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Bryson W. Katona, MD, PhD
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Jeffery and Cynthia King Associate Professor of Lynch Syndrome Research
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Director, Gastrointestinal Cancer Genetics Program, Penn Medicine
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Director, Gastrointestinal Cancer Risk Evaluation Program, Penn Medicine
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Member, Abramson Cancer Center - Cancer Control Program
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Member, Institute for Translational Medicine and Therapeutics - University of Pennsylvania
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Member, Center for Molecular Studies in Digestive and Liver Diseases - University of Pennsylvania
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Executive Director, King Center for Lynch Syndrome
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Department: Medicine
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Graduate Group Affiliations
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Contact information
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Perelman Center for Advanced Medicine
23 3400 Civic Center Boulevard
35 751 South Pavilion
Philadelphia, PA 19104
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23 3400 Civic Center Boulevard
35 751 South Pavilion
Philadelphia, PA 19104
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Office: 215-349-8222
32 Fax: 215-349-5915
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32 Fax: 215-349-5915
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Publications
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Education:
21 7 BA 16 (Chemistry) c
33 University of Pennsylvania, 2002.
21 7 MS 16 (Chemistry) c
33 University of Pennsylvania, 2002.
21 8 PhD 19 (Biochemistry) c
4e Washington University in St. Louis School of Medicine, 2009.
21 7 MD c
4e Washington University in St. Louis School of Medicine, 2009.
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Permanent link21 7 BA 16 (Chemistry) c
33 University of Pennsylvania, 2002.
21 7 MS 16 (Chemistry) c
33 University of Pennsylvania, 2002.
21 8 PhD 19 (Biochemistry) c
4e Washington University in St. Louis School of Medicine, 2009.
21 7 MD c
4e Washington University in St. Louis School of Medicine, 2009.
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Description of Clinical Expertise
75 Hereditary gastrointestinal cancer and polyposis syndromes. Gastrointestinal cancer risk evaluation.71
Description of Research Expertise
92 Hereditary gastrointestinal cancer and polyposis syndromes, especially hereditary colorectal cancer and hereditary gastric cancer.e 29
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145 Bracht SA, Rong J, Gier RA, DeMarshall M, Golden H, Dhakal D, McDevitt JC, Mo F, Furth EE, Starling AS, Muir AB, Falk GW, Katona BW, Stanger BZ, Zhang NR, Shaffer SM.: Mitochondrial clone tracing within spatially intact human tissues. bioRxiv Jul 2025.
1a4 Shaukat A, Burke CA, Chan AT, Grady WM, Gupta S, Katona BW, Ladabaum U, Liang PS, Liu JJ, Putcha G, Robertson DJ, Schoen RE, Meng Z, Piscitello A, Sun CK, Xu C, Lin CJ, Lee LC, Baldo L, Levin TR; PREEMPT CRC Investigators.: Clinical Validation of a Circulating Tumor DNA-Based Blood Test to Screen for Colorectal Cancer. JAMA 334: 56-63, Jul 2025.
100 Dudley B, Katona BW.: Improving uptake of germline genetic testing amongst individuals at high-risk of pancreatic ductal adenocarcinoma. Transl Gastroenterol Hepatol 10: 41, Jul 2025.
164 Palma NA, Lucas AL, Katona BW, Athanasiou A, Kureshi NM, Ford L, Keller T, Weber S, Schiess R, King T, Simeone DM, Brand R.: A High Performing Biomarker Signature for Detecting Early-Stage Pancreatic Ductal Adenocarcinoma in High-Risk Individuals. Cancers (Basel) 17: 1866, Jun 2025.
19a Katona BW, Stanich PP, Chittenden A, Hall MJ, Idos GE, Koptiuch C, Latham A, Pearlman R, Singh A, Levinson E, Dudley B.: Strategic Plan of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC): A practical roadmap to move the hereditary gastrointestinal cancer field forward. Fam Cancer 24: 51, Jun 2025.
fd Haider M, Masood M, Katona BW, Burke CA, Mankaney GN.: Worldwide Impact of Upper Gastrointestinal Disease in Familial Adenomatous Polyposis. Diagnostics (Basel) 15: 1218, May 2025.
19d Latham A, Liu YL, Constantino G, Borio M, McCoy S, Dudzik C, Heiman J, Kemel Y, Ukaegbu C, Carlo MI, Ranganathan M, Kane S, Long JM, Syngal S, Markowitz AJ, Stadler ZK, Yurgelun MB, Katona BW.: Neoplasia Detection Through Colonic Surveillance Among Young Individuals With MSH6 / PMS2 -Associated Lynch Syndrome. Am J Gastroenterol Feb 2025.
de Heller M, Mann DA, Katona BW.: Current Approaches of Pancreatic Cancer Surveillance in High-Risk Individuals. J Gastrointest Cancer 56: 61, Feb 2025.
1cd Katona BW, Lubinski J, Pal T, Huzarski T, Foulkes WD, Moller P, Eisen A, Randall Armel S, Neuhausen SL, Raj R, Aeilts A, Singer CF, Bordeleau L, Karlan B, Olopade O, Tung N, Zakalik D, Kotsopoulos J, Fruscio R, Eng C, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group.: The incidence of pancreatic cancer in women with a BRCA1 or BRCA2 mutation. Cancer 131: e35666, Jan 2025.
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Selected Publications
143 Fernandes CJ, Du YK, Naumer A, Kagami LA, Le A, Good M, Duvall M, Powers J, Zelley K, Maese LD, MacFarland S, Kohlmann W, Maxwell KN, Katona BW.: Pancreatic Cancer Risk and Screening Outcomes in Li-Fraumeni Syndrome. Pancreas 54: e618-e623, Aug 2025.145 Bracht SA, Rong J, Gier RA, DeMarshall M, Golden H, Dhakal D, McDevitt JC, Mo F, Furth EE, Starling AS, Muir AB, Falk GW, Katona BW, Stanger BZ, Zhang NR, Shaffer SM.: Mitochondrial clone tracing within spatially intact human tissues. bioRxiv Jul 2025.
1a4 Shaukat A, Burke CA, Chan AT, Grady WM, Gupta S, Katona BW, Ladabaum U, Liang PS, Liu JJ, Putcha G, Robertson DJ, Schoen RE, Meng Z, Piscitello A, Sun CK, Xu C, Lin CJ, Lee LC, Baldo L, Levin TR; PREEMPT CRC Investigators.: Clinical Validation of a Circulating Tumor DNA-Based Blood Test to Screen for Colorectal Cancer. JAMA 334: 56-63, Jul 2025.
100 Dudley B, Katona BW.: Improving uptake of germline genetic testing amongst individuals at high-risk of pancreatic ductal adenocarcinoma. Transl Gastroenterol Hepatol 10: 41, Jul 2025.
164 Palma NA, Lucas AL, Katona BW, Athanasiou A, Kureshi NM, Ford L, Keller T, Weber S, Schiess R, King T, Simeone DM, Brand R.: A High Performing Biomarker Signature for Detecting Early-Stage Pancreatic Ductal Adenocarcinoma in High-Risk Individuals. Cancers (Basel) 17: 1866, Jun 2025.
19a Katona BW, Stanich PP, Chittenden A, Hall MJ, Idos GE, Koptiuch C, Latham A, Pearlman R, Singh A, Levinson E, Dudley B.: Strategic Plan of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC): A practical roadmap to move the hereditary gastrointestinal cancer field forward. Fam Cancer 24: 51, Jun 2025.
fd Haider M, Masood M, Katona BW, Burke CA, Mankaney GN.: Worldwide Impact of Upper Gastrointestinal Disease in Familial Adenomatous Polyposis. Diagnostics (Basel) 15: 1218, May 2025.
19d Latham A, Liu YL, Constantino G, Borio M, McCoy S, Dudzik C, Heiman J, Kemel Y, Ukaegbu C, Carlo MI, Ranganathan M, Kane S, Long JM, Syngal S, Markowitz AJ, Stadler ZK, Yurgelun MB, Katona BW.: Neoplasia Detection Through Colonic Surveillance Among Young Individuals With MSH6 / PMS2 -Associated Lynch Syndrome. Am J Gastroenterol Feb 2025.
de Heller M, Mann DA, Katona BW.: Current Approaches of Pancreatic Cancer Surveillance in High-Risk Individuals. J Gastrointest Cancer 56: 61, Feb 2025.
1cd Katona BW, Lubinski J, Pal T, Huzarski T, Foulkes WD, Moller P, Eisen A, Randall Armel S, Neuhausen SL, Raj R, Aeilts A, Singer CF, Bordeleau L, Karlan B, Olopade O, Tung N, Zakalik D, Kotsopoulos J, Fruscio R, Eng C, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group.: The incidence of pancreatic cancer in women with a BRCA1 or BRCA2 mutation. Cancer 131: e35666, Jan 2025.
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