C, Gonzalez R, Grajales-Cruz A, Harvey K, Liu HD, Nishihori T, Oliveira GH, Oswald LB, Castaneda Puglianini O, Selvakumar S, Sharma AB, Wang E, Shain KH, Jain M, Locke FL, Alomar M, Hansen DK, Lee DH.: Cardiovascular adverse events and outcomes after anti-BCMA CAR-T for relapsed and refractory multiple myeloma. Blood Cancer J 15(1): 63, Apr 2025.Hesterberg RS, Davis JT, Handoo KJ, Elmarsafawi AG, Augello AC, Cheng CH, Atkins R, Lee DH, Yang C, Yao J, Patel KR, Mediavilla-Varela M, Pinilla-Ibarz J, Soto-Palma C, Locke FL, Song X, Wang X, Berglund AE, Rodriguez PC, Knittel G, Flümann R, Reinhardt HC, Shaw TI, Yu X, Niedernhofer LJ, Cleveland JL.: Lymphoma accelerates T cell and tissue aging. Cancer Cell Aug 2025.
Vincellette ND, Yu X, Kuykendall AT, Moon J, Su S, Cheng CH, Sammut R, Razabdouski TN, Nguyen HV, Eksioglu EA, Chan O, Ali NA, Patel PC, Lee DH, Nakanishi S, Ferreira RB, Mo Q, Cory S, Lawrence HR, Zhang L, Murphy DJ, Komrokji RS, Lee D, Kaufmann SH, Cleveland JL, Yun S.: Trisomy 8 Defines a Distinct Subtype of Myeloproliferative Neoplasms Driven by the MYC-Alarmin Axis. Blood Cancer Discov 5(4): 276-297, Jul 2024.
C Scoma, DH Lee, DB Money, GS Eichelberger, A Usmani, AJ Cohen, J Fernandez.: The Impact of Midodrine on Guideline-Directed Medical Therapy in Patients Admitted With Systolic Heart Failure. J Cardiovasc Pharmacol 83(4): 353-358, Apr 2024.
Lee DH, Usmani A, Wu R, Wicks T, Noh CY, Burke R, Ravichandran V, Wolf-Doty T, Dumitru I, Oliveira GH, Berman P, Mackie B.: Relationship between donor-derived cell-free DNA and tissue-based rejection-related transcripts in heart transplantation. J Heart Lung Transplant Jul 2024.
Lee DH, Usmani A, Ravichandran V, Wicks T, Wu R, Wolf-Doty T, Dumitru I, Berman P, Oliveira GH, Mackie B.: Relationship between blood and tissue-based rejection-related transcripts in heart transplantation. J Heart Lung Transplant 43(3): 359-368, Mar 2024.
DH Lee, A Kumar, T Mohammed, LC Peres, M Alsina, C Bachmeier, BJ Blue, J Brayer, S Chandrasekhar, A Grajales Cruz, G De Avila, H Elmariah, R Faramand, C Freeman, M Jain, S Khadka, F Khimani, H Liu, T Nishihori, LB Oswald, OA Casteneda Puglianini, KH Shain, E Smith, RC Baz, FL Locke, GH Oliveira, M Alomar, DK Hansen.: Cardiac events after standard of care idecabtagene vicleucel for relapsed and refractory multiple myeloma. Blood Adv 7(16): 4247-4257, Aug 2023.
DH Lee, S Chandrasekhar, MD Jain, R Mhaskar, K Reid, SB Lee, S Corallo, MJ Hidalgo-Vargas, A Kumar, J Chavez, B Shah, A Lazaryan, F Khimani, T Nishihori, C Bachmeier, R Faramand, MG Fradley, D Jeong, GH Oliveira, FL Locke, ML Davila, M Alomar.: Cardiac and inflammatory biomarker differences in adverse cardiac events after chimeric antigen receptor T-Cell therapy: an exploratory study. Cardio-oncology 9(1): doi: 10.1186, Apr 2023.
DH Lee, F Hawk, K Seok, M Gliksman, J Emole, IB Rhea, F Viganego, A Welter-Frost, M Armanious, B Shah, JC Chavez, J Pinilla-Ibarz, MB Schabath, M Fradley.: Association between ibrutinib treatment and hypertension. Heart 108(6): 445-450, Mar 2022.
RM Alvi, MJ Frigault, MG Fradley, MD Jain, SS Mahmood, M Awadalla, DH Lee, DA Zlotoff, L Zhang, ZD Drobni, MZO Hassan, E Bassily, I Rhea, R Ismail-Khan, CP Mulligan, D Banerji, A Lazaryan, BD Shah, A Rokicki, N Raje, JC Chavez, J Abramson, FL Locke, TG Neilan.: Cardiovascular Events Among Adults Treated With Chimeric Antigen Receptor T-Cells (CAR-T). J Am Coll Cardiol 74(25): 3099-3108, Dec 2019.