Mark D Zarella
Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact information
Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
6 Founders Pavilion
Philadelphia, PA 19104
Department of Pathology and Laboratory Medicine
6 Founders Pavilion
Philadelphia, PA 19104
Education:
B.S. (Physics)
University of Massachusetts, 2002.
Ph.D. (Neuroscience )
State University of New York – Upstate Medical University, Syracuse, NY, 2011.
Permanent linkB.S. (Physics)
University of Massachusetts, 2002.
Ph.D. (Neuroscience )
State University of New York – Upstate Medical University, Syracuse, NY, 2011.
Selected Publications
Sumpena, E., Tavolara, T. E., Zarella, M. D., & Han, W.: Region of interest detection on breast immunohistochemistry images for end-to-end Ki-67 biomarker quantification. SPIE 13413: 91-95, April 2025 Notes: https://doi.org/10.1117/12.3046242.M Francis, M Zarella: 1351 Size Normalization Using Oversampling for Improving AI Generalizability Across Slide Scanners. Laboratory Investigation 105(3): 103589, March 2025.
M Francis, M Zarella: 1352 A Computational Framework for Bulk Annotating OCT Images Using Deep Learning. Laboratory Investigation 105(3): 103590, March 2025.
W Han, T Tavolara, M Zarella: 1550 FROG: An Unsupervised Deep Learning Framework for Scalable, Robust, and Generalizable End-to-end IHC Quantification. Laboratory Investigation 105(3): 103792, March 2025.
D Macaulay, M Jones, M Francis, F Garcia, M Zarella: 1809 Automated Whole-Slide Image Tissue Capture Assessment Using a Convolutional Neural Network. Laboratory Investigation 105(3), March 2025.
R Simonson, M Zarella: 1384 PHI Can Be Present in Whole-slide Images After Conventional Deidentification Methods are Applied. Laboratory Investigation 105(3): 103622, March 2025.
Macaulay DO, Han W, Zarella MD, Garcia CA, Tavolara TE.: Enhancing HER2 testing in breast cancer: predicting fluorescence in situ hybridization (FISH) scores from immunohistochemistry images via deep learning. J Pathol Clin Res. 11(2): e70024, March 2025 Notes: doi: 10.1002/2056-4538.70024. PMID: 40050230; PMCID: PMC11884934.
Hanna MG, Olson NH, Zarella M, Dash RC, Herrmann MD, Furtado LV, Stram MN, Raciti PM, Hassell L, Mays A, Pantanowitz L, Sirintrapun JS, Krishnamurthy S, Parwani A, Lujan G, Evans A, Glassy EF, Bui MM, Singh R, Souers RJ, de Baca ME, Seheult JN.: Recommendations for Performance Evaluation of Machine Learning in Pathology: A Concept Paper From the College of American Pathologists. Arch Pathol Lab Med. 148(10): e335-e361, October 2024 Notes: doi: 10.5858/arpa.2023-0042-CP.
Zarella MD. : Mentoring Mondays. Association for Pathology Informatics (API) September 9 2024.
Molnar, C., Tavolara, T. E., Garcia, C. A., McClintock, D. S., Zarella, M. D., & Han, W.: IHCScoreGAN: An unsupervised generative adversarial network for end-to-end Ki67 scoring for clinical breast cancer diagnosis. Proceedings of The 7th International Conference on Medical Imaging with Deep Learning 250(no issue): 1011-1025, July 2024.