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Mitchel Allan Kling

Emeritus Associate Professor CE of Psychiatry
Member, Institute for Translational Medicine and Therapeutics (ITMAT), Perelman School of Medicine at the University of Pennsylvania
Member, Penn Insitute for Immunology (IFI), Perelman School of Medicine, University of Pennsylvania
Director, Psychiatric Emergency Services, Philadelphia VA Medical Center (116) 3900 Woodland Avenue Philadelphia, PA 19104
Member, Institute of Diabetes, Obesity, and Metabolism (IDOM), Perelman School of Medicine, University of Pennsylvania
Fellow, Institute on Aging, Perelman School of Medicine, University of Pennsylvania
Department: Psychiatry

Contact information
VA Medical Center (116)
3900 Woodland Avenue
Philadelphia, PA 19104
Office: 215-823-5800 x3857
Fax: 215-823-4241
Lab: 610-850-2392
BS (Life Sciences (Applied Biology))
Massachusetts Institute of Technology, 1976.
N/A (Medicine (preclinical years))
Rutgers Medical School, 1978.
MD (Medicine, with Honors thesis)
Harvard Medical School, 1981.
Post-Graduate Training
Resident in Psychiatry, University of Pennsylvania Affiliated Hospitals Philadelphia, PA, 1981-1984.
Medical Staff Fellow, National Institute of Mental Health Intramural Research Program Bethesda, MD, 1984-1986.
Senior Staff Fellow, National Institute of Mental Health Intramural Research Program Bethesda, MD, 1986-1990.
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Description of Clinical Expertise

General adult psychiatry and psychopharmacology
Evaluation and management of treatment-resistant mood and anxiety disorders
Emergency psychiatry
Vagus nerve stimulation for treatment-resistant mood disorders

Description of Research Expertise

Endocrine and metabolic aspects of mood and anxiety disorders
Stress neurobiology
Biomarkers of stress, allostatic load, innate immune function, and metabolic syndrome
Clinical trials of psychopharmacologic agents in psychiatric disorders
Clinical trials of vagus nerve stimulation in psychiatric disorders
Endocrine challenge tests
Analysis of pulsatile hormone secretion
Circadian rhythm analysis
Continuous cerebrospinal fluid sampling in human subjects
Arterial puncture and catheterization in human subjects
Catecholamine kinetics in arterial and venous blood
Psychometric assessment of mood and anxiety states

Selected Publications

Steinberg Susanne I, Negash Selamawit, Sammel Mary D, Bogner Hillary, Harel Brian T, Livney Melissa G, McCoubrey Hannah, Wolk David A, Kling Mitchel A, Arnold Steven E: Subjective memory complaints, cognitive performance, and psychological factors in healthy older adults. American journal of Alzheimer's disease and other dementias 28(8): 776-83, Dec 2013.

Yarchoan Mark, Louneva Natalia, Xie Sharon X, Swenson Frank J, Hu William, Soares Holly, Trojanowski John Q, Lee Virginia M-Y, Kling Mitchel A, Shaw Leslie M, Chen-Plotkin Alice, Wolk David A, Arnold Steven E: Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease. Journal of the neurological sciences 333(1-2): 9-12, Oct 2013.

Motsinger-Reif, A. A., Zhu, H., Kling, M. A., Matson, W., Sharma, S., Fiehn, O., Reif, D. M., Appleby, D. H., Doraiswamy, P. M., Trojanowski, J. Q., Kaddurah-Daouk, R., Arnold, S. E.: Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer’s disease from normal cognitive aging. Acta Neuropathol Commun 1(1): 28, June 2013.

Kaddurah-Daouk, R., Zhu, H., Sharma, S., Bogdanov, M., Rozen, S. G., Matson, W., Oki, N. O., Motsinger-Reif, A. A., Churchill, E., Lei, Z., Appleby, D., Kling, M. A., Trojanowski, J. Q., Doraiswamy, P. M., Arnold, S. E.: Alterations in metabolic pathways and networks in Alzheimer''s disease. Transl Psychiatry 3: e244, April 2013.

Kling, M. A., Trojanowski, J. Q., Wolk, D. A., Lee, V. M., Arnold, S. E.: Vascular disease and dementias: paradigm shifts to drive research in new directions. Alzheimers Dement 9(1): 76-92, Jan 2013.

Chakravorty, S., Grandner, M. A., Kranzler, H. R., Mavandadi, S., Kling, M. A., Perlis, M. L., Oslin, D. W.: Insomnia in alcohol dependence: predictors of symptoms in a sample of veterans referred from primary care. Am J Addict 22(3): 266-70, 2013.

Yarchoan, M., Xie, S. X., Kling, M. A., Toledo, J. B., Wolk, D. A., Lee, E. B., Van Deerlin, V., Lee, V. M., Trojanowski, J. Q., Arnold, S. E.: Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain 135(Pt 12): 3749-56, 2012.

Gold, P. W., Pavlatou, M. G., Carlson, P. J., Luckenbaugh, D. A., Costello, R., Bonne, O., Csako, G., Drevets, W. C., Remaley, A. T., Charney, D. S., Neumeister, A., Kling, M. A.: Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A. Neurosci Lett 520(1): 1-5, 2012.

Arnold, S.E., Xie, X.S., Leung, Y.-Y., Wang L.-S., Kling, M.A., Han, X., Kim, E.J., Wolk, D.A., Bennett, D.A., Chen-Plotkin, A., Grossman, M., Hu, W., Lee, V.M.-Y., Mackin, R.S., Trojanowski, J.Q., Wilson, R.S., Shaw, L.M., for the Alzheimer's Disease Neuroimaging Initiative: Plasma Biomarkers of Depressive Symptoms in Older Adults. Transl Psychiatry 2: e65, 2012.

Grillon, C., Heller, R., Hirschhorn, E., Kling, M. A., Pine, D. S., Schulkin, J., Vythilingam, M.: Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study. Biol Psychiatry 69(6): 549-55, 2011.

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Last updated: 05/09/2015
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