Selected Publications

Stieg, D.C., Casey, K., Karisetty, B.C., Leu, J.I., Larkin, F., Vogel, P., Madzo, J., Murphy, M.E.: The Ashkenazi-Centric G334R Variant of TP53 is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model. Mol Cell Biol. 8: 1-15, 2024.

IGVF Consortium: Deciphering the impact of genomic variation on function. Nature 633: 47-57, 2024.

Indeglia, A., Leung, J.C., Miller, S.A., Leu, J.I., Dougherty, J.F., Clarke, N.L., Kirven, N.A., Shao, C., Ke, L., Lovell, S., Barnoud, T., Lu, D.Y., Lin, C., Kannan, T., Battaile, K.P., Yang, T.H.L., Batista Oliva, I., Claiborne, D.T., Vogel, P., Liu, L., Liu, Q., Nefedova, Y., Cassel, J., Auslander, N., Kossenkov, A.V., Karanicolas, J., Murphy, M.E.: An African-specific variant of TP53 reveals PADI4 as a regulator of p53-mediated tumor suppression. Cancer Discovery 13(7): 1696-1719, 2023.

Leung, J.C., Leu, J.I., Indeglia, A., Kannan, T., Clarke, N.L., Kirven, N.A., Dweep, H., Garlick, D., Barnoud, T., Kossenkov, A.V., George, D.L., Murphy, M.E.: Common activities and predictive gene signature identified for genetic hypomorphs of TP53. Proc. Natl. Acad. Sci. USA. 120(7): e2212940120, 2023.

Leu, J.I., Murphy, M.E., George, D.L.: Targeting ErbB3 and Cellular NADPH/NADP+ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers. ACS Chemical Biology 17(5): 1038-1044, 2022.

Leu, J.I., Murphy, M.E., George, D.L.: P53 regulates cellular redox state, ferroptosis and metabolism. Molecular & Cellular Oncology 8(2): 1877076, 2021.

Parris, J.L.D., Barnoud, T., Leu, J.I., Leung, J.C., Ma, W., Kirven, N.A., Poli, A.N.R., Kossenkov, A.V., Liu, Q., Salvino, J.M., George, D.L., Weeraratna, A.T., Chen, Q., Murphy, M.E.: HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS mutant melanoma. Cancer Research Communications. 1: 17-29, 2021.

Singh, K.S., Leu*, J.I., Barnoud, T., Vonteddu, P., Gnanapradeepan, K., Lin, C., Liu, Q., Barton, J.C., Kossenkov, A.V., George, D.L., Murphy, M.E., Dotiwala, F.: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Nature Communications 11(1): 473, 2020. Notes: *Co-first author.

Leu, J.I., Murphy, M.E., George, D.L.: Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53. Proc. Natl. Acad. Sci. USA. 117(43): 26804-26811, 2020.

Barnoud, T., Leung*, J.C., Leu*, J.I., Basu*, S., Poli*, A.N.R., Parris, J.L.D., Indeglia, A., Martynyuk, T., Good, M., Gnanapradeepan, K., Sanseviero, E., Moeller, R., Tang, H.Y., Cassel, J., Kossenkov, A.V., Liu, Q., Speicher, D.W., Gabrilovich, D.I., Salvino, J.M., George, D.L., Murphy, M.E.: A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors. Cancer Research. 80(23): 5270-5281, 2020. Notes: *Equal contribution.

Gnanapradeepan, K., Leu, J.I., Basu, S., Barnoud, T., Good, M., Lee, J.V., Quinn, W.J., Kung, C.P., Ahima, R., Baur, J.A., Wellen, K.E., Liu, Q., Schug, Z.T., George, D.L., Murphy, M.E.: Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser. Elife 9: e55994, 2020.