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Iain Mathieson, Ph.D.
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Associate Professor of Genetics
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Department: Genetics
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Graduate Group Affiliations
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Contact information
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405A Clinical Research Building
3b 415 Curie Boulevard
Philadelphia, PA 19104-6145
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3b 415 Curie Boulevard
Philadelphia, PA 19104-6145
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Office: 215-573-1835
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Email:
mathi@upenn.edu
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mathi@upenn.edu
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Education:
21 7 BA 18 (Mathematics) c
2d Cambridge University, 2005.
21 a MPhil 20 (Statistical Science) c
2d Cambridge University, 2006.
21 a DPhil 2a (Genomic Medicine & Statistics) c
2a Oxford University, 2013.
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Permanent link21 7 BA 18 (Mathematics) c
2d Cambridge University, 2005.
21 a MPhil 20 (Statistical Science) c
2d Cambridge University, 2006.
21 a DPhil 2a (Genomic Medicine & Statistics) c
2a Oxford University, 2013.
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100 Ramos-Almodóvar F, Gao Z, Voight BF, Mathieson I.: Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes. PNAS 123: e2516368123, Mar 2026.
11b Shi Z, Mandla R, Li J, Li X, Zhang ZE, Chen S, Lapinska S, Flynn-Carroll AO, Pasaniuc B, Epstein DJ, Mathieson I.: Genome-wide analysis implicates inner ear development in Ménière's disease. medRxiv Feb 2026.
ec Costantino M, Fonseca R, Liu Z, Huang Z, Sankararaman S, Mathieson I, Dahl A.: Choice of phenotype scale is critical in biobank-based G×E tests. bioRxiv Jan 2026.
c1 Colbran LL, Terhorst J, Mathieson I.: Global patterns of natural selection inferred using ancient DNA. bioRxiv Jan 2026.
9b Flint J, Mathieson I: What's in the junk? London Review of Books 47(21), Nov 2025.
207 Cox SL, Kaymak-Loveless K, Shin C, Alihodžić T, Alt KW, Atanassova N, Binder D, Čaušević-Bully M, Chohadzhiev A, Chohadzhiev S, Duday H, Gaydarska B, Khudaverdyan A, Micó Perez R, Nicklisch N, Novak M, Oliart Caravatti C, Réveillas H, Rivollat M, Rottier S, Tončinić D, Zäuner S, Mathieson I: Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans. Current Biology 35(22): 5654-5665, Nov 2025.
128 Aw AJ, Mandla R, Shi Z; Penn Medicine Biobank; Pasaniuc B, Mathieson I.: Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations. Genetics 231: iyaf213, Oct 2025.
c0 Mathieson I.: Polygenic prediction of human complex traits using ancient DNA. Curr Opin Genet Dev 95: 102396, Aug 2025.
183 Mies G, Tsao NL, Houy A, Coupland SE, Kalirai H, Försti A, Hemminki K, Thomsen H, Stern MH, Shields CL, Damrauer SM, Ewens KG, Ganguly A, Mathieson I.: Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity. HGG Adv 6: 100465, Jul 2025.
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Selected Publications
c5 Mies G, Mathieson I: Local ancestry inference identifies robust evidence of selection in Neolithic Europe. bioRxiv Apr 2026.100 Ramos-Almodóvar F, Gao Z, Voight BF, Mathieson I.: Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes. PNAS 123: e2516368123, Mar 2026.
11b Shi Z, Mandla R, Li J, Li X, Zhang ZE, Chen S, Lapinska S, Flynn-Carroll AO, Pasaniuc B, Epstein DJ, Mathieson I.: Genome-wide analysis implicates inner ear development in Ménière's disease. medRxiv Feb 2026.
ec Costantino M, Fonseca R, Liu Z, Huang Z, Sankararaman S, Mathieson I, Dahl A.: Choice of phenotype scale is critical in biobank-based G×E tests. bioRxiv Jan 2026.
c1 Colbran LL, Terhorst J, Mathieson I.: Global patterns of natural selection inferred using ancient DNA. bioRxiv Jan 2026.
9b Flint J, Mathieson I: What's in the junk? London Review of Books 47(21), Nov 2025.
207 Cox SL, Kaymak-Loveless K, Shin C, Alihodžić T, Alt KW, Atanassova N, Binder D, Čaušević-Bully M, Chohadzhiev A, Chohadzhiev S, Duday H, Gaydarska B, Khudaverdyan A, Micó Perez R, Nicklisch N, Novak M, Oliart Caravatti C, Réveillas H, Rivollat M, Rottier S, Tončinić D, Zäuner S, Mathieson I: Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans. Current Biology 35(22): 5654-5665, Nov 2025.
128 Aw AJ, Mandla R, Shi Z; Penn Medicine Biobank; Pasaniuc B, Mathieson I.: Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations. Genetics 231: iyaf213, Oct 2025.
c0 Mathieson I.: Polygenic prediction of human complex traits using ancient DNA. Curr Opin Genet Dev 95: 102396, Aug 2025.
183 Mies G, Tsao NL, Houy A, Coupland SE, Kalirai H, Försti A, Hemminki K, Thomsen H, Stern MH, Shields CL, Damrauer SM, Ewens KG, Ganguly A, Mathieson I.: Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity. HGG Adv 6: 100465, Jul 2025.
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