John A. Detre

faculty photo
Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
3 W Gates Building
3400 Spruce Street
Office: 517 Goddard Labs
Philadelphia, PA 19104
Office: (215) 349-8465
Fax: (215) 614-1927
B.S. (Chemistry)
Yale University , 1981.
Yale University, 1986.
Permanent link
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Description of Research Expertise

magnetic resonance, brain mapping, cerebral blood flow, brain injury

Brain physiology and pathophysiology of functional activation. Clinical and translational neuroimaging.

Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.

Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, epilepsy, traumatic brain injury, aging, and dementia. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods.

Description of Clinical Expertise

headache, facial pain syndromes, stroke

Selected Publications

Adebimpe, A., Bertolero, M., Dolui, S., Cieslak, M., Murtha, K., Baller, E. B., Boeve, B., Boxer, A., Butler, E. R., Cook, P., Colcombe, S., Covitz, S., Davatzikos, C., Davila, D. G., Elliott, M. A., Flounders, M. W., Franco, A. R., Gur, R. E., Gur, R. C., Jaber, B., McMillian, C., Allftd Consortium, Milham, M., Mutsaerts, Hjmm, Oathes, D. J., Olm, C. A., Phillips, J. S., Tackett, W., Roalf, D. R., Rosen, H., Tapera, T. M., Tisdall, M. D., Zhou, D., Esteban, O., Poldrack, R. A., Detre, J. A., Satterthwaite, T. D.: ASLPrep: a platform for processing of arterial spin labeled MRI and quantification of regional brain perfusion. Nat Methods 19(6): 683-686, 2022.

Kim, W. S. H., Luciw, N. J., Atwi, S., Shirzadi, Z., Dolui, S., Detre, J. A., Nasrallah, I. M., Swardfager, W., Bryan, R. N., Launer, L. J., MacIntosh, B. J.: Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: A coronary artery risk development in young adults magnetic resonance imaging substudy. Hum Brain Mapp 43(12): 3680-3693, 2022.

Jacobs, P. S., Benyard, B., Cember, A., Nanga, R. P. R., Cao, Q., Tisdall, M. D., Wilson, N., Das, S., Davis, K. A., Detre, J., Roalf, D., Reddy, R.: Repeatability of B1 (+) inhomogeneity correction of volumetric (3D) glutamate CEST via High-permittivity dielectric padding at 7T. Magn Reson Med 88(6): 2475-2484, 2022.

Hu, F., Weinstein, S. M., Baller, E. B., Valcarcel, A. M., Adebimpe, A., Raznahan, A., Roalf, D. R., Robert-Fitzgerald, T. E., Gonzenbach, V., Gur, R. C., Gur, R. E., Vandekar, S., Detre, J. A., Linn, K. A., Alexander-Bloch, A., Satterthwaite, T. D., Shinohara, R. T.: Voxel-wise intermodal coupling analysis of two or more modalities using local covariance decomposition. Hum Brain Mapp 43(15): 4650-4663, 2022.

Dolui, S., Detre, J. A., Gaussoin, S. A., Herrick, J. S., Wang, D. J. J., Tamura, M. K., Cho, M. E., Haley, W. E., Launer, L. J., Punzi, H. A., Rastogi, A., Still, C. H., Weiner, D. E., Wright, J. T., Jr., Williamson, J. D., Wright, C. B., Bryan, R. N., Bress, A. P., Pajewski, N. M., Nasrallah, I. M.: Association of Intensive vs Standard Blood Pressure Control With Cerebral Blood Flow: Secondary Analysis of the SPRINT MIND Randomized Clinical Trial. JAMA Neurol 79(4): 380-389, 2022.

Jiang, H., Simms, A. G., Sadaghiani, S., Jiang, Y. Y., Morgan, J. I. W., Aguirre, G. K., Pattany, P. M., Detre, J. A., Wang, J.: Multi-Center Repeatability of Macular Capillary Perfusion Density Using Optical Coherence Tomography Angiography. Clin Ophthalmol 16: 3069-3078, 2022.

Clement, P., Castellaro, M., Okell, T. W., Thomas, D. L., Vandemaele, P., Elgayar, S., Oliver-Taylor, A., Kirk, T., Woods, J. G., Vos, S. B., Kuijer, J. P. A., Achten, E., van Osch, M. J. P., Bids maintainers, Detre, J. A., Lu, H., Alsop, D. C., Chappell, M. A., Hernandez-Garcia, L., Petr, J., Mutsaerts, Hjmm: ASL-BIDS, the brain imaging data structure extension for arterial spin labeling. Sci Data 9(1): 543, 2022.

Cember, A. T. J., Wilson, N. E., Rich, L. J., Bagga, P., Nanga, R. P. R., Swago, S., Swain, A., Thakuri, D., Elliot, M., Schnall, M. D., Detre, J. A., Reddy, R.: Integrating (1)H MRS and deuterium labeled glucose for mapping the dynamics of neural metabolism in humans. Neuroimage 251: 118977, 2022.

Bouhrara, M., Triebswetter, C., Kiely, M., Bilgel, M., Dolui, S., Erus, G., Meirelles, O., Bryan, N. R., Detre, J. A., Launer, L. J.: Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Netw Open 5(9): e2231189, 2022.

Baller, E. B., Valcarcel, A. M., Adebimpe, A., Alexander-Bloch, A., Cui, Z., Gur, R. C., Gur, R. E., Larsen, B. L., Linn, K. A., O'Donnell, C. M., Pines, A. R., Raznahan, A., Roalf, D. R., Sydnor, V. J., Tapera, T. M., Tisdall, M. D., Vandekar, S., Xia, C. H., Detre, J. A., Shinohara, R. T., Satterthwaite, T. D.: Developmental coupling of cerebral blood flow and fMRI fluctuations in youth. Cell Rep 38(13): 110576, 2022.

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Last updated: 10/25/2022
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