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Richard C. Crist

Research Assistant Professor of Genetics in Psychiatry
Department: Psychiatry

Contact information
125 South 31st St
Room 2207
Philadelphia, PA 19104
Office: 215-746-3665
BS (Biology)
Muhlenberg College, 2005.
PhD (Genetics)
Thomas Jefferson University, 2011.
Post-Graduate Training
Postdoctoral Fellow, University of Pennsylvania, 2011-2014.
Postdoctoral Researcher in Psychiatry, University of Pennsylvania, 2011-2012.
Postdoctoral Researcher in Psychiatry, University of Pennsylvania, 2013-2014.
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Description of Research Expertise

Genetics; genomics; pharmacogenetics; substance use disorders

Selected Publications

Crist RC, Phillips KA, Furnari MA, Moran LM, Doyle GA, McNicholas LF, Cornish JW, Kampman KM, Preston KL, Berrettini WH: Replication of the pharmacogenetic effect of rs678849 on buprenorphine efficacy in African-Americans with opioid use disorder. The Pharmacogenomics Journal 19(3): 260-268, Jun 2019.

Crist R C, Clarke T K: OPRD1 Genetic Variation and Human Disease. Handbook of Experimental Pharmacology: Delta Opioid Receptor Pharmacology. Emily Jutkiewicz (eds.). Springer, Dec 2016.

Crist RC, Doyle GA, Nelson EC, Degenhardt L, Martin NG, Montgomery GW, Saxon AJ, Ling W, Berrettini WH: A polymorphism in the OPRM1 3'-untranslated region is associated with methadone efficacy in treating opioid dependence. The Pharmacogenomics Journal 18(1): 173-179, Jan 2018 Notes: Epub ahead of print.

Crist R C, Doyle G A, Kampman K M, Berrettini W H: A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. Drug and Alcohol Dependence 166: 268-71, Sep 2016.

Clarke T-K, Crist R C, Ang A, Ambrose-Lanci L M, Lohoff F W, Saxon A J, Ling W, Hillhouse M P, Bruce R D, Woody G, Berrettini W H: Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females. The Pharmacogenomics Journal 14(3): 303-8, Jun 2014.

Crist Richard C, Berrettini Wade H: Pharmacogenetics of OPRM1. Pharmacology, Biochemistry, and Behavior 123: 25-33, Aug 2014.

Crist Richard C, Clarke Toni-Kim, Ang Alfonso, Ambrose-Lanci Lisa M, Lohoff Falk W, Saxon Andrew J, Ling Walter, Hillhouse Maureen P, Bruce R Douglas, Woody George, Berrettini Wade H: An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. Neuropsychopharmacology 38(10): 2003-10, Sep 2013.

Crist Richard C, Ambrose-Lanci Lisa M, Zeng Angela, Yuan Cindy, Kampman Kyle M, Pettinati Helen M, Oslin David W, O'Brien Charles P, Ferraro Thomas N, Doyle Glenn A, Lohoff Falk W, Berrettini Wade H: Case-control association study of WLS variants in opioid and cocaine addicted populations. Psychiatry research 208(1): 62-6, Jun 2013.

Clarke Toni-Kim, Crist Richard C, Kampman Kyle M, Dackis Charles A, Pettinati Helen M, O'Brien Charles P, Oslin David W, Ferraro Thomas N, Lohoff Falk W, Berrettini Wade H: Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine. Neuroscience letters 542: 71-5, May 2013.

Crist R C, Ambrose-Lanci L M, Vaswani M, Clarke T K, Zeng A, Yuan C, Ferraro T N, Hakonarson H, Kampman K M, Dackis C A, Pettinati H M, O'Brien C P, Oslin D W, Doyle G A, Lohoff F W, Berrettini W H: Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations. Drug and alcohol dependence 127(1-3): 122-8, Jan 2013.

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Last updated: 10/28/2021
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