faculty photo

Rachel L. Kember

Assistant Professor of Psychiatry
Department: Psychiatry

Contact information
3535 Market Street
Suite 551
Philadelphia, PA 19104
Office: 215-746-1956
Education:
BSc (Psychology)
University of Leeds, 2006.
MSc (Social, Genetic & Developmental Psychiatry)
Kings College London, 2008.
PhD (Social, Genetic & Developmental Psychiatry)
Kings College London, 2012.
Post-Graduate Training
Postdoctoral Researcher, University of Pennsylvania, 2012-2017.
Permanent link
 
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Selected Publications

Sanchez-Roige, S., Kember, R.L., Agrawal, A.: Substance use and common contributors to morbidity: A genetics perspective. eBioMedicine 83(104212), Sept 2022.

Love T, Shabalin AA, Kember RL, Docherty AR, Zhou H, Koppelmans V, Gelernter J, Baker AK, Hartwell E, Dubroff J, Zubieta JK, Kranzler HR.: Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function. Neuropsychopharmacology 47(10): 1784-1790, Sept 2022.

Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S, Lee KM, Fang H, Chen F, Lu Y, Tsao NL, Raghavan S, Koyama S, Gorman BR, Vujkovic M, Klarin D, Levin MG, Sinnott-Armstrong N, Wojcik GL, Plomondon ME, Maddox TM, Waldo SW, Bick AG, Pyarajan S, Huang J, Song R, Ho YL, Buyske S, Kooperberg C, Haessler J, Loos RJF, Do R, Verbanck M, Chaudhary K, North KE, Avery CL, Graff M, Haiman CA, Le Marchand L, Wilkens LR, Bis JC, Leonard H, Shen B, Lange LA, Giri A, Dikilitas O, Kullo IJ, Stanaway IB, Jarvik GP, Gordon AS, Hebbring S, Namjou B, Kaufman KM, Ito K, Ishigaki K, Kamatani Y, Verma SS, Ritchie MD, Kember RL, Baras A, Lotta LA; Regeneron Genetics Center; CARDIoGRAMplusC4D Consortium; Biobank Japan; Million Veteran Program, Kathiresan S, Hauser ER, Miller DR, Lee JS, Saleheen D, Reaven PD, Cho K, Gaziano JM, Natarajan P, Huffman JE, Voight BF, Rader DJ, Chang KM, Lynch JA, Damrauer SM, Wilson PWF, Tang H, Sun YV, Tsao PS, O'Donnell CJ, Assimes TL.: Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nature Medicine Aug 2022 Notes: doi: 10.1038/s41591-022-01891-3. Online ahead of print.

Toikumo S, Xu H, Gelernter J, Kember RL*, Kranzler HR.*: Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits. Neuropsychopharmacology Aug 2022 Notes: Asterisks indicate shared last authorship. doi: https://doi.org/10.1038/s41386-022-01406-1. Online ahead of print.

Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J.: Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci. Molecular Psychiatry July 2022 Notes: doi: https://doi.org/10.1038/s41380-022-01709-1. Online ahead of print.

Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Townsend Creasy K, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program, Rader DJ, Voight BF, Chang KM.: A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nature Genetics 54(6): 761-771, Jun 2022.

Lee DJ, Hausler R, Le AN, Kelly G, Powers J, Ding J, Feld E, Desai H, Morrison C, Doucette A, Gabriel P, Genetics Center R, Judy RL, Weaver J, Kember R, Damrauer SM, Rader DJ, Domchek SM, Narayan V, Schwartz LE, Maxwell KN.: Association of Inherited Mutations in DNA Repair Genes with Localized Prostate Cancer. European Urology 81(6): 559-67, Jun 2022 Notes: S0302-2838(21)02059-5 [E-Pub ahead of print]

Tcheandjieu C, Xiao K, Tejeda H, Lynch JA, Ruotsalainen S, Bellomo T, Palnati M, Judy R, Klarin D, Kember RL, Verma S; Regeneron Genetics Center; VA Million Veterans Program; FinnGen Project, Palotie A, Daly M, Ritchie M, Rader DJ, Rivas MA, Assimes T, Tsao P, Damrauer S, Priest JR.: High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease. Nature Genetics 54: 772-82, May 2022 Notes: doi: 10.1038/s41588-022-01070-7. Online ahead of print.

Wang L, Desai H, Verma SS, Le A, Hausler R, Verma A, Judy R, Doucette A, Gabriel PE; Regeneron Genetics Center, Nathanson KL, Damrauer SM, Mowery DL, Ritchie MD, Kember RL*, Maxwell KN*.: Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank. Genetics in Medicine 24(3): 601-609, Mar 2022 Notes: Asterisks indicate shared last authorship.

Hartwell EE, Merikangas AK, Verma SS, Ritchie MD; Regeneron Genetics Center, Kranzler HR, Kember RL.: Genetic liability for substance use associated with medical comorbidities in electronic health records of African- and European-ancestry individuals. Addiction Biology 27(1): e13099, Jan 2022.

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Last updated: 08/12/2022
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