Selected Publications

Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C.: Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes. Nature Chemical Biology 21(7): 1046-1057, July 2025.

Mishra S, Yadav MK, Dalal A, Ganguly M, Yadav R, Sawada K, Tiwari D, Roy N, Banerjee N, Fung JN, Marallag J, Cui CS, Li XX, Lee JD, Dsouza CA, Saha S, Sarma P, Rawat G, Zhu H, Khant HA, Clark RJ, Sano FK, Banerjee R, Woodruff TM, Nureki O, Gati C, Shukla AK.: Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors. bioRxiv May 2025 Notes: Preprint.

Yadav R, Han GW, Gati C.: Molecular basis of human GABA transporter 3 inhibition. Nature communications 16(1): 3830, Apr 2025.

Posa L, Romano G, Ji X, Khan S, Paz BM, Han GW, Nazarova AL, Zaidi SA, Ranjbar M, Pleil K, Katritch V, Gati C, Trauner D, Levitz J.: An opioid efficacy switch for reversible optical control of peripheral analgesia. bioRxiv Feb 2025 Notes: Preprint.

Yadav R, Gati C.: Packaging monoamine neurotransmitters. Cell Research 34(3): 185-186, Mar 2024.

Stefanski A, Pérez-Palma E, Brünger T, Montanucci L, Gati C, Klöckner C, Johannesen KM, Goodspeed K, Macnee M, Deng AT, Aledo-Serrano Á, Borovikov A, Kava M, Bouman AM, Hajianpour MJ, Pal DK, Engelen M, Hagebeuk EEO, Shinawi M, Heidlebaugh AR, Oetjens K, Hoffman TL, Striano P, Freed AS, Futtrup L, Balslev T, Abulí A, Danvoye L, Lederer D, Balci T, Nouri MN, Butler E, Drewes S, van Engelen K, Howell KB, Khoury J, May P, Trinidad M, Froelich S, Lemke JR, Tiller J, Freed AN, Kang JQ, Wuster A, Møller RS, Lal D.: SLC6A1 variant pathogenicity, molecular function and phenotype: a genetic and clinical analysis. Brain: a journal of neurology 146(12): 5198-5208, Dec 2023.

Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C.: Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell 186(22): 4956-4973, Oct 2023.

Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC.: Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell 186(19): 4189-4203, Sep 2023.

Khan S, Gati C.: Decoding the mechanisms of allostery. eLife 12: e88749, June 2023.

Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C.: Structural basis of GABA reuptake inhibition. Nature 608(E15): 820-826, August 2022.