Department of Psychiatry

faculty photo

Mario Cristancho

Associate Professor of Clinical Psychiatry
Clinician, Neuromodulation Service (TMS, Vagus Nerve Stimulation, ECT, and Deep Brain Stimulation), Dept. of Psychiatry, University of Penn., Philadelphia,PA
Attending Physician, Pennsylvania Hospital, Department of Psychiatry, Philadelphia,PA
Attending Physician, Hospital of the University of Pennsylvania, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia,PA
Clinician, Comprehensive Consultation Service Mood Disorders Treatment Center, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia,PA
Medical Director, Electroconvulsive Therapy service., Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia,PA
Medical Director, Transcranial magnetic stimulation and neuromodulation program, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia,PA
Chief of Interventional Psychiatry, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia,PA
Department: Psychiatry
Contact information
3535 Market Street
Mezzanine
Philadelphia, PA 19104
Office: 215-746-7181
Fax: 215-746-4116
Email: marioc@pennmedicine.upenn.edu
Links
PENN INTERVENTIONAL PSYCHIATRY NETWORK
Education
M.D.
Universidad Industrial de Santander (UIS), Colombia , 2005.
Post-Graduate Training
Intern in Psychiatry, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia,PA, 2008-2009.
 Resident in Psychiatry, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia,PA, 2009-2012.
 Postdoctoral Fellow, Mood and Anxiety Disorders Treatment and Research Program, Department of Psychiatry, University of Pennsylvania, Philadelphia,PA, 2012-2013.
Permanent link
 
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Selected Publications

Seilheimer RL, Qiu L, Rocchio G, Nho YH, Campos G, Horn A, Rolle CE, Buch VP, Ganguly TM, Cristancho M, Oathes DJ, Brown L, Pesaran B, Krystal AD, Chang EF, Lee MA, Miller KJ, Barbosa DAN, Williams NR, Halpern CH, Scangos KW: Stereo-encephalography-guided multi-lead deep brain stimulation for treatment-refractory obsessive-compulsive disorder - Study design and individualized surgical targeting approach. Journal of Affective Disorders 402(121349), Jun 2026 Notes: https://doi.org/10.1016/j.jad.2026.121349.

 Nho YH, Qiu L, Seilheimer RL, Campos G, Chang A, Wang Z, Magnotti JF, Beauchamp MS, Barbosa DAN, Horn A, Williams NR, Brown LA, Ganguly TM, Cristancho M, Pesaran B, Oathes DJ, Miller KJ, Scangos KW, Halpern CH: Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics. Cell 189(3): 739-747, Feb 2026 Notes: https://doi.org/10.1016/j.cell.2025.12.037.

 Rosenthal ZP, Majeski JB, Somarowthu A, Quinn DK, Lindquist BE, Putt ME, Karaj A, Favilla CG, Baker WB, Hosseini G, Rodriguez JP, Cristancho MA, Sheline YI, William Shuttleworth C, Abbott CC, Yodh AG, Goldberg EM: Electroconvulsive therapy generates a post-ictal wave of spreading depolarization in mice and humans Nature Communications 16(1): 4619, May 2025 Notes: https://doi.org/10.1038/s41467-025-59900-1.

 Choi W, Nho YH, Qiu L, Chang A, Campos G, Seilheimer RL, Wilent WB, Bakalov D, Firdous N, Kerr M, Joshi D, Maze G, Topalovic U, Batista D, Suthana N, Amaro A, Hayes MR, Cajigas I, Cristancho M, Allison KC, Pesaran B, Scangos KW, Gold JI, Wadden TA, Halpern CH. : Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide. Nature Medicine 31(12): 4038-4043, Dec 2025 Notes: https://doi.org/10.1038/s41591-025-04035-5.

 Tyler J., Connolly Gibbons M.B., Crits-Christoph P., Cristancho M., Galbraith J., Chiu R.Y., Duong L.A., & Oquendo M.A.: A multifaceted outpatient treatment model for mood and anxiety disorders designed to optimize both treatment outcomes and access to care. Annual Convention of the Association for Behavioral and Cognitive Therapies. New Orleans, LA Nov 2025 Notes: Presentation.

 Connolly Gibbons MB, Tyler J, Crits-Christoph P, Cristancho M, Galbraith J, Chiu RY, Duong LA, Oquendo MA: A multifaceted outpatient treatment model for mood and anxiety disorders designed to optimize both treatment outcomes and access to care. Psychotherapy 62(3): 337-347, Sep 2025 Notes: https://doi.org/10.1037/pst0000576.

 Zheng J, Sheline Y, Cristancho M,: Vagus Nerve Stimulation for Treatment-Resistant Depression. Dwight l. Evans, MD Penn Psychiatry Research Day, Philadelphia, PA Apr 2025 Notes: Poster presentation.

 Connolly-Gibbons MB, Tyler J, Crits-Christoph P, Cristancho MA, Galbraith J, Chiu R, Duong LA, Oquendo, MA, Calloway A: A Multifaceted Outpatient Treatment Model Designed to Optimize Treatment Outcomes and Access to Care Dwight l. Evans, MD Penn Psychiatry Research Day, Philadelphia, PA Apr 2025 Notes: Poster presentation.

 Trapp NT, Purgiant A, Taylor JJ, Singh MK, Oberman LM, Mickey BJ, Youssef NA, Solzbacher D, Zebley B, Cabrera LY, Conroy S, Cristancho MA, Richards JR, Flood MJ, Barbour T, Blumberger DM, Taylor SF, Feifel DF, Reti IM, McClintock SM, Lisanby SH, Husain MM: Consensus Review and Considerations on TMS to Treat Depression. International Brain Stimulation Conference, Kobe Japan Feb 2025 Notes: Poster presentation.

 Trapp NT, Purgianto A, Taylor JJ, Singh MK, Oberman LM, Mickey BJ, Youssef NA, Solzbacher D, Zebley B, Cabrera LY, Conroy S, Cristancho M, Richards JR, Flood MJ, Barbour T, Blumberger DM, Taylor SF, Feifel D, Reti IM, McClintock SM, Lisanby SH, Husain MM: Consensus review and considerations on TMS to treat depression: A comprehensive update endorsed by the National Network of Depression Centers, the Clinical TMS Society, and the International Federation of Clinical Neurophysiology. Clinical Neurophysiology 170: 206-233, Feb 2025 Notes: https://doi.org/10.1016/j.clinph.2024.12.015.
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Last updated: 07/27/2026
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