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Julia I-Ju Leu, PhD
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Research Associate Professor of Genetics
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Department: Genetics
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Contact information
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Perelman School of Medicine, University of Pennsylvania
1e Department of Genetics
28 540-5 Clinical Research Building
31 415 Curie Blvd
Philadelphia, PA 19104
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1e Department of Genetics
28 540-5 Clinical Research Building
31 415 Curie Blvd
Philadelphia, PA 19104
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Office: 215-898-5033
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Email:
leu@pennmedicine.upenn.edu
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leu@pennmedicine.upenn.edu
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Education:
21 9 B.S. 27 (Cell and Molecular Biology) c
31 University of Washington, 1994.
21 a Ph.D. 27 (Cell and Molecular Biology) c
34 University of Pennsylvania , 2001.
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Permanent link21 9 B.S. 27 (Cell and Molecular Biology) c
31 University of Washington, 1994.
21 a Ph.D. 27 (Cell and Molecular Biology) c
34 University of Pennsylvania , 2001.
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15f Stieg, D.C., Casey, K., Karisetty, B.C., Leu, J.I., Larkin, F., Vogel, P., Madzo, J., Murphy, M.E.: The Ashkenazi-centric G334R variant of TP53 is severely impaired for transactivation but retains tumor suppressor function in a mouse model. Mol Cell Biol. 44(12): 607-621, 2024.
b1 IGVF Consortium: Deciphering the impact of genomic variation on function. Nature 633(8028): 47-57, 2024.
238 Indeglia, A., Leung, J.C., Miller, S.A., Leu, J.I., Dougherty, J.F., Clarke, N.L., Kirven, N.A., Shao, C., Ke, L., Lovell, S., Barnoud, T., Lu, D.Y., Lin, C., Kannan, T., Battaile, K.P., Yang, T.H.L., Batista Oliva, I., Claiborne, D.T., Vogel, P., Liu, L., Liu, Q., Nefedova, Y., Cassel, J., Auslander, N., Kossenkov, A.V., Karanicolas, J., Murphy, M.E.: An African-specific variant of TP53 reveals PADI4 as a regulator of p53-mediated tumor suppression. Cancer Discovery 13(7): 1696-1719, 2023.
17a Leung, J.C., Leu, J.I., Indeglia, A., Kannan, T., Clarke, N.L., Kirven, N.A., Dweep, H., Garlick, D., Barnoud, T., Kossenkov, A.V., George, D.L., Murphy, M.E.: Common activities and predictive gene signature identified for genetic hypomorphs of TP53. Proc. Natl. Acad. Sci. USA. 120(7): e2212940120, 2023.
109 Leu, J.I., Murphy, M.E., George, D.L.: Targeting ErbB3 and cellular NADPH/NADP(+) abundance sensitizes cutaneous melanomas to ferroptosis inducers. ACS Chemical Biology 17(5): 1038-1044, 2022.
e2 Leu, J.I., Murphy, M.E., George, D.L.: P53 regulates cellular redox state, ferroptosis and metabolism. Molecular & Cellular Oncology 8(2): 1877076, 2021.
1b3 Parris, J.L.D., Barnoud, T., Leu, J.I., Leung, J.C., Ma, W., Kirven, N.A., Poli, A.N.R., Kossenkov, A.V., Liu, Q., Salvino, J.M., George, D.L., Weeraratna, A.T., Chen, Q., Murphy, M.E.: HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma. Cancer Research Communications. 1(1): 17-29, Oct 2021.
1a8 Singh, K.S., Leu*, J.I., Barnoud, T., Vonteddu, P., Gnanapradeepan, K., Lin, C., Liu, Q., Barton, J.C., Kossenkov, A.V., George, D.L., Murphy, M.E., Dotiwala, F.: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Nature Communications 11(1): 473, 2020. Notes: *Co-first author.
122 Leu, J.I., Murphy, M.E., George, D.L.: Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53. Proc. Natl. Acad. Sci. USA. 117(43): 26804-26811, 2020.
218 Barnoud, T., Leung*, J.C., Leu*, J.I., Basu*, S., Poli*, A.N.R., Parris, J.L.D., Indeglia, A., Martynyuk, T., Good, M., Gnanapradeepan, K., Sanseviero, E., Moeller, R., Tang, H.Y., Cassel, J., Kossenkov, A.V., Liu, Q., Speicher, D.W., Gabrilovich, D.I., Salvino, J.M., George, D.L., Murphy, M.E.: A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors. Cancer Research. 80(23): 5270-5281, 2020. Notes: *Equal contribution.
1ac Gnanapradeepan, K., Leu, J.I., Basu, S., Barnoud, T., Good, M., Lee, J.V., Quinn, W.J., Kung, C.P., Ahima, R., Baur, J.A., Wellen, K.E., Liu, Q., Schug, Z.T., George, D.L., Murphy, M.E.: Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser. Elife 9: e55994, 2020.
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Selected Publications
1a7 Shao, C., Indeglia, A., Foster, M., Casey, K., Leung, J., Modarai, S.R., Leu, J.I., Doung, B., Mes-Masson, A.M., Sims-Mourtada, J., Auslander, N., Drapkin, R., Bitler, B.G., Zhang, N., Murphy, M.E.: Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer. Genes & Development. 40(3-4): 199-214, 2026.15f Stieg, D.C., Casey, K., Karisetty, B.C., Leu, J.I., Larkin, F., Vogel, P., Madzo, J., Murphy, M.E.: The Ashkenazi-centric G334R variant of TP53 is severely impaired for transactivation but retains tumor suppressor function in a mouse model. Mol Cell Biol. 44(12): 607-621, 2024.
b1 IGVF Consortium: Deciphering the impact of genomic variation on function. Nature 633(8028): 47-57, 2024.
238 Indeglia, A., Leung, J.C., Miller, S.A., Leu, J.I., Dougherty, J.F., Clarke, N.L., Kirven, N.A., Shao, C., Ke, L., Lovell, S., Barnoud, T., Lu, D.Y., Lin, C., Kannan, T., Battaile, K.P., Yang, T.H.L., Batista Oliva, I., Claiborne, D.T., Vogel, P., Liu, L., Liu, Q., Nefedova, Y., Cassel, J., Auslander, N., Kossenkov, A.V., Karanicolas, J., Murphy, M.E.: An African-specific variant of TP53 reveals PADI4 as a regulator of p53-mediated tumor suppression. Cancer Discovery 13(7): 1696-1719, 2023.
17a Leung, J.C., Leu, J.I., Indeglia, A., Kannan, T., Clarke, N.L., Kirven, N.A., Dweep, H., Garlick, D., Barnoud, T., Kossenkov, A.V., George, D.L., Murphy, M.E.: Common activities and predictive gene signature identified for genetic hypomorphs of TP53. Proc. Natl. Acad. Sci. USA. 120(7): e2212940120, 2023.
109 Leu, J.I., Murphy, M.E., George, D.L.: Targeting ErbB3 and cellular NADPH/NADP(+) abundance sensitizes cutaneous melanomas to ferroptosis inducers. ACS Chemical Biology 17(5): 1038-1044, 2022.
e2 Leu, J.I., Murphy, M.E., George, D.L.: P53 regulates cellular redox state, ferroptosis and metabolism. Molecular & Cellular Oncology 8(2): 1877076, 2021.
1b3 Parris, J.L.D., Barnoud, T., Leu, J.I., Leung, J.C., Ma, W., Kirven, N.A., Poli, A.N.R., Kossenkov, A.V., Liu, Q., Salvino, J.M., George, D.L., Weeraratna, A.T., Chen, Q., Murphy, M.E.: HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma. Cancer Research Communications. 1(1): 17-29, Oct 2021.
1a8 Singh, K.S., Leu*, J.I., Barnoud, T., Vonteddu, P., Gnanapradeepan, K., Lin, C., Liu, Q., Barton, J.C., Kossenkov, A.V., George, D.L., Murphy, M.E., Dotiwala, F.: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Nature Communications 11(1): 473, 2020. Notes: *Co-first author.
122 Leu, J.I., Murphy, M.E., George, D.L.: Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53. Proc. Natl. Acad. Sci. USA. 117(43): 26804-26811, 2020.
218 Barnoud, T., Leung*, J.C., Leu*, J.I., Basu*, S., Poli*, A.N.R., Parris, J.L.D., Indeglia, A., Martynyuk, T., Good, M., Gnanapradeepan, K., Sanseviero, E., Moeller, R., Tang, H.Y., Cassel, J., Kossenkov, A.V., Liu, Q., Speicher, D.W., Gabrilovich, D.I., Salvino, J.M., George, D.L., Murphy, M.E.: A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors. Cancer Research. 80(23): 5270-5281, 2020. Notes: *Equal contribution.
1ac Gnanapradeepan, K., Leu, J.I., Basu, S., Barnoud, T., Good, M., Lee, J.V., Quinn, W.J., Kung, C.P., Ahima, R., Baur, J.A., Wellen, K.E., Liu, Q., Schug, Z.T., George, D.L., Murphy, M.E.: Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser. Elife 9: e55994, 2020.
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