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Melissa S Xanthopoulos
4fAssociate Professor of Clinical Psychiatry
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Co-Leader of Continuous Positive Airway Pressure Quality Improvement Initiative, Children's Hospital of Philadelphia
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Director, Continuous Positive Airway Pressure Adherence Program, Children's Hospital of Philadelphia
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Department: Psychiatry
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Contact information
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Children’s Hospital of Philadelphia
38 The Hub for Clinical Collaboration, Office 14542
3e 3500 Civic Center Boulevard
Philadelphia, PA 19104
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38 The Hub for Clinical Collaboration, Office 14542
3e 3500 Civic Center Boulevard
Philadelphia, PA 19104
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Links
a5 Patient story referencing care provided by Dr. Xanthopoulos
70 CHOP News
10f Video abstract: Physical Activity in Youth with Down Syndrome and its Relationship with Adiposity for Journal of Developmental and Behavioral Pediatrics.
dd 6 Ways for Schools to Promote Student-Athletes’ Well-Being for Education Week
9c Interview from APSS 2023 on infants and CPAP
87 About CHOP Sleep Center
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a5 Patient story referencing care provided by Dr. Xanthopoulos
70 CHOP News
10f Video abstract: Physical Activity in Youth with Down Syndrome and its Relationship with Adiposity for Journal of Developmental and Behavioral Pediatrics.
dd 6 Ways for Schools to Promote Student-Athletes’ Well-Being for Education Week
9c Interview from APSS 2023 on infants and CPAP
87 About CHOP Sleep Center
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Education:
21 7 BS 2d (Kinesiology, Minor in Psychology) c
37 Pennsylvania State University , 1998.
21 7 MS 29 (Clinical Exercise Physiology) c
34 East Stroudsburg University, 1999.
21 7 MS 32 (Clinical Psychology-Health Psychology) c
2b Drexel University , 2003.
21 8 PhD 20 (Clinical Psychology) c
2b Drexel University , 2006.
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21 7 BS 2d (Kinesiology, Minor in Psychology) c
37 Pennsylvania State University , 1998.
21 7 MS 29 (Clinical Exercise Physiology) c
34 East Stroudsburg University, 1999.
21 7 MS 32 (Clinical Psychology-Health Psychology) c
2b Drexel University , 2003.
21 8 PhD 20 (Clinical Psychology) c
2b Drexel University , 2006.
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Post-Graduate Training
24 b4 Clinical Intern, Clinical Psychology Training Consortium, Alpert Medical School of Brown University Child/Pediatric Psychology Specialization , 2005-2006.
24 8d Postdoctoral Fellow, Center for Obesity Research and Education and Department of Kinesiology, Temple University, 2006-2007.
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Permanent link24 b4 Clinical Intern, Clinical Psychology Training Consortium, Alpert Medical School of Brown University Child/Pediatric Psychology Specialization , 2005-2006.
24 8d Postdoctoral Fellow, Center for Obesity Research and Education and Department of Kinesiology, Temple University, 2006-2007.
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29 pediatric obstructive sleep apnea
20 positive airway pressure
36 pediatric obesity assessment and interventions
1f lifestyle interventions
1d health behavior change
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1f lifestyle interventions
1e health behavior change
29 pediatric obstructive sleep apnea
20 positive airway pressure
19 pediatric obesity
26 neurodevelopmental differences
19 physical activity
27 sport and performance psychology
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Description of Clinical Expertise
1a adherence29 pediatric obstructive sleep apnea
20 positive airway pressure
36 pediatric obesity assessment and interventions
1f lifestyle interventions
1d health behavior change
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Description of Other Expertise
23 quality improvement65
Description of Research Expertise
1a adherence1f lifestyle interventions
1e health behavior change
29 pediatric obstructive sleep apnea
20 positive airway pressure
19 pediatric obesity
26 neurodevelopmental differences
19 physical activity
27 sport and performance psychology
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17f Page SD, Zúñiga, E; Cielo C, Sawyer AM, Xanthopoulos M. : Abstracts for the 2025 ENRS Annual Scientific Sessions: Sleep and Daytime Behavior in Dyads of Adolescents with Down Syndrome and Their Parent: A Feasibility Study. Nursing Research 74(6): E18-E167, Nov 2025 Notes: DOI: 10.1097/NNR.0000000000000859.
170 Stefanovski D, Somayaji M, Ward M, Falvo J, Cornaglia, Tapia IE, Roman, Xanthopoulos M, and Cielo CM.: Accuracy and acceptability of home sleep apnea testing with electroencephalography compared to in-lab polysomnography for the diagnosis of obstructive sleep apnea in children. Journal of Clinical Sleep Medicine 2 5c (eds.). 21(8): 1341-1348, August 2025 Notes: doi: 10.5664/jcsm.11654.
bf CHOP: Finally Breathing Easy: Ava’s Story. https://www.chop.edu/stories/finally-breathing-easy-avas-story June 2025.
12f Xanthopoulos MS, Byars KC, Gurbani N, Meinzen-Derr J, Heubi C, Esbensen A, Yu Y, Tapia IE.: Adherence to a positive airway pressure trial in youth with Down syndrome: A baseline description. Sleep 48(Supplement_1): A432, May 2025.
112 Davidson S, Milaniak I, Arshad SH, Xanthopoulos M.: Day at the Museum: An Experiential Bias Intervention. Medical Education 58(11): 1382-1383, Nov 2024 Notes: doi: 10.1111/medu.15510. Epub 2024 Aug 30.
14c Avitabile CM, O’Brien C, Dureja D, Albizem D, Mota J, Xanthopoulos M, Zemel BS, Cronholm PF: Barriers to and facilitators of physical activity in pediatric pulmonary hypertension. Pulmonary Circulation 14(4): e70000, Oct 2024 Notes: doi: 10.1002/pul2.70000.
d0 Linares I, Borginho C, Sardano1 B, Xavier1 J, Luvizotto AC, Bueno C, Xanthopoulos M, Soster L: Descriptive results of a pilot protocol for PAP adherence in a 66 Brazilian pediatric service. Journal of Sleep Research 33(S1): 143, Sept 2024.
11b Isaiah Hayes: 6 Ways for Schools to Promote Student-Athletes’ Well-Being. Education Week August 2024 Notes: https://www.edweek.org/leadership/6-ways-for-schools-to-promote-student-athletes-well-being/2024/08.
1cc Avitabile K, Mota JP, Yeaman KM, Andrieux SJ, Lechtenberg L, Escobar E, Chuo J, Xanthopoulos MS, Faig W, O’Malley S, Ford E, McBride MG, Paridon SM, Mitchell JA, Zemel B.: Creating a digital approach for promoting physical activity in pediatric pulmonary hypertension: A framework for future interventions. Pulmonary Circulation 14(3): e12402, July 2024 Notes: doi: 10.1002/pul2.12402.
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Selected Publications
1d6 Xanthopoulos MS, Byars K, Meinzen-Derr J, Ebensen A, Xio R, Heubi C, Gurbani NS, Ishman SL, Bradford R, Suzanna Hicks S, Redline S, Tapia IE. : Standard medical care versus enhanced interdisciplinary care for implementation of positive airway pressure in youth with Down syndrome: a randomised controlled trial protocol. BMJ Open 15(11): e110990, Nov 2025 Notes: doi: 10.1136/bmjopen-2025-110990.17f Page SD, Zúñiga, E; Cielo C, Sawyer AM, Xanthopoulos M. : Abstracts for the 2025 ENRS Annual Scientific Sessions: Sleep and Daytime Behavior in Dyads of Adolescents with Down Syndrome and Their Parent: A Feasibility Study. Nursing Research 74(6): E18-E167, Nov 2025 Notes: DOI: 10.1097/NNR.0000000000000859.
170 Stefanovski D, Somayaji M, Ward M, Falvo J, Cornaglia, Tapia IE, Roman, Xanthopoulos M, and Cielo CM.: Accuracy and acceptability of home sleep apnea testing with electroencephalography compared to in-lab polysomnography for the diagnosis of obstructive sleep apnea in children. Journal of Clinical Sleep Medicine 2 5c (eds.). 21(8): 1341-1348, August 2025 Notes: doi: 10.5664/jcsm.11654.
bf CHOP: Finally Breathing Easy: Ava’s Story. https://www.chop.edu/stories/finally-breathing-easy-avas-story June 2025.
12f Xanthopoulos MS, Byars KC, Gurbani N, Meinzen-Derr J, Heubi C, Esbensen A, Yu Y, Tapia IE.: Adherence to a positive airway pressure trial in youth with Down syndrome: A baseline description. Sleep 48(Supplement_1): A432, May 2025.
112 Davidson S, Milaniak I, Arshad SH, Xanthopoulos M.: Day at the Museum: An Experiential Bias Intervention. Medical Education 58(11): 1382-1383, Nov 2024 Notes: doi: 10.1111/medu.15510. Epub 2024 Aug 30.
14c Avitabile CM, O’Brien C, Dureja D, Albizem D, Mota J, Xanthopoulos M, Zemel BS, Cronholm PF: Barriers to and facilitators of physical activity in pediatric pulmonary hypertension. Pulmonary Circulation 14(4): e70000, Oct 2024 Notes: doi: 10.1002/pul2.70000.
d0 Linares I, Borginho C, Sardano1 B, Xavier1 J, Luvizotto AC, Bueno C, Xanthopoulos M, Soster L: Descriptive results of a pilot protocol for PAP adherence in a 66 Brazilian pediatric service. Journal of Sleep Research 33(S1): 143, Sept 2024.
11b Isaiah Hayes: 6 Ways for Schools to Promote Student-Athletes’ Well-Being. Education Week August 2024 Notes: https://www.edweek.org/leadership/6-ways-for-schools-to-promote-student-athletes-well-being/2024/08.
1cc Avitabile K, Mota JP, Yeaman KM, Andrieux SJ, Lechtenberg L, Escobar E, Chuo J, Xanthopoulos MS, Faig W, O’Malley S, Ford E, McBride MG, Paridon SM, Mitchell JA, Zemel B.: Creating a digital approach for promoting physical activity in pediatric pulmonary hypertension: A framework for future interventions. Pulmonary Circulation 14(3): e12402, July 2024 Notes: doi: 10.1002/pul2.12402.
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