David R Roalf
Department of Psychiatry
10 Gates Building
University of Pennsylvania
Philadelphia, PA 19104-4283
Fax: (215) 662-7903
B.S. (Biological Psychology)
The College of William and Mary, 2001.
Ph.D. (Behavioral Neuroscience)
Oregon Health & Science University, 2010.
Virginia State Governor's Fellow, Governor's Office of Virginia, 2001-2001.
NIH T32 Neuroscience of Aging Predoctoral Fellowship, Oregon Health & Science University, 2006-2008.
N.L. Tartar Research Fellow, Oregon Health & Science University, 2007-2007.
Functional Magnetic Resonance Fellow, University of Michigan, 2007-2007.
Multimodal Neuroimaging Fellow, University of Pittsburgh & Carnegie Mellon University, 2008-2008.
Decision Science Fellow, University of Michigan, 2009-2009.
NIH T32 Neuropsychiatry Postdoctoral Fellowship, University of Pennsylvania, 2010-2013.
Description of Research ExpertiseResearch Interests: My research interests include the neural basis of neuropsychiatric disorders and cognitive aging, including changes in social-emotional processing, memory and decision-making.
Keywords: MRI, neuropsychiatry, cognitive aging, Diffusion MRI,
Research Details: My research is motivated by the need to better understand the pathophysiology of brain dysfunction. SOver the last two decades I have built an arsenal of skills in cognitive and behavioral neuroscientific methods, including psychophysical testing, EEG, structural and functional MRI, diffusion tensor imaging and magnetic resonance spectroscopy, that are useful for evaluating brain-behavior associations. The primary purpose of my research is to strengthen empirical knowledge about brain and behavior associations to better understand cognitive disturbances, particularly in neuropsychiatric and aging populations. My long-term goal is to use advanced multimodal cognitive neuroscientific approaches to facilitate early identification of individuals at-risk for neuropsychiatric or neurodegenerative disease.
Selected PublicationsRoalf David, Moore Tyler, Wolk David, Arnold Steven, Mechanic-Hamilton Dawn, Rick Jacqueline, Kabadi Sushila, Ruparel Kosha, Chen-Plotkin Alice, Chahine Lama, Dahodwala Nabila, Duda John, Weintraub Daniel, Moberg Paul: Defining and validating a short form Montreal Cognitive Assessment (s-MoCA) for use in neurodegenerative disease. Journal of neurology, neurosurgery, and psychiatry 87(12): 1303-1310, Apr 2016.
Satterthwaite Theodore, Wolf Daniel, Calkins Monica, Vandekar Simon, Erus Guray, Ruparel Kosha, Roalf David, Linn Kristin, Elliott Mark, Moore Tyler, Hakonarson Hakon, Shinohara Russell, Davatzikos Christos, Gur Ruben, Gur Raquel: Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms. JAMA psychiatry 73(5): 515-24, May 2016.
Roalf David, Quarmley Megan, Elliott Mark, Satterthwaite Theodore, Vandekar Simon, Ruparel Kosha, Gennatas Efstathios, Calkins Monica, Moore Tyler, Hopson Ryan, Prabhakaran Karthik, Jackson Chad, Verma Ragini, Hakonarson Hakon, Gur Ruben, Gur Raquel: The impact of quality assurance assessment on diffusion tensor imaging outcomes in a large-scale population-based cohort. NeuroImage 125: 903-19, Jan 2016.
Vandekar Simon, Shinohara Russell, Raznahan Armin, Hopson Ryan, Roalf David, Ruparel Kosha, Gur Ruben, Gur Raquel, Satterthwaite Theodore: Subject-level measurement of local cortical coupling. NeuroImage 133: 88-97, Jun 2016.
Kos Mark, Carless Melanie A, Peralta Juan, Blackburn August, Almeida Marcio, Roalf David, Pogue-Geile Michael, Prasad Konasale, Gur Ruben, Nimgaonkar Vishwajit, Curran Joanne, Duggirala Ravi, Glahn David, Blangero John, Gur Raquel, Almasy Laura: Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk. Schizophrenia bulletin 42(2): 288-300, Mar 2016.
Moore Tyler, Reise Steven, Roalf David, Satterthwaite Theodore, Davatzikos Christos, Bilker Warren, Port Allison, Jackson Chad, Ruparel Kosha, Savitt Adam, Baron Robert, Gur Raquel, Gur Ruben: Development of an Itemwise Efficiency Scoring Method: Concurrent, Convergent, Discriminant, and Neuroimaging-Based Predictive Validity Assessed in a Large Community Sample. Psychological assessment 28(12): 1529-1542, Dec 2016.
Shanmugan Sheila, Wolf Daniel, Calkins Monica E, Moore Tyler, Ruparel Kosha, Hopson Ryan D, Vandekar Simon N, Roalf David, Elliott Mark, Jackson Chad, Gennatas Efstathios, Leibenluft Ellen, Pine Daniel, Shinohara Russell, Hakonarson Hakon, Gur Ruben, Gur Raquel, Satterthwaite Theodore: Common and Dissociable Mechanisms of Executive System Dysfunction Across Psychiatric Disorders in Youth. The American journal of psychiatry 173(5): 517-26, May 2016.
Satterthwaite Theodore, Connolly John, Ruparel Kosha, Calkins Monica, Jackson Chad, Elliott Mark, Roalf David, Ryan Hopsona, Karthik Prabhakaran, Behr Meckenzie, Qiu Haijun, Mentch Frank, Chiavacci Rosetta, Sleiman Patrick, Gur Ruben, Hakonarson Hakon, Gur Raquel: The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth. NeuroImage 124(Pt B): 1115-9, Jan 2016.
Perlis Michael, Roalf David, Kloss Jaqueline: A commentary on the "Functioning of three attentional networks and vigilance in primary insomnia". Sleep medicine 16(12): 1567-8, Dec 2015.
Calkins Monica, Merikangas Kathleen, Moore Tyler, Burstein Marcy, Behr Meckenzie, Satterthwaite Theodore, Ruparel Kosha, Wolf Daniel, Roalf David, Mentch Frank, Qiu Haijun, Chiavacci Rosetta, Connolly John, Sleiman Patrick, Gur Ruben, Hakonarson Hakon, Gur Raquel: The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative. Journal of child psychology and psychiatry, and allied disciplines 56(12): 1356-69, Dec 2015.
Vandekar Simon, Shinohara Russell, Raznahan Armin, Roalf David, Ross Michelle, DeLeo Nicholas, Ruparel Kosha, Verma Ragini, Wolf Daniel, Gur Ruben, Gur Raquel, Satterthwaite Theodore: Topologically dissociable patterns of development of the human cerebral cortex. The Journal of neuroscience: the official journal of the Society for Neuroscience 35(2): 599-609, Jan 2015.
Schmitt Eric, Vandekar Simon, Yi James, Calkins Monica, Ruparel Kosha, Roalf David, Whinna Daneen, Souders Margaret, Satterthwaite Theodore, Prabhakaran Karthik, McDonald-McGinn Donna, Zackai Elaine, Gur Ruben, Emanuel Beverly, Gur Raquel: Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome. Biological psychiatry 78(2): 135-43, Jul 2015.
Roalf David, Gur Raquel, Verma Ragini, Parker William, Quarmley Megan, Ruparel Kosha, Gur Ruben: White matter microstructure in schizophrenia: associations to neurocognition and clinical symptomatology. Schizophrenia research 161(1): 42-9, Jan 2015.
van Steenoven Inger, Aarsland Dag, Hurtig Howard, Chen-Plotkin Alice, Duda John, Rick Jacqueline, Chahine Lama, Dahodwala Nabila, Trojanowski John, Roalf David, Moberg Paul, Weintraub Daniel: Conversion between mini-mental state examination, montreal cognitive assessment, and dementia rating scale-2 scores in Parkinson's Disease. Movement disorders: official journal of the Movement Disorder Society 29(14): 1809-15, Dec 2014.
Roalf David, Vandekar Simon, Almasy Laura, Ruparel Kosha, Satterthwaite Theodore, Elliott Mark, Podell Jamie, Gallagher Sean, Jackson Chad, Prasad Konasale, Wood Joel, Pogue-Geile Michael, Nimgaonkar Vishwajit, Gur Ruben, Gur Raquel: Heritability of subcortical and limbic brain volume and shape in multiplex-multigenerational families with schizophrenia. Biological psychiatry 77(2): 137-46, Jan 2015.
Satterthwaite Theodore, Shinohara Russell, Wolf Daniel, Hopson Ryan, Elliott Mark, Vandekar Simon, Ruparel Kosha, Calkins Monica, Roalf David, Gennatas Efstathios, Jackson Chad, Erus Guray, Prabhakaran Karthik, Davatzikos Christos, Detre John, Hakonarson Hakon, Gur Ruben, Gur Raquel: Impact of puberty on the evolution of cerebral perfusion during adolescence. Proceedings of the National Academy of Sciences of the United States of America 111(23): 8643-8, Jun 2014.
Roalf David, Gur Raquel, Ruparel Kosha, Calkins Monica, Satterthwaite Theodore, Bilker Warren, Hakonarson Hakon, Harris Lauren Julius, Gur Ruben: Within-individual variability in neurocognitive performance: age- and sex-related differences in children and youths from ages 8 to 21. Neuropsychology 28(4): 506-18, Jul 2014.
Satterthwaite Theodore, Wolf Daniel, Roalf David, Ruparel Kosha, Erus Guray, Vandekar Simon, Gennatas Efstathios, Elliott Mark, Smith Alex, Hakonarson Hakon, Verma Ragini, Davatzikos Christos, Gur Raquel, Gur Ruben: Linked Sex Differences in Cognition and Functional Connectivity in Youth. Cerebral cortex (New York, N.Y.: 1991) 25(9): 2383-94, Sep 2015.
Satterthwaite Theodore, Vandekar Simon, Wolf Daniel, Ruparel Kosha, Roalf David, Jackson Chad, Elliott Mark, Bilker Warren, Calkins Monica, Prabhakaran Karthik, Davatzikos Christos, Hakonarson Hakon, Gur Raquel, Gur Ruben: Sex differences in the effect of puberty on hippocampal morphology. Journal of the American Academy of Child and Adolescent Psychiatry 53(3): 341-50.e1, Mar 2014.
Roalf David, Ruparel Kosha, Gur Raquel, Bilker Warren, Gerraty Raphael, Elliott Mark, Gallagher Sean, Almasy Laura, Pogue-Geile Michael, Prasad Konasale, Wood Joel, Nimgaonkar Vishwajit, Gur Ruben: Neuroimaging predictors of cognitive performance across a standardized neurocognitive battery. Neuropsychology 28(2): 161-76, Mar 2014.
Satterthwaite Theodore, Wolf Daniel, Erus Guray, Ruparel Kosha, Elliott Mark, Gennatas Efstathios, Hopson Ryan, Jackson Chad, Prabhakaran Karthik, Bilker Warren, Calkins Monica, Loughead James, Smith Alex, Roalf David, Hakonarson Hakon, Verma Ragini, Davatzikos Christos, Gur Ruben, Gur Raquel: Functional maturation of the executive system during adolescence. The Journal of neuroscience: the official journal of the Society for Neuroscience 33(41): 16249-61, Oct 2013.
Cai Kejia, Singh Anup, Roalf David, Nanga Ravi Prakash Reddy, Haris Mohammad, Hariharan Hari, Gur Ruben, Reddy Ravinder: Mapping glutamate in subcortical brain structures using high-resolution GluCEST MRI. NMR in biomedicine 26(10): 1278-84, Oct 2013.
Roalf David, Moberg Paul, Xie Sharon, Wolk David, Moelter Stephen, Arnold Steven: Comparative accuracies of two common screening instruments for classification of Alzheimer's disease, mild cognitive impairment, and healthy aging. Alzheimer's & dementia: the journal of the Alzheimer's Association 9(5): 529-37, Sep 2013.
Roalf David, Ruparel Kosha, Verma Ragini, Elliott Mark, Gur Raquel, Gur Ruben: White matter organization and neurocognitive performance variability in schizophrenia. Schizophrenia research 143(1): 172-8, Jan 2013.
Roalf David, Gur Ruben, Almasy Laura, Richard Jan, Gallagher Sean, Prasad Konasale, Wood Joel, Pogue-Geile Michael, Nimgaonkar Vishwajit, Gur Raquel: Neurocognitive performance stability in a multiplex multigenerational study of schizophrenia. Schizophrenia bulletin 39(5): 1008-17, Sep 2013.
Roalf David, Pruis Trisha, Stevens Alexander, Janowsky Jeri: More is less: emotion induced prefrontal cortex activity habituates in aging. Neurobiology of aging 32(9): 1634-50, Sep 2011.
Roalf David, Mitchell Suzanne, Harbaugh William, Janowsky Jeri: Risk, reward, and economic decision making in aging. The journals of gerontology: Series B, Psychological sciences and social sciences 67(3): 289-98, May 2012.
Moberg Paul, Balderston Catherine, Rick Jacqueline, Roalf David, Weintraub Daniel, Kleiner-Fisman Galit, Stern Matthew, Duda John: Phenylthiocarbamide (PTC) perception in Parkinson disease. Cognitive and behavioral neurology: official journal of the Society for Behavioral and Cognitive Neurology 20(3): 145-8, Sep 2007.
Moberg Paul, McGue Colleen, Kanes Stephen, Roalf David, Balderston Catherine, Gur Raquel, Kohler Christian, Turetsky Bruce: Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance. Schizophrenia research 90(1-3): 221-8, Feb 2007.
Roalf David, Turetsky Bruce, Owzar Kiana, Balderston Catherine, Johnson Sarah, Brensinger Colleen, Gur Raquel, Siegel Steven, Moberg Paul: Unirhinal olfactory function in schizophrenia patients and first-degree relatives. The Journal of neuropsychiatry and clinical neurosciences 18(3): 389-96, 2006.
Moberg Paul, Arnold Steven, Doty Richard, Gur Raquel, Balderston Catherine, Roalf David, Gur Ruben, Kohler Christian, Kanes Stephen, Siegel Steven, Turetsky Bruce: Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures. Journal of clinical and experimental neuropsychology 28(8): 1444-61, Nov 2006.
Robinson Keith, Dennison Andrew, Roalf David, Noorigian Joseph, Cianci Heather, Bunting-Perry Lisette, Moberg Paul, Kleiner-Fisman Galit, Martine Rebecca, Duda John, Jaggi Jurg, Stern Matthew: Falling risk factors in Parkinson's disease. NeuroRehabilitation 20(3): 169-82, 2005.
Moberg Paul, Arnold Steven, Roalf David, Balderston Catherine, Abbazia Jaime, Kohler Christian, Gur Raquel, Turetsky Bruce: Apolipoprotein E genotype and odor identification in schizophrenia. The Journal of neuropsychiatry and clinical neurosciences 18(2): 231-3, 2006.
Roalf David, Lowery Natasha, Turetsky Bruce: Behavioral and physiological findings of gender differences in global-local visual processing. Brain and cognition 60(1): 32-42, Feb 2006.
Moberg Paul, Roalf David, Balderston Catherine, Kanes Stephen, Gur Raquel, Turetsky Bruce: Phenylthiocarbamide perception in patients with schizophrenia and first-degree family members. The American journal of psychiatry 162(4): 788-90, Apr 2005.
Moberg Paul, Roalf David, Gur Raquel, Turetsky Bruce: Smaller nasal volumes as stigmata of aberrant neurodevelopment in schizophrenia. The American journal of psychiatry 161(12): 2314-6, Dec 2004.
Turetsky Bruce, Moberg Paul, Roalf David, Arnold Steve, Gur Raquel: Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia. Archives of general psychiatry 60(12): 1193-200, Dec 2003.