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Iain Mathieson, Ph.D.
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Associate Professor of Genetics
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Department: Genetics
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Graduate Group Affiliations
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Contact information
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405A Clinical Research Building
3b 415 Curie Boulevard
Philadelphia, PA 19104-6145
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3b 415 Curie Boulevard
Philadelphia, PA 19104-6145
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Office: 215-573-1835
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Email:
mathi@upenn.edu
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mathi@upenn.edu
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Education:
21 7 BA 18 (Mathematics) c
2d Cambridge University, 2005.
21 a MPhil 20 (Statistical Science) c
2d Cambridge University, 2006.
21 a DPhil 2a (Genomic Medicine & Statistics) c
2a Oxford University, 2013.
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Permanent link21 7 BA 18 (Mathematics) c
2d Cambridge University, 2005.
21 a MPhil 20 (Statistical Science) c
2d Cambridge University, 2006.
21 a DPhil 2a (Genomic Medicine & Statistics) c
2a Oxford University, 2013.
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ce Skoglund P, Mathieson I: Genomic insights into natural selection in recent human history. Nature Reviews Genetics (In revision) 2026.
9b Flint J, Mathieson I: What's in the junk? London Review of Books 47(21), Nov 2025.
207 Cox SL, Kaymak-Loveless K, Shin C, Alihodžić T, Alt KW, Atanassova N, Binder D, Čaušević-Bully M, Chohadzhiev A, Chohadzhiev S, Duday H, Gaydarska B, Khudaverdyan A, Micó Perez R, Nicklisch N, Novak M, Oliart Caravatti C, Réveillas H, Rivollat M, Rottier S, Tončinić D, Zäuner S, Mathieson I: Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans. Current Biology 35(22): 5654-5665, Nov 2025.
11a Aw AJ, Mandla R, Shi Z; Penn Medicine Biobank; Pasaniuc B, Mathieson I.: Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations. Genetics Oct 2025.
c0 Mathieson I.: Polygenic prediction of human complex traits using ancient DNA. Curr Opin Genet Dev 95: 102396, Aug 2025.
183 Mies G, Tsao NL, Houy A, Coupland SE, Kalirai H, Försti A, Hemminki K, Thomsen H, Stern MH, Shields CL, Damrauer SM, Ewens KG, Ganguly A, Mathieson I.: Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity. HGG Adv 6: 100465, Jul 2025.
12a Ramos-Almodóvar F, Gao Z, Voight BF, Mathieson I.: Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes. bioRxiv (In revision PNAS) Page: doi: 10.1101/2025.05.28.656604, May 2025.
152 Barton AR, Santander CG, Skoglund P, Moltke I, Reich D, Mathieson I.: Insufficient evidence for natural selection associated with the Black Death. Nature Page: :E19-E22, Feb 2025 Notes: This is a peer-reviewed technical comment on a previously published manuscript.
10f Tchatchoua DT, Mathieson I, Zhebentyayeva T, Poethig RS, Carlson JE : Sources of Genetic Variation in Faidherbia albida (Del.) A. Chev. Sub-Saharan African Populations. Forests 16(1): 113, Jan 2025.
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Selected Publications
ff Mathieson I: [Book Chapter] Population Structure, history and Evolution. In: Vogel and Motulsky's Human Genetics (5th ed.). Morton C, Antonarakis S (eds.). Springer, To Appear 2026.ce Skoglund P, Mathieson I: Genomic insights into natural selection in recent human history. Nature Reviews Genetics (In revision) 2026.
9b Flint J, Mathieson I: What's in the junk? London Review of Books 47(21), Nov 2025.
207 Cox SL, Kaymak-Loveless K, Shin C, Alihodžić T, Alt KW, Atanassova N, Binder D, Čaušević-Bully M, Chohadzhiev A, Chohadzhiev S, Duday H, Gaydarska B, Khudaverdyan A, Micó Perez R, Nicklisch N, Novak M, Oliart Caravatti C, Réveillas H, Rivollat M, Rottier S, Tončinić D, Zäuner S, Mathieson I: Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans. Current Biology 35(22): 5654-5665, Nov 2025.
11a Aw AJ, Mandla R, Shi Z; Penn Medicine Biobank; Pasaniuc B, Mathieson I.: Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations. Genetics Oct 2025.
c0 Mathieson I.: Polygenic prediction of human complex traits using ancient DNA. Curr Opin Genet Dev 95: 102396, Aug 2025.
183 Mies G, Tsao NL, Houy A, Coupland SE, Kalirai H, Försti A, Hemminki K, Thomsen H, Stern MH, Shields CL, Damrauer SM, Ewens KG, Ganguly A, Mathieson I.: Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity. HGG Adv 6: 100465, Jul 2025.
12a Ramos-Almodóvar F, Gao Z, Voight BF, Mathieson I.: Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes. bioRxiv (In revision PNAS) Page: doi: 10.1101/2025.05.28.656604, May 2025.
152 Barton AR, Santander CG, Skoglund P, Moltke I, Reich D, Mathieson I.: Insufficient evidence for natural selection associated with the Black Death. Nature Page: :E19-E22, Feb 2025 Notes: This is a peer-reviewed technical comment on a previously published manuscript.
10f Tchatchoua DT, Mathieson I, Zhebentyayeva T, Poethig RS, Carlson JE : Sources of Genetic Variation in Faidherbia albida (Del.) A. Chev. Sub-Saharan African Populations. Forests 16(1): 113, Jan 2025.
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